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Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) (AA 400-500) antibody

Details for Product No. ABIN966520, Supplier: Login to see
Antigen
  • FLH21957
  • HGK
  • MEKKK4
  • NIK
  • 9430080K19Rik
  • AU043147
  • AU045934
  • AW046177
  • Nik
Epitope
AA 400-500
31
21
15
14
13
10
10
7
7
6
6
6
6
3
2
2
2
1
1
1
1
1
1
1
Reactivity
Human
147
44
25
2
2
2
1
1
1
Host
Mouse
126
29
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
8
8
8
7
7
7
4
1
1
1
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
93
83
36
18
16
14
10
5
4
3
2
1
Supplier
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Immunogen Purified recombinant fragment of MAP4K4 (aa400-500) expressed in E. Coli.
Clone 3C7B5
Isotype IgG1
Purification Ascitic fluid
Alternative Name MAP4K4 (MAP4K4 Antibody Abstract)
Background MAP4K4: mitogen-activated protein kinase kinase kinase kinase 4. The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified.
Synonyms: HGK, NIK
Gene ID 9448
Research Area Signaling
Pathways
Application Notes Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Product cited in: Poinat, De Arcangelis, Sookhareea et al.: "A conserved interaction between beta1 integrin/PAT-3 and Nck-interacting kinase/MIG-15 that mediates commissural axon navigation in C. elegans." in: Current biology : CB, Vol. 12, Issue 8, pp. 622-31, 2002 (PubMed).

Lantinga van Leeuwen, Teske, van Garderen et al.: "Growth hormone gene expression in normal lymph nodes and lymphomas of the dog." in: Anticancer research, Vol. 20, Issue 4, pp. 2371-6, 2000 (PubMed).

Becker, Huynh-Do, Holland et al.: "Nck-interacting Ste20 kinase couples Eph receptors to c-Jun N-terminal kinase and integrin activation." in: Molecular and cellular biology, Vol. 20, Issue 5, pp. 1537-45, 2000 (PubMed).

Background publications Han, Zhu, Ma et al.: "Lowered HGK expression inhibits cell invasion and adhesion in hepatocellular carcinoma cell line HepG2." in: World journal of gastroenterology : WJG, Vol. 16, Issue 36, pp. 4541-8, 2010 (PubMed).

Bouzakri, Zierath: "MAP4K4 gene silencing in human skeletal muscle prevents tumor necrosis factor-alpha-induced insulin resistance." in: The Journal of biological chemistry, Vol. 282, Issue 11, pp. 7783-9, 2007 (PubMed).