MAP4K4 antibody (AA 400-500)

Catalog No. ABIN966520

Product Details anti-MAP4K4 Antibody

Target: MAP4K4 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4))

Binding Specificity: AA 400-500

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MAP4K4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of MAP4K4 (aa400-500) expressed in E. Coli.

Clone: 3C7B5

Isotype: IgG1

Application Details

Application Notes: Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Handling

Format: Liquid

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

References for anti-MAP4K4 antibody (ABIN966520)

Poinat, De Arcangelis, Sookhareea, Zhu, Hedgecock, Labouesse, Georges-Labouesse: "A conserved interaction between beta1 integrin/PAT-3 and Nck-interacting kinase/MIG-15 that mediates commissural axon navigation in C. elegans." in: Current biology : CB, Vol. 12, Issue 8, pp. 622-31, (2002) (PubMed).

Becker, Huynh-Do, Holland, Pawson, Daniel, Skolnik: "Nck-interacting Ste20 kinase couples Eph receptors to c-Jun N-terminal kinase and integrin activation." in: Molecular and cellular biology, Vol. 20, Issue 5, pp. 1537-45, (2000) (PubMed).

Lantinga van Leeuwen, Teske, van Garderen, Mol: "Growth hormone gene expression in normal lymph nodes and lymphomas of the dog." in: Anticancer research, Vol. 20, Issue 4, pp. 2371-6, (2000) (PubMed).

Target Details for MAP4K4

Target: MAP4K4 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4))

Alternative Name: MAP4K4 (MAP4K4 Products)

Synonyms: FLH21957 antibody, HGK antibody, MEKKK4 antibody, NIK antibody, 9430080K19Rik antibody, AU043147 antibody, AU045934 antibody, AW046177 antibody, Nik antibody, mitogen-activated protein kinase kinase kinase kinase 4 antibody, MAP4K4 antibody, Map4k4 antibody

Background: MAP4K4: mitogen-activated protein kinase kinase kinase kinase 4. The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified.
Synonyms: HGK, NIK

Gene ID: 9448