Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) (AA 400-500) antibody

Details for Product No. ABIN966520
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms FLH21957, HGK, MEKKK4, NIK, 9430080K19Rik, AU043147, AU045934, AW046177, Nik
Epitope
AA 400-500
(22), (21), (17), (12), (12), (7), (6), (6), (6), (6), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(137), (61), (41), (37), (36), (1), (1), (1), (1)
Host
Mouse
(116), (28)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(7), (7), (7), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3)
Application
Western Blotting (WB), ELISA
(85), (61), (30), (25), (25), (21), (18), (7), (4), (3), (2), (1), (1)
Pubmed 4 references available
Quantity 0.1 mL
Options
Shipping to United States (Change)
Availability Will be delivered in 5 to 7 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN966520
495.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Purified recombinant fragment of MAP4K4 (aa400-500) expressed in E. Coli.
Clone 3C7B5
Isotype IgG1
Purification Ascitic fluid
Alternative Name MAP4K4
Background MAP4K4: mitogen-activated protein kinase kinase kinase kinase 4. The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified.
Synonyms: HGK, NIK
Gene ID 9448
Research Area Signaling
Application Notes Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Product cited in: Becker, Huynh-Do, Holland et al.: "Nck-interacting Ste20 kinase couples Eph receptors to c-Jun N-terminal kinase and integrin activation." in: Molecular and cellular biology, Vol. 20, Issue 5, pp. 1537-45, 2000 (PubMed).

Lantinga van Leeuwen, Teske, van Garderen et al.: "Growth hormone gene expression in normal lymph nodes and lymphomas of the dog." in: Anticancer research, Vol. 20, Issue 4, pp. 2371-6, 2000 (PubMed).

Poinat, De Arcangelis, Sookhareea et al.: "A conserved interaction between beta1 integrin/PAT-3 and Nck-interacting kinase/MIG-15 that mediates commissural axon navigation in C. elegans." in: Current biology : CB, Vol. 12, Issue 8, pp. 622-31, 2002 (PubMed).

Bouzakri, Zierath: "MAP4K4 gene silencing in human skeletal muscle prevents tumor necrosis factor-alpha-induced insulin resistance." in: The Journal of biological chemistry, Vol. 282, Issue 11, pp. 7783-9, 2007 (PubMed).

Validation Images
Did you look for something else?
back to top