MAP4K4 Products
(Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4))
Categories
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
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Featured MAP4K4 Categories
MAP4K4 Antibodies
High quality antibodies with extensive validation data.
MAP4K4 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended MAP4K4 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p)
Validations
- (2)
- (4)
Cat. No.
ABIN564078
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, IHC
Validations
- (4)
Cat. No.
ABIN7160070
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IF, ICC
Validations
- (3)
Cat. No.
ABIN6258275
Quantity
100 μL
Datasheet
Datasheet
Recommended MAP4K4 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1310250
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
Cat. No.
ABIN3093709
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
Cat. No.
ABIN5508956
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our MAP4K4 products
: "MAP4K4 promotes epithelial-mesenchymal transition and metastasis in hepatocellular carcinoma." in: Tumour biology, Vol. 37, Issue 8, pp. 11457-67, (2016) (PubMed).: "Intracellular Theileria annulata promote invasive cell motility through kinase regulation of the host actin cytoskeleton." in: PLoS pathogens, Vol. 10, Issue 3, pp. e1004003, (2014) (PubMed).
: "Evaluation of protein biomarkers of prostate cancer aggressiveness." in: BMC cancer, Vol. 14, pp. 244, (2014) (PubMed).
: "Filopodia and membrane blebs drive efficient matrix invasion of macrophages transformed by the intracellular parasite Theileria annulata." in: PLoS ONE, Vol. 8, Issue 9, pp. e75577, (2013) (PubMed).
: "Identification of a novel role of Septin 10 in paclitaxel-resistance in cancers through a functional genomics screen." in: Cancer science, Vol. 103, Issue 4, pp. 821-7, (2012) (PubMed).
: "Tribological considerations in primary and revision metal-on-metal arthroplasty." in: The Journal of bone and joint surgery. American volume, Vol. 90 Suppl 3, pp. 118-24, (2008) (PubMed).
: "MAP4K4 gene silencing in human skeletal muscle prevents tumor necrosis factor-alpha-induced insulin resistance." in: The Journal of biological chemistry, Vol. 282, Issue 11, pp. 7783-9, (2007) (PubMed).
: "The STE20 kinase HGK is broadly expressed in human tumor cells and can modulate cellular transformation, invasion, and adhesion." in: Molecular and cellular biology, Vol. 23, Issue 6, pp. 2068-82, (2003) (PubMed).
: "A conserved interaction between beta1 integrin/PAT-3 and Nck-interacting kinase/MIG-15 that mediates commissural axon navigation in C. elegans." in: Current biology : CB, Vol. 12, Issue 8, pp. 622-31, (2002) (PubMed).
: "Nck-interacting Ste20 kinase couples Eph receptors to c-Jun N-terminal kinase and integrin activation." in: Molecular and cellular biology, Vol. 20, Issue 5, pp. 1537-45, (2000) (PubMed).
Synonyms and alternative names related to MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4), mitogen-activated protein kinase kinase kinase kinase 4 (Map4k4), 9430080K19Rik, AU043147, AU045934, AW046177, FLH21957, HGK, MEKKK4, NIK, NikProtein level used designations for MAP4K4
- HPK/GCK-like kinase HGK
- MAPK/ERK kinase kinase kinase 4
- MEK kinase kinase 4
- Ste20 group protein kinase HGK
- hepatocyte progenitor kinase-like/germinal center kinase-like kinase
- nck-interacting kinase
- MEKKK 4
- NCK interacting kinase
- mitogen activated protein kinase kinase kinase kinase 4
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