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Chemokine (C-C Motif) Ligand 2 (CCL2) (N-Term) antibody

Details for Product No. ABIN966546, Supplier: Log in to see
Antigen
  • MCP-1
  • Scya2
  • Sigje
  • GDCF-2
  • HC11
  • HSMCR30
  • MCAF
  • MCP1
  • SCYA2
  • SMC-CF
  • AI323594
  • JE
  • MCP-1A
  • MCP1A
  • chemokine (C-C motif) ligand 2
  • macrophage cationic peptide 1
  • mast cell proteinase-1
  • CCL2
  • Ccl2
  • MCP-1
  • MCP1
Alternatives
anti-Human Chemokine (C-C Motif) Ligand 2 antibody for Enzyme Immunoassay
Epitope
N-Term
25
24
21
18
18
11
11
10
10
7
7
6
6
5
4
3
2
2
2
1
1
1
Reactivity
Human
391
133
109
19
14
14
11
10
6
6
6
5
4
4
1
1
Host
Rabbit
287
200
23
14
8
8
6
Clonality
Polyclonal
Conjugate
Un-conjugated
67
38
26
11
7
7
7
6
6
5
5
5
5
4
3
3
3
3
3
2
2
2
Application
Western Blotting (WB)
428
327
135
76
64
57
53
51
36
35
31
22
13
6
5
5
5
4
4
2
2
2
2
1
1
1
1
Options
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Immunogen A synthetic peptide corresponding to a sequence at the N-terminal of human MCP-1, different from the mouse and rat sequence by two amino acids< br/>Immunogen was affinity purified.
Isotype IgG
Cross-Reactivity Mouse (Murine), Rat (Rattus)
Cross-Reactivity (Details) No cross reactivity with other proteins.
Characteristics Rabbit IgG polyclonal antibody for C-C motif chemokine 2 ( CCL2) detection. Tested with WB in Human, Mouse, Rat.
Alternative Name C-C motif chemokine 2 (CCL2 Antibody Abstract)
Background Monocyte chemoattractant protein-1 (MCP-1), a member of the chemokine (chemotactic cytokine) family, is a potent monocyte agonist that is upregulated by oxidized lipids. 1 MCP-1 is also known as CCL2, SCYA2, MCAF. MCAF is a member of family of factors involved in immune and inflammatory responses. The amino acid sequence deduced from the nucleotide sequence reveals the primary structure of the MCAF precursor to be composed of a putative signal peptide sequence of 23 amino acid residues and a mature MCAF sequence of 76 amino acid residues. 2 MCP-1 plays a unique and crucial role in the initiation of atherosclerosis and may provide a new therapeutic target in this disorder. 3 Human MCP-1 is a 8. 7KDa non-glycoprotein, consisting of 99 amino acids in precursor form and 76 amino acids in mature form.
Pathways Cellular Response to Molecule of Bacterial Origin
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Buffer Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
Preservative Sodium azide, Thimerosal (Merthiolate)
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.
Product cited in: Gosling, Slaymaker, Gu, Tseng, Zlot, Young, Rollins, Charo: "MCP-1 deficiency reduces susceptibility to atherosclerosis in mice that overexpress human apolipoprotein B." in: The Journal of clinical investigation, Vol. 103, Issue 6, pp. 773-8, 1999 (PubMed).

Gu, Okada, Clinton, Gerard, Sukhova, Libby, Rollins: "Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice." in: Molecular cell, Vol. 2, Issue 2, pp. 275-81, 1998 (PubMed).

Furutani, Nomura, Notake, Oyamada, Fukui, Yamada, Larsen, Oppenheim, Matsushima: "Cloning and sequencing of the cDNA for human monocyte chemotactic and activating factor (MCAF)." in: Biochemical and biophysical research communications, Vol. 159, Issue 1, pp. 249-55, 1989 (PubMed).