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Myosin, Light Chain 2, Regulatory, Cardiac, Slow (MYL2) antibody

Details for Product No. ABIN966625, Supplier: Log in to see
Antigen
  • 2410014J02Rik
  • MLC-2
  • Mlc2
  • CMH10
  • MLC2
  • Mlc-2
  • myosin
  • regulatory
  • MLC-2v
  • Mlc2v
  • Mylpc
Reactivity
Human
64
19
18
3
1
1
1
Host
Mouse
37
32
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
1
1
Application
ELISA, Western Blotting (WB)
58
39
17
14
8
5
2
2
1
1
Supplier
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Immunogen Purified recombinant fragment of MYL2 expressed in E. Coli.
Clone 7C9
Isotype IgG1
Purification Ascitic fluid
Alternative Name MYL2 (MYL2 Antibody Abstract)
Background MYL2(myosin, light chain 2, regulatory, cardiac, slow), also known as MLC-2, MLC2v. Entrez protein NP_000423. MYL2 associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. It is an hexamer of two heavy chains and four light chains that is predominantly expressed in adult cardiac ventricle muscle. Mutations in MYL2 are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy.
Synonyms: MLC2, CMH10, DKFZp779C0562
Molecular Weight 19kDa
Gene ID 4633
Pathways
Application Notes Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Product cited in: Sachdev, Raychowdhury, Sarkar: "Human fast skeletal myosin light chain 2 cDNA: isolation, tissue specific expression of the single copy gene, comparative sequence analysis of isoforms and evolutionary relationships." in: DNA sequence : the journal of DNA sequencing and mapping, Vol. 14, Issue 5, pp. 339-50, 2004 (PubMed).

Background publications Ueda, Murata-Hori, Tatsuka et al.: "Rho-kinase contributes to diphosphorylation of myosin II regulatory light chain in nonmuscle cells." in: Oncogene, Vol. 21, Issue 38, pp. 5852-60, 2002 (PubMed).