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Details for Product No. ABIN966625

Myosin, Light Chain 2, Regulatory, Cardiac, Slow (MYL2) antibody

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Antigen
Synonyms Mlc2, MLC-2, 2410014J02Rik, MLC-2v, Mlc2v, Mylpc, CMH10, MLC2, myosin, regulatory, Mlc-2
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Application
»Alternatives Western Blotting (WB), ELISA
Pubmed 2 references available
Catalog no. ABIN966625
Quantity 0.1 mL
Price
371.25 $   Plus shipping costs $45.00
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Product details

Target Details Application Details Handling References Alternatives back to top
Immunogen Purified recombinant fragment of MYL2 expressed in E. Coli.
Clone 7C9
Isotype IgG1
Purification Ascitic fluid

Target Details

Application Details Handling References Alternatives back to top
Alternative Name MYL2
Background MYL2(myosin, light chain 2, regulatory, cardiac, slow), also known as MLC-2, MLC2v. Entrez protein NP_000423. MYL2 associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. It is an hexamer of two heavy chains and four light chains that is predominantly expressed in adult cardiac ventricle muscle. Mutations in MYL2 are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy.
Synonyms: MLC2, CMH10, DKFZp779C0562
Molecular Weight 19kDa
Gene ID 4633

Application Details

Target Details Handling References Alternatives back to top
Application Notes Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only

Handling

Target Details Application Details References Alternatives back to top
Preservative Sodium azide
Storage 4 °C

References

Target Details Application Details Handling Alternatives back to top
Product cited in: Ueda, Murata-Hori, Tatsuka et al.: "Rho-kinase contributes to diphosphorylation of myosin II regulatory light chain in nonmuscle cells." in: Oncogene, Vol. 21, Issue 38, pp. 5852-60, 2002 (PubMed).

Sachdev, Raychowdhury, Sarkar: "Human fast skeletal myosin light chain 2 cDNA: isolation, tissue specific expression of the single copy gene, comparative sequence analysis of isoforms and evolutionary relationships." in: DNA sequence : the journal of DNA sequencing and mapping, Vol. 14, Issue 5, pp. 339-50, 2004 (PubMed).

Alternatives

Target Details Application Details Handling References back to top
Alternatives for antigen "Myosin, Light Chain 2, Regulatory, Cardiac, Slow (MYL2)", type "Antibodies"
Hosts (20), (13)
Reactivities (35), (9), (7), (2), (2), (2), (1), (1)
Applications (29), (22), (10), (4), (3), (2), (2), (2), (1)
Epitopes (7), (4), (2), (2)
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