MYL2 antibody (AA 8-164)

Catalog No. ABIN7160551

Product Details anti-MYL2 Antibody

Target: MYL2 (Myosin, Light Chain 2, Regulatory, Cardiac, Slow (MYL2))

Binding Specificity: AA 8-164

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MYL2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Myosin regulatory light chain 2, ventricular/cardiac muscle isoform protein (8-164AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for MYL2

Target: MYL2 (Myosin, Light Chain 2, Regulatory, Cardiac, Slow (MYL2))

Alternative Name: MYL2 (MYL2 Products)

Synonyms: CMH10 antibody, MLC2 antibody, 2410014J02Rik antibody, MLC-2 antibody, Mlc2 antibody, MLC-2v antibody, Mlc2v antibody, Mylpc antibody, Mlc-2 antibody, myl2 antibody, zgc:136848 antibody, XMLC2 antibody, cmh10 antibody, mlc2 antibody, G2 antibody, MLC-2A antibody, MLC2V antibody, myosin light chain 2 antibody, myosin light chain, phosphorylatable, fast skeletal muscle antibody, myosin, light polypeptide 2, regulatory, cardiac, slow antibody, myosin, light chain 2b, regulatory, cardiac, slow antibody, myosin light chain 2 S homeolog antibody, myosin, light chain 2, regulatory, cardiac, slow antibody, MYL2 antibody, Mylpf antibody, Myl2 antibody, myl2b antibody, myl2.S antibody

Background:

Background: Contractile protein that plays a role in heart development and function. Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion, as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force. During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly.

Aliases: Cardiac myosin light chain-2 antibody, Cardiac ventricular myosin light chain 2 antibody, CMH10 antibody, MLC 2v antibody, MLC-2 antibody, MLC-2v antibody, MLC2 antibody, MLRV_HUMAN antibody, MYL 2 antibody, MYL2 antibody, Myosin light chain 2 regulatory cardiac slow antibody, Myosin light polypeptide 2 regulatory cardiac slow antibody, Myosin regulatory light chain 2 antibody, Myosin regulatory light chain 2 ventricular/cardiac muscle isoform antibody, Regulatory light chain of myosin antibody, RLC of myosin antibody, Slow cardiac myosin regulatory light chain 2 antibody, ventricular/cardiac muscle isoform antibody

UniProt: P10916

Pathways: Myometrial Relaxation and Contraction