Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 2 (NFKB2) (Middle Region) antibody

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Antigen
Synonyms NF-kappaB2, lyt, p49, p49/p100, p50B, p52, H2TF1, LYT-10, LYT10, NF-kB2, p105, RGD1307189, p100, wu:fa03b02, zgc:136693
Epitope
Middle Region
(15), (15), (12), (9), (7), (5), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(83), (26), (20), (3), (2), (1), (1)
Host
Rabbit
(85), (6)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC)
(76), (28), (25), (18), (17), (14), (10), (4), (3), (2), (1), (1)
Pubmed 7 references available
Quantity 0.1 mg
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Catalog No. ABIN966670
466.13 $
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to middle amino acid residues of human NFKB2 (Nuclear factor NF-kappa-B p100 subunit)
Alternative Name NFKB2
Background NFKB2 (Nuclear factor NF-kappa-B p100 subunit) is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappaB sites that they can bind with distinguishable affinity and specificity. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function.
Synonyms: LYT10(Lymphocyte translocation chromosome 10)
Restrictions For Research Use only
Product cited in: Bours, Burd, Brown et al.: "A novel mitogen-inducible gene product related to p50/p105-NF-kappa B participates in transactivation through a kappa B site." in: Molecular and cellular biology, Vol. 12, Issue 2, pp. 685-95, 1992 (PubMed).

Schmid, Perkins, Duckett et al.: "Cloning of an NF-kappa B subunit which stimulates HIV transcription in synergy with p65." in: Nature, Vol. 352, Issue 6337, pp. 733-6, 1991 (PubMed).

Dobrzanski, Ryseck, Bravo: "Differential interactions of Rel-NF-kappa B complexes with I kappa B alpha determine pools of constitutive and inducible NF-kappa B activity." in: The EMBO journal, Vol. 13, Issue 19, pp. 4608-16, 1994 (PubMed).

Beg, Baldwin: "Activation of multiple NF-kappa B/Rel DNA-binding complexes by tumor necrosis factor." in: Oncogene, Vol. 9, Issue 5, pp. 1487-92, 1994 (PubMed).

Potter, Larson, Eckes et al.: "Purification of the major histocompatibility complex class I transcription factor H2TF1. The full-length product of the nfkb2 gene." in: The Journal of biological chemistry, Vol. 268, Issue 25, pp. 18882-90, 1993 (PubMed).

Bours, Franzoso, Azarenko et al.: "The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers." in: Cell, Vol. 72, Issue 5, pp. 729-39, 1993 (PubMed).

Li, Nabel: "A new member of the I kappaB protein family, I kappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription." in: Molecular and cellular biology, Vol. 17, Issue 10, pp. 6184-90, 1997 (PubMed).

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