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NFKB2 antibody (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 2 (p49/p100)) (Middle Region)

Details for Product anti-NFKB2 Antibody No. ABIN966670, Supplier: Login to see New
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Synonyms NF-kappaB2, lyt, p49, p49/p100, p50B, p52
Middle Region
(18), (17), (15), (13), (9), (6), (5), (5), (5), (4), (4), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
(131), (58), (36), (2), (2), (2), (1), (1)
(135), (10)
This NFKB2 antibody is un-conjugated
(6), (4), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (IHC)
(113), (44), (36), (30), (28), (23), (11), (10), (4), (4), (3), (1), (1), (1), (1)
Pubmed 7 references available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 5 to 7 Business Days
Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to middle amino acid residues of human NFKB2 (Nuclear factor NF-kappa-B p100 subunit)
Alternative Name NFKB2 (NFKB2 Antibody Abstract)
Background NFKB2 (Nuclear factor NF-kappa-B p100 subunit) is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappaB sites that they can bind with distinguishable affinity and specificity. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function.
Synonyms: LYT10(Lymphocyte translocation chromosome 10)
Restrictions For Research Use only
Product cited in: Li, Nabel: "A new member of the I kappaB protein family, I kappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription." in: Molecular and cellular biology, Vol. 17, Issue 10, pp. 6184-90, 1997 (PubMed).

Bours, Franzoso, Azarenko et al.: "The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers." in: Cell, Vol. 72, Issue 5, pp. 729-39, 1993 (PubMed).

Potter, Larson, Eckes et al.: "Purification of the major histocompatibility complex class I transcription factor H2TF1. The full-length product of the nfkb2 gene." in: The Journal of biological chemistry, Vol. 268, Issue 25, pp. 18882-90, 1993 (PubMed).

Beg, Baldwin: "Activation of multiple NF-kappa B/Rel DNA-binding complexes by tumor necrosis factor." in: Oncogene, Vol. 9, Issue 5, pp. 1487-92, 1994 (PubMed).

Dobrzanski, Ryseck, Bravo: "Differential interactions of Rel-NF-kappa B complexes with I kappa B alpha determine pools of constitutive and inducible NF-kappa B activity." in: The EMBO journal, Vol. 13, Issue 19, pp. 4608-16, 1994 (PubMed).

Schmid, Perkins, Duckett et al.: "Cloning of an NF-kappa B subunit which stimulates HIV transcription in synergy with p65." in: Nature, Vol. 352, Issue 6337, pp. 733-6, 1991 (PubMed).

Bours, Burd, Brown et al.: "A novel mitogen-inducible gene product related to p50/p105-NF-kappa B participates in transactivation through a kappa B site." in: Molecular and cellular biology, Vol. 12, Issue 2, pp. 685-95, 1992 (PubMed).

Catalog No. ABIN966670
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