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Opioid Receptor, mu 1 (OPRM1) (C-Term) antibody
|Synonyms||MOR, LMOR, MOR1, OPRM, KIAA0403, mor, Oprm, muOR, MOP-R, MOR-1, MOR-1O, MORA, Oprrm1, or2, ZFOR2, OPRM1, M-OR-1|
Human, Mouse (Murine)
Alternatives Immunohistochemistry (IHC)
|7 references available|
|Price||452.38 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 5 to 7 Business Days|
|Immunogen||Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to very Cterminal residues of human OPRM1(Mu-type opioid receptor)|
|Description||OPRM1(Mu-type opioid receptor) inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. OPRM1forms a complex with G(alpha)z/i2 subunits and the RGSZ proteins, RGSZ17 and RGSZ20. The formation of this complex results in mu-opioid receptor desensitization. OPRM1 interacts with RGSZ17 and RGSZ20. OPRM1 is a multi-pass membrane protein. The polymorphism Variant Asp-40 does not show altered binding affinities for most opioid peptides and alkaloids tested, but it binds beta-endorphin, an endogenous opioid that activates the mu opioid receptor, approximately 3 times more tightly than the most common allelic form. OPRM1(Mu-type opioid receptor) belongs to the G-protein coupled receptor 1 family.|
|Research Area||Hormones, Receptors, Neurology|
|Restrictions||For Research Use only|
Mestek, Hurley, Bye et al.: "The human mu opioid receptor: modulation of functional desensitization by calcium/calmodulin-dependent protein kinase and protein kinase C." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 15, Issue 3 Pt 2, pp. 2396-406, 1995 (PubMed).
Wang, Johnson, Persico et al.: "Human mu opiate receptor. cDNA and genomic clones, pharmacologic characterization and chromosomal assignment." in: FEBS letters, Vol. 338, Issue 2, pp. 217-22, 1994 (PubMed).
Bare, Mansson, Yang: "Expression of two variants of the human mu opioid receptor mRNA in SK-N-SH cells and human brain." in: FEBS letters, Vol. 354, Issue 2, pp. 213-6, 1994 (PubMed).
Uhl, Sora, Wang: "The mu opiate receptor as a candidate gene for pain: polymorphisms, variations in expression, nociception, and opiate responses." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 14, pp. 7752-5, 1999 (PubMed).
Pan, Xu, Mahurter et al.: "Identification and characterization of two new human mu opioid receptor splice variants, hMOR-1O and hMOR-1X." in: Biochemical and biophysical research communications, Vol. 301, Issue 4, pp. 1057-61, 2003 (PubMed).
Pan, Xu, Yu et al.: "Identification and characterization of six new alternatively spliced variants of the human mu opioid receptor gene, Oprm." in: Neuroscience, Vol. 133, Issue 1, pp. 209-20, 2005 (PubMed).
Xu, Xu, Hurd et al.: "Isolation and characterization of new exon 11-associated N-terminal splice variants of the human mu opioid receptor gene." in: Journal of neurochemistry, Vol. 108, Issue 4, pp. 962-72, 2009 (PubMed).