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Mu Opioid Receptor 1 antibody (Opioid Receptor, mu 1) (C-Term)

Details for Product anti-OPRM1 Antibody No. ABIN966719, Supplier: Login to see New
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Synonyms or2, ZFOR2, OPRM1, Mor1, MORA, Oprm, Oprrm1, LMOR, M-OR-1, MOP, MOR, MOR1, OPRM, MOP-R, MOR-1, MOR-1O, mor, muOR, 6430411K18Rik, Mar, Mart1, Peg11
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(25), (16), (15), (13), (11), (10), (9), (5), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Human, Mouse (Murine)
(101), (44), (41), (6), (5), (5), (3), (1), (1), (1), (1), (1), (1), (1)
(102), (4), (3)
This Mu Opioid Receptor 1 antibody is un-conjugated
(3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (IHC)
(74), (43), (34), (20), (16), (13), (9), (8), (2), (2), (1)
Pubmed 7 references available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 5 to 7 Business Days
Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to very Cterminal residues of human OPRM1(Mu-type opioid receptor)
Alternative Name OPRM1 (OPRM1 Antibody Abstract)
Background OPRM1(Mu-type opioid receptor) inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. OPRM1forms a complex with G(alpha)z/i2 subunits and the RGSZ proteins, RGSZ17 and RGSZ20. The formation of this complex results in mu-opioid receptor desensitization. OPRM1 interacts with RGSZ17 and RGSZ20. OPRM1 is a multi-pass membrane protein. The polymorphism Variant Asp-40 does not show altered binding affinities for most opioid peptides and alkaloids tested, but it binds beta-endorphin, an endogenous opioid that activates the mu opioid receptor, approximately 3 times more tightly than the most common allelic form. OPRM1(Mu-type opioid receptor) belongs to the G-protein coupled receptor 1 family.
Research Area Hormones, Receptors, Neurology
Pathways TCR Signaling
Restrictions For Research Use only
Product cited in: Xu, Xu, Hurd et al.: "Isolation and characterization of new exon 11-associated N-terminal splice variants of the human mu opioid receptor gene." in: Journal of neurochemistry, Vol. 108, Issue 4, pp. 962-72, 2009 (PubMed).

Pan, Xu, Yu et al.: "Identification and characterization of six new alternatively spliced variants of the human mu opioid receptor gene, Oprm." in: Neuroscience, Vol. 133, Issue 1, pp. 209-20, 2005 (PubMed).

Pan, Xu, Mahurter et al.: "Identification and characterization of two new human mu opioid receptor splice variants, hMOR-1O and hMOR-1X." in: Biochemical and biophysical research communications, Vol. 301, Issue 4, pp. 1057-61, 2003 (PubMed).

Uhl, Sora, Wang: "The mu opiate receptor as a candidate gene for pain: polymorphisms, variations in expression, nociception, and opiate responses." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 14, pp. 7752-5, 1999 (PubMed).

Bare, Mansson, Yang: "Expression of two variants of the human mu opioid receptor mRNA in SK-N-SH cells and human brain." in: FEBS letters, Vol. 354, Issue 2, pp. 213-6, 1994 (PubMed).

Wang, Johnson, Persico et al.: "Human mu opiate receptor. cDNA and genomic clones, pharmacologic characterization and chromosomal assignment." in: FEBS letters, Vol. 338, Issue 2, pp. 217-22, 1994 (PubMed).

Mestek, Hurley, Bye et al.: "The human mu opioid receptor: modulation of functional desensitization by calcium/calmodulin-dependent protein kinase and protein kinase C." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 15, Issue 3 Pt 2, pp. 2396-406, 1995 (PubMed).

Catalog No. ABIN966719
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