Opioid Receptor, mu 1 (OPRM1) (C-Term) antibody

Details for Product No. ABIN966719
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Antigen
Synonyms or2, ZFOR2, OPRM1, Mor1, MORA, Oprm, Oprrm1, LMOR, M-OR-1, MOP, MOR, MOR1, OPRM, MOP-R, MOR-1, MOR-1O, mor, muOR, 6430411K18Rik, Mar, Mart1, Peg11
Epitope
C-Term
(18), (11), (8), (7), (7), (4), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(86), (40), (37), (24), (24), (24), (13)
Host
Rabbit
(91), (2), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application
Immunohistochemistry (IHC)
(62), (37), (30), (20), (20), (12), (9), (6), (4), (2)
Pubmed 7 references available
Quantity 0.1 mg
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Catalog No. ABIN966719
452.38 $
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to very Cterminal residues of human OPRM1(Mu-type opioid receptor)
Alternative Name OPRM1
Background OPRM1(Mu-type opioid receptor) inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. OPRM1forms a complex with G(alpha)z/i2 subunits and the RGSZ proteins, RGSZ17 and RGSZ20. The formation of this complex results in mu-opioid receptor desensitization. OPRM1 interacts with RGSZ17 and RGSZ20. OPRM1 is a multi-pass membrane protein. The polymorphism Variant Asp-40 does not show altered binding affinities for most opioid peptides and alkaloids tested, but it binds beta-endorphin, an endogenous opioid that activates the mu opioid receptor, approximately 3 times more tightly than the most common allelic form. OPRM1(Mu-type opioid receptor) belongs to the G-protein coupled receptor 1 family.
Research Area Hormones, Receptors, Neurology
Restrictions For Research Use only
Product cited in: Mestek, Hurley, Bye et al.: "The human mu opioid receptor: modulation of functional desensitization by calcium/calmodulin-dependent protein kinase and protein kinase C." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 15, Issue 3 Pt 2, pp. 2396-406, 1995 (PubMed).

Wang, Johnson, Persico et al.: "Human mu opiate receptor. cDNA and genomic clones, pharmacologic characterization and chromosomal assignment." in: FEBS letters, Vol. 338, Issue 2, pp. 217-22, 1994 (PubMed).

Bare, Mansson, Yang: "Expression of two variants of the human mu opioid receptor mRNA in SK-N-SH cells and human brain." in: FEBS letters, Vol. 354, Issue 2, pp. 213-6, 1994 (PubMed).

Uhl, Sora, Wang: "The mu opiate receptor as a candidate gene for pain: polymorphisms, variations in expression, nociception, and opiate responses." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 14, pp. 7752-5, 1999 (PubMed).

Pan, Xu, Mahurter et al.: "Identification and characterization of two new human mu opioid receptor splice variants, hMOR-1O and hMOR-1X." in: Biochemical and biophysical research communications, Vol. 301, Issue 4, pp. 1057-61, 2003 (PubMed).

Pan, Xu, Yu et al.: "Identification and characterization of six new alternatively spliced variants of the human mu opioid receptor gene, Oprm." in: Neuroscience, Vol. 133, Issue 1, pp. 209-20, 2005 (PubMed).

Xu, Xu, Hurd et al.: "Isolation and characterization of new exon 11-associated N-terminal splice variants of the human mu opioid receptor gene." in: Journal of neurochemistry, Vol. 108, Issue 4, pp. 962-72, 2009 (PubMed).

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