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Details for Product No. ABIN966724

P-Cadherin (AA 612-626) antibody

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Antigen
Synonyms
CDHP, HJMD, PCAD, AI385538, Cadp, Cdhp, P-cadherin, Pcad, E-Cad, E-cadherin, EP-cadherin, XTCAD-1, c-cadherin, cadherin-1, cdh1, cdh1-b, cdh3, cdhc-A, cdhp, hjmd, l-cam, lcam, pcad, uvo, uvomorulin, x ... show more
Epitope
»Alternatives AA 612-626
Reactivity
»Alternatives Human
Host
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)
Pubmed 1 reference available
Catalog no. ABIN966724
Quantity 100 µg
Price
316.25 $   Plus shipping costs $45.00
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Availability Will be delivered in 5 to 7 Business Days
Immunogen A synthetic peptide corresponding to a sequence at the middle region of human P-Cadherin (612-626 aa), different from the mouse and rat sequence by one amino acid.
Background Cadherins, such as CDH3, are integral membrane glycoproteins responsible for calcium-dependent cell-cell adhesion. Cadherin-3 is a protein that in humans is encoded by the CDH3 gene. This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy.
Application Notes WB: The detection limit for P-Cadherin is approximately 2.5ng/lane under non-reducing and reducing conditions.
Restrictions For Research Use only
Reconstitution 0.2ml of distilled water will yield a concentration of 500µg/ml.
Buffer Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4
Preservative Thimerosal (Merthiolate), Sodium azide
Storage -20 °C
Product cited in: Kaupmann, Becker-Follmann, Scherer et al.: "The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species." in: Genomics, Vol. 14, Issue 2, pp. 488-90, 1992 (PubMed).

Alternatives for antigen "P-Cadherin", type "Antibodies"
Hosts (51), (18), (1), (1)
Reactivities (68), (26), (22), (18), (17), (17), (17), (1), (1)
Applications (45), (21), (20), (19), (17), (10), (7), (5), (4), (4), (3)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (7), (6), (4), (4), (3), (3), (2), (2), (1)
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