P-Cadherin antibody (AA 24-350)

Catalog No. ABIN7269142

This Rabbit Polyclonal antibody specifically detects P-Cadherin in WB, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for P-Cadherin antibody (AA 24-350) (ABIN7269142)

Target: P-Cadherin (CDH3)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This P-Cadherin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-P-Cadherin Antibody

Binding Specificity: AA 24-350

Purpose: CDH3 Rabbit pAb

Sequence: SEPCRAVFRE AEVTLEAGGA EQEPGQALGK VFMGCPGQEP ALFSTDNDDF TVRNGETVQE RRSLKERNPL KIFPSKRILR RHKRDWVVAP ISVPENGKGP FPQRLNQLKS NKDRDTKIFY SITGPGADSP PEGVFAVEKE TGWLLLNKPL DREEIAKYEL FGHAVSENGA SVEDPMNISI IVTDQNDHKP KFTQDTFRGS VLEGVLPGTS VMQVTATDED DAIYTYNGVV AYSIHSQEPK DPHDLMFTIH RSTGTISVIS SGLDREKVPE YTLTIQATDM DGDGSTTTAV AVVEILDAND NAPMFDPQKY EAHVPENAVG HEVQRLT

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 24-350 of human CDH3 (NP_001784.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for P-Cadherin

Target: P-Cadherin (CDH3)

Alternative Name: CDH3

Background: This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene are associated with hypotrichosis with juvenile macular dystrophy and ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome (EEMS).,CDH3,CDHP,HJMD,PCAD,Signal Transduction,Cell Biology & Developmental Biology,Cell Adhesion,Cadherins,Tight Junctions,Cytoskeleton,Wnt/β-Catenin Signaling Pathway,Neuroscience,CDH3

Molecular Weight: 86kDa/91kDa

Gene ID: 1001

UniProt: P22223