Docking Protein 1, 62kDa (Downstream of tyrosine Kinase 1) (DOK1) antibody

Details for Product No. ABIN966767
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Antigen
Synonyms 4432404K01Rik, ARTC4, DO, DOK1, AW557123, p62DOK, Dok-1, P62DOK
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(205), (115), (115), (36), (36), (36)
Host
Rabbit
(204), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(6), (6), (6), (4), (4), (4), (4), (4), (4), (4), (4), (1), (1), (1)
Application
Immunohistochemistry (IHC)
(161), (70), (49), (45), (40), (15), (14), (10), (10), (4), (2), (1), (1)
Pubmed 4 references available
Quantity 100 μg
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Catalog No. ABIN966767
398.75 $
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Immunogen The antiserum was produced against synthesized non-phosphopeptide derived from human p62Dok around the phosphorylation site of tyrosine 398 (E-G-YP-E-L).
Specificity P62Dok (Ab-398) antibody detects endogenous levels of total p62Dok protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Alternative Name p62Dok
Application Notes WB: 1:500~1:1000
IHC: 1:50~1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Wick, Dong, Hu et al.: "Insulin receptor-mediated p62dok tyrosine phosphorylation at residues 362 and 398 plays distinct roles for binding GTPase-activating protein and Nck and is essential for inhibiting insulin-stimulated activation of Ras and Akt." in: The Journal of biological chemistry, Vol. 276, Issue 46, pp. 42843-50, 2001 (PubMed).

Dubé, Cheng, Tremblay: "The role of protein tyrosine phosphatase 1B in Ras signaling." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 7, pp. 1834-9, 2004 (PubMed).

Yopp, Ochando, Mao et al.: "Sphingosine 1-phosphate receptors regulate chemokine-driven transendothelial migration of lymph node but not splenic T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 175, Issue 5, pp. 2913-24, 2005 (PubMed).

Simoncic, Bourdeau, Lee-Loy et al.: "T-cell protein tyrosine phosphatase (Tcptp) is a negative regulator of colony-stimulating factor 1 signaling and macrophage differentiation." in: Molecular and cellular biology, Vol. 26, Issue 11, pp. 4149-60, 2006 (PubMed).

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