Polymerase (RNA) Mitochondrial (DNA Directed) (POLRMT) (C-Term) antibody

Antigen: Polymerase (RNA) Mitochondrial (DNA Directed) (POLRMT)

Synonyms: APOLMT, MTRNAP, MTRPOL, h-mtRPOL, MGC118526, 4932416K13, 1110018N15Rik, polrmt-a, mtRPO, wu:fb73g10, si:dkeyp-74c5.5, POLRMT

Binding Site: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Immunohistochemistry (IHC)

Catalog no.: ABIN966880

Additional Information

Alternative name: POLRMT

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human POLRMT(DNA-directed RNA polymerase, mitochondrial)

Description: POLRMT(DNA-directed RNA polymerase, mitochondrial) is responsible for mitochondrial gene expression as well as for providing RNA primers for initiation of replication of the mitochondrial genome. Although this polypeptide has the same function as the three nuclear DNAdirected RNA polymerases, it is more closely related to RNA polymerases of phage and mitochondrial polymerases of lower eukaryotes. POLRMT(DNA-directed RNA polymerase, mitochondrial) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. POLRMT interacts with TFB1M and TFB2M, leading to the stimulation of family.

Application Details

Restrictions: For Research Use only

Publications

Product: Tiranti, Savoia, Forti et al.: "Identification of the gene encoding the human mitochondrial RNA polymerase (h-mtRPOL) by cyberscreening of the Expressed Sequence Tags database." in: Human molecular genetics, Vol. 6, Issue 4, pp. 615-25, 1997 (PubMed).

Gaspari, Falkenberg, Larsson et al.: "The mitochondrial RNA polymerase contributes critically to promoter specificity in mammalian cells." in: The EMBO journal, Vol. 23, Issue 23, pp. 4606-14, 2004 (PubMed).

Kravchenko, Rogozin, Koonin et al.: "Transcription of mammalian messenger RNAs by a nuclear RNA polymerase of mitochondrial origin." in: Nature, Vol. 436, Issue 7051, pp. 735-9, 2005 (PubMed).

Wang, Cotney, Shadel: "Human mitochondrial ribosomal protein MRPL12 interacts directly with mitochondrial RNA polymerase to modulate mitochondrial gene expression." in: The Journal of biological chemistry, Vol. 282, Issue 17, pp. 12610-8, 2007 (PubMed).

Bogenhagen, Rousseau, Burke: "The layered structure of human mitochondrial DNA nucleoids." in: The Journal of biological chemistry, Vol. 283, Issue 6, pp. 3665-75, 2008 (PubMed).