RANK (CD265) (N-Term), (AA 29-44) antibody

Details for Product No. ABIN966946
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Antigen
Synonyms Ly109, ODFR, OFE, Rank, TRANCE-R, mRANK, CD265, FEO, LOH18CR1, OPTB7, OSTS, PDB2, RANK, TRANCER, RGD1563614
Epitope
N-Term, AA 29-44
(4), (3), (2), (2), (2), (1), (1), (1)
Reactivity
Human
(55), (47), (24), (12), (12)
Host
Please enquire
(46), (20), (9), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(11), (11), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Application
Western Blotting (WB)
(40), (28), (20), (13), (12), (10), (5), (1), (1)
Pubmed 3 references available
Quantity 100 µg
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Catalog No. ABIN966946
316.25 $
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Immunogen A synthetic peptide corresponding to a sequence at the N-terminal of human RANK (29-44 aa), identical to the related mouse and rat sequence.
Alternative Name RANK
Background Receptor Activator of Nuclear Factor B (RANK), also known as TRANCE Receptor, is a type I membrane protein that is expressed on the surface of osteoclasts and is involved in their activation upon ligand binding. RANK is also expressed on dendritic cells and facilitates immune signaling.RANKL (Receptor Activator for Nuclear Factor B Ligand) is found on the surface of stromal cells, osteoblasts, and T cells. By analysis of somatic cell and radiation hybrid panels, Anderson et al. (1997) mapped the RANK gene to 18q22.1.
Research Area Cardiovascular, Atherosclerosis, Extracellular Matrix, Innate Immunity, Cytokines
Application Notes WB: The detection limit for RANK is approximately 2.5ng/lane under non-reducing and reducing conditions.
Restrictions For Research Use only
Reconstitution 0.2ml of distilled water will yield a concentration of 500µg/ml.
Buffer Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4
Preservative Thimerosal (Merthiolate), Sodium azide
Storage -20 °C
Product cited in: Suda, Takahashi, Udagawa et al.: "Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families." in: Endocrine reviews, Vol. 20, Issue 3, pp. 345-57, 1999 (PubMed).

Wong, Josien, Choi: "TRANCE is a TNF family member that regulates dendritic cell and osteoclast function." in: Journal of leukocyte biology, Vol. 65, Issue 6, pp. 715-24, 1999 (PubMed).

Theill, Boyle, Penninger: "RANK-L and RANK: T cells, bone loss, and mammalian evolution." in: Annual review of immunology, Vol. 20, pp. 795-823, 2002 (PubMed).

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