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SMAD1 antibody (C-Term)

SMAD1 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN967044
  • Target See all SMAD1 Antibodies
    SMAD1 (SMAD, Mothers Against DPP Homolog 1 (SMAD1))
    Binding Specificity
    • 24
    • 24
    • 24
    • 15
    • 9
    • 8
    • 8
    • 8
    • 6
    • 6
    • 6
    • 5
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 193
    • 117
    • 88
    • 8
    • 8
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 1
    Human
    Host
    • 193
    • 17
    Rabbit
    Clonality
    • 186
    • 25
    Polyclonal
    Conjugate
    • 99
    • 17
    • 12
    • 7
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    This SMAD1 antibody is un-conjugated
    Application
    • 166
    • 82
    • 53
    • 52
    • 44
    • 28
    • 20
    • 17
    • 14
    • 12
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Cross-Reactivity
    Mouse (Murine), Rat (Rattus)
    Cross-Reactivity (Details)
    No cross reactivity with other proteins.
    Characteristics
    Rabbit IgG polyclonal antibody for Mothers against decapentaplegic homolog 1 (SMAD1) detection. Tested with WB in Human, Mouse, Rat.
    Immunogen
    A synthetic peptide corresponding to a sequence at the C-terminal of human Smad 1,2,3,5, identical to the related mouse and rat sequences.< br/>Immunogen was affinity purified.
    Isotype
    IgG
    Top Product
    Discover our top product SMAD1 Primary Antibody
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    Preservative
    Sodium azide, Thimerosal (Merthiolate)
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    -20 °C
    Storage Comment
    At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.
  • Zhu, Kavsak, Abdollah, Wrana, Thomsen: "A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation." in: Nature, Vol. 400, Issue 6745, pp. 687-93, (1999) (PubMed).

  • Target
    SMAD1 (SMAD, Mothers Against DPP Homolog 1 (SMAD1))
    Alternative Name
    Mothers against decapentaplegic homolog 1(MAD homolog 1/Mothers against DPP homolog 1) (SMAD1 Products)
    Background
    SMADs are proteins that modulate the activity of transforming growth factor beta ligands. The SMADs, often in complex with other SMADs/CoSMAD, act as transcription factors that regulate the expression of certain genes. Zhu, H et al concluded that targeted ubiquitination of SMADs may serve to control both embryonic development and a wide variety of cellular responses to TGF-beta signals. R-Smads or receptor regulated Smads are a class of proteins that include SMAD1, SMAD2, SMAD3, SMAD5, and SMAD8. In response to signals by the TGF-beta superfamily of ligands these proteins associate with receptor kinases and are phosphorylated at an SSXS motif at their extreme C-terminus. These proteins then typically bind to the common mediator Smad or co-SMAD SMAD4.
    Pathways
    Stem Cell Maintenance, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
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