SMAD, Mothers Against DPP Homolog 1 (SMAD1) (C-Term) antibody

Details for Product No. ABIN967044, Supplier: Log in to see
Antigen
  • MLP
  • Xmad1
  • Xsmad1
  • bsp1
  • jv4-1
  • jv41
  • madh1
  • madr1
  • smad-1
  • MADH1
  • fb39h09
  • wu:fb39h09
  • wu:fb97e04
  • 2/23
  • CG12399
  • Dmel\\CG12399
  • E(zen)2
  • En(vvl)
  • MAD
  • Mat
  • P-Mad
  • P-mad
  • PMad
  • Smad
  • Smad1
  • apg
  • c28
  • dMAD
  • dMad
  • l(2)K00237
  • l(2)k00237
  • mad
  • p-Mad
  • pMAD
  • pMad
  • pSmad
  • BSP-1
  • BSP1
  • JV4-1
  • JV41
  • MADR1
  • AI528653
  • Madh1
  • Madr1
  • Mlp1
  • MusMLP
  • smad1
  • xmad
  • SMAD family member 1
  • MAD homolog 1 (Drosophila)
  • Mothers against dpp
  • smad1
  • SMAD1
  • Mad
  • Smad1
  • smad1-a
Alternatives
anti-Human SMAD, Mothers Against DPP Homolog 1 antibody for Cellular Assay
Epitope
C-Term
46
32
19
19
18
15
13
8
8
7
6
5
5
4
4
4
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
304
204
182
16
16
13
12
11
9
9
8
7
7
6
6
3
2
2
2
2
2
2
2
2
1
1
Host
Rabbit
280
45
2
Clonality
Polyclonal
Conjugate
Un-conjugated
11
9
6
3
3
3
3
3
3
3
3
3
3
3
2
2
2
Application
Western Blotting (WB)
283
125
68
48
39
38
19
16
7
6
5
4
2
2
1
1
1
1
1
Options
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Immunogen A synthetic peptide corresponding to a sequence at the C-terminal of human Smad 1,2,3,5, identical to the related mouse and rat sequences.< br/>Immunogen was affinity purified.
Isotype IgG
Cross-Reactivity Mouse (Murine), Rat (Rattus)
Cross-Reactivity (Details) No cross reactivity with other proteins.
Characteristics Rabbit IgG polyclonal antibody for Mothers against decapentaplegic homolog 1 (SMAD1) detection. Tested with WB in Human, Mouse, Rat.
Alternative Name Mothers against decapentaplegic homolog 1(MAD homolog 1/Mothers against DPP homolog 1) (SMAD1 Antibody Abstract)
Background SMADs are proteins that modulate the activity of transforming growth factor beta ligands. The SMADs, often in complex with other SMADs/CoSMAD, act as transcription factors that regulate the expression of certain genes. Zhu, H et al concluded that targeted ubiquitination of SMADs may serve to control both embryonic development and a wide variety of cellular responses to TGF-beta signals. R-Smads or receptor regulated Smads are a class of proteins that include SMAD1, SMAD2, SMAD3, SMAD5, and SMAD8. In response to signals by the TGF-beta superfamily of ligands these proteins associate with receptor kinases and are phosphorylated at an SSXS motif at their extreme C-terminus. These proteins then typically bind to the common mediator Smad or co-SMAD SMAD4.
Pathways Stem Cell Maintenance, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Buffer Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
Preservative Sodium azide, Thimerosal (Merthiolate)
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.
Product cited in: Zhu, Kavsak, Abdollah, Wrana, Thomsen: "A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation." in: Nature, Vol. 400, Issue 6745, pp. 687-93, 1999 (PubMed).