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SOCS2 antibody (Suppressor of Cytokine Signaling 2) (C-Term)

Details for Product anti-SOCS2 Antibody No. ABIN967065, Supplier: Login to see
Antigen
  • si:dkey-202b22.1
  • socs2
  • cis2
  • ssi2
  • cish2
  • ssi-2
  • socs-2
  • stati2
  • CIS2
  • Cish2
  • SOCS-2
  • SSI-2
  • SSI2
  • STATI2
  • 8030460M17
  • AI527257
  • AW108012
  • D130043N08Rik
  • JAB
  • hg
  • Socs-2
Alternatives
anti-Human SOCS2 antibody for ELISA
Epitope
C-Term, AA 181-198
14
5
4
4
3
2
2
1
1
1
1
1
1
1
Reactivity
Human, Rat (Rattus)
52
16
15
2
2
2
2
Host
49
5
2
Clonality
Polyclonal
Conjugate
This SOCS2 antibody is un-conjugated
1
1
1
Application
Western Blotting (WB)
36
16
12
10
8
2
2
1
1
1
Supplier
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Immunogen A synthetic peptide corresponding to a sequence at the C-terminal of human SOCS2 (181-198 aa), identical to the related mouse and rat sequence.
Alternative Name SOCS2 (SOCS2 Antibody Abstract)
Background Suppressor of cytokine signaling 2 is a protein that in humans is encoded by the SOCS2 gene. This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signalling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon-gamma (IFN-gamma). The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor 1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling. Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control. By cytogenetic and radiation hybrid mapping, Yandava et al. (1999) mapped the SOCS2 gene to chromosome 12q21.3-q23.
Research Area Signaling, Innate Immunity, Cytokines
Pathways JAK-STAT Signaling
Restrictions For Research Use only
Reconstitution 0.2ml of distilled water will yield a concentration of 500µg/ml.
Buffer Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4
Preservative Thimerosal (Merthiolate), Sodium azide
Storage -20 °C
Product cited in: Greenhalgh, Bertolino, Asa et al.: "Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b)." in: Molecular endocrinology (Baltimore, Md.), Vol. 16, Issue 6, pp. 1394-406, 2002 (PubMed).

Dey, Spence, Nissley et al.: "Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor." in: The Journal of biological chemistry, Vol. 273, Issue 37, pp. 24095-101, 1998 (PubMed).

Masuhara, Sakamoto, Matsumoto et al.: "Cloning and characterization of novel CIS family genes." in: Biochemical and biophysical research communications, Vol. 239, Issue 2, pp. 439-46, 1997 (PubMed).

Minamoto, Ikegame, Ueno et al.: "Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3." in: Biochemical and biophysical research communications, Vol. 237, Issue 1, pp. 79-83, 1997 (PubMed).