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Details for Product No. ABIN967065

Suppressor of Cytokine Signaling 2 (SOCS2) (C-Term), (AA 181-198) antibody

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Synonyms CIS2, SSI2, Cish2, SSI-2, SOCS-2, STATI2, Socs-2, 8030460M17, AI527257, AW108012, D130043N08Rik, JAB, hg, SOCS2, si:dkey-202b22.1, socs2, cis2, ssi2, cish2, ssi-2, socs-2, stati2
»Alternatives C-Term, AA 181-198
»Alternatives Human, Rat (Rattus)
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN967065
Quantity 100 µg
316.25 $   Plus shipping costs $45.00
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Availability Will be delivered in 5 to 7 Business Days
Immunogen A synthetic peptide corresponding to a sequence at the C-terminal of human SOCS2 (181-198 aa), identical to the related mouse and rat sequence.
Alternative Name SOCS2
Background Suppressor of cytokine signaling 2 is a protein that in humans is encoded by the SOCS2 gene. This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signalling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon-gamma (IFN-gamma). The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor 1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling. Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control. By cytogenetic and radiation hybrid mapping, Yandava et al. (1999) mapped the SOCS2 gene to chromosome 12q21.3-q23.
Research Area Signaling, Innate Immunity, Cytokines
Restrictions For Research Use only
Reconstitution 0.2ml of distilled water will yield a concentration of 500µg/ml.
Buffer Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4
Preservative Thimerosal (Merthiolate), Sodium azide
Storage -20 °C
Product cited in: Minamoto, Ikegame, Ueno et al.: "Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3." in: Biochemical and biophysical research communications, Vol. 237, Issue 1, pp. 79-83, 1997 (PubMed).

Masuhara, Sakamoto, Matsumoto et al.: "Cloning and characterization of novel CIS family genes." in: Biochemical and biophysical research communications, Vol. 239, Issue 2, pp. 439-46, 1997 (PubMed).

Dey, Spence, Nissley et al.: "Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor." in: The Journal of biological chemistry, Vol. 273, Issue 37, pp. 24095-101, 1998 (PubMed).

Greenhalgh, Bertolino, Asa et al.: "Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b)." in: Molecular endocrinology (Baltimore, Md.), Vol. 16, Issue 6, pp. 1394-406, 2002 (PubMed).

Alternatives for antigen "Suppressor of Cytokine Signaling 2 (SOCS2)", type "Antibodies"
Hosts (43), (4), (3)
Reactivities (49), (22), (20), (13), (12), (12)
Applications (26), (15), (15), (10), (10), (2), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (11), (4), (3), (3), (1)