Suppressor of Cytokine Signaling 2 (SOCS2) (C-Term), (AA 181-198) antibody

Details for Product No. ABIN967065
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Antigen
Synonyms si:dkey-202b22.1, socs2, cis2, ssi2, cish2, ssi-2, socs-2, stati2, CIS2, Cish2, SOCS-2, SSI-2, SSI2, STATI2, 8030460M17, AI527257, AW108012, D130043N08Rik, JAB, hg, Socs-2
Epitope
C-Term, AA 181-198
(12), (6), (3), (3), (1), (1), (1), (1), (1)
Reactivity
Human, Rat (Rattus)
(50), (22), (22), (12), (12), (12)
Host
(48), (3), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(28), (14), (14), (10), (10), (3), (1)
Pubmed 4 references available
Quantity 100 µg
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Catalog No. ABIN967065
316.25 $
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Immunogen A synthetic peptide corresponding to a sequence at the C-terminal of human SOCS2 (181-198 aa), identical to the related mouse and rat sequence.
Alternative Name SOCS2
Background Suppressor of cytokine signaling 2 is a protein that in humans is encoded by the SOCS2 gene. This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signalling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon-gamma (IFN-gamma). The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor 1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling. Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control. By cytogenetic and radiation hybrid mapping, Yandava et al. (1999) mapped the SOCS2 gene to chromosome 12q21.3-q23.
Research Area Signaling, Innate Immunity, Cytokines
Restrictions For Research Use only
Reconstitution 0.2ml of distilled water will yield a concentration of 500µg/ml.
Buffer Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4
Preservative Thimerosal (Merthiolate), Sodium azide
Storage -20 °C
Product cited in: Minamoto, Ikegame, Ueno et al.: "Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3." in: Biochemical and biophysical research communications, Vol. 237, Issue 1, pp. 79-83, 1997 (PubMed).

Masuhara, Sakamoto, Matsumoto et al.: "Cloning and characterization of novel CIS family genes." in: Biochemical and biophysical research communications, Vol. 239, Issue 2, pp. 439-46, 1997 (PubMed).

Dey, Spence, Nissley et al.: "Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor." in: The Journal of biological chemistry, Vol. 273, Issue 37, pp. 24095-101, 1998 (PubMed).

Greenhalgh, Bertolino, Asa et al.: "Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b)." in: Molecular endocrinology (Baltimore, Md.), Vol. 16, Issue 6, pp. 1394-406, 2002 (PubMed).

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