Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1) antibody

Details for Product No. ABIN967214
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Antigen
Synonyms ASPCR1, ASPL, ASPS, RCC17, TUG, UBXD9, UBXN9, ASPC, 1190006K01Rik, tug, aspl, asps, rcc17, ubxd9, aspcr1
Reactivity
Mouse (Murine)
(15), (9), (3)
Host
Please enquire
(16), (12)
Clonality
Monoclonal
Application
Western Blotting (WB), ELISA
(25), (13), (2), (1), (1)
Pubmed 1 reference available
Catalog no. ABIN967214
Quantity 0.1 mg
Price
371.25 $   Plus shipping costs $45.00
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Isotype IgG1
Specificity Ni-NTA purified truncated recombinant TUG expressed in E. Coli strain BL21 (DE3)
Purification Antibodies are purified by protein A affinity chromatography
Alternative Name TUG
Background The TUG protein contains a UBX domain, for GLUT4. In truncated form, TUG acts in a dominantnegative manner to inhibit insulin-stimulated GLUT4 redistribution in Chinese hamster ovary cells and 3T3-L1 adipocytes. Full-length TUG forms a complex specifically with GLUT4. In 3T3-L1 adipocytes, this complex is present in unstimulated cells and is largely disassembled by insulin. Endogenous TUG is localized with the insulin-mobilizable pool of GLUT4 in unstimulated 3T3-L1 adipocytes, and is not mobilized to the plasma membrane by insulin.
Gene ID 68938
Research Area Signaling, Metabolism
Application Notes Western Blot: 1: 500- 1: 2,000
ELISA: Propose dilution 1: 10,000.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Buffer PBS with 0.2%BSA
Preservative Sodium azide
Storage -20 °C
Product cited in: Bogan, Hendon, McKee et al.: "Functional cloning of TUG as a regulator of GLUT4 glucose transporter trafficking." in: Nature, Vol. 425, Issue 6959, pp. 727-33, 2003 (PubMed).

Hosts (16), (12)
Reactivities (15), (9), (3)
Applications (25), (13), (2), (1), (1)
Epitopes (3), (2), (2), (2), (1), (1), (1), (1)
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