Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1) antibody

Details for Product No. ABIN967214
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Antigen
Synonyms tug, aspl, asps, rcc17, ubxd9, aspcr1, ASPCR1, ASPL, ASPS, RCC17, TUG, UBXD9, UBXN9, 1190006K01Rik, ASPC
Reactivity
Mouse (Murine)
(38), (12), (2)
Host
(32), (19)
Clonality
Monoclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB), ELISA
(47), (28), (3), (3), (2), (2), (2), (2)
Pubmed 1 reference available
Quantity 0.1 mg
Options
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Catalog No. ABIN967214
385.00 $
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Isotype IgG1
Specificity Ni-NTA purified truncated recombinant TUG expressed in E. Coli strain BL21 (DE3)
Purification Antibodies are purified by protein A affinity chromatography
Alternative Name TUG
Background The TUG protein contains a UBX domain, for GLUT4. In truncated form, TUG acts in a dominantnegative manner to inhibit insulin-stimulated GLUT4 redistribution in Chinese hamster ovary cells and 3T3-L1 adipocytes. Full-length TUG forms a complex specifically with GLUT4. In 3T3-L1 adipocytes, this complex is present in unstimulated cells and is largely disassembled by insulin. Endogenous TUG is localized with the insulin-mobilizable pool of GLUT4 in unstimulated 3T3-L1 adipocytes, and is not mobilized to the plasma membrane by insulin.
Gene ID 68938
Research Area Signaling, Metabolism
Application Notes Western Blot: 1: 500- 1: 2,000
ELISA: Propose dilution 1: 10,000.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Buffer PBS with 0.2%BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Bogan, Hendon, McKee et al.: "Functional cloning of TUG as a regulator of GLUT4 glucose transporter trafficking." in: Nature, Vol. 425, Issue 6959, pp. 727-33, 2003 (PubMed).

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