WW Domain Containing Oxidoreductase (WWOX) (N-Term) antibody

Antigen: WW Domain Containing Oxidoreductase (WWOX)

Synonyms: FOR, WOX1, FRA16D, HHCMA56, PRO0128, SDR41C1, D16S432E, 5330426P09Rik, 9030416C10Rik, MGC55975, zgc:55975, GB11795, WWOX, DKFZp469M0323

Binding Site: N-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse (Murine)

Conjugate: Un-conjugated

Application: Immunohistochemistry (IHC)

Catalog no.: ABIN967262

Additional Information

Alternative name: WWOX

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human WWOX (WW domain-containing oxidoreductase)

Description: WWOX (WW domain-containing oxidoreductase) is a probable oxidoreductase, which acts as a tumor suppressor and plays a role in apoptosis. WWOX may function synergistically with TP53/p53 to control genotoxic stress-induced cell death. WWOX may also play a role in tumor necrosis factor (TNF)-mediated cell death.WWOX interacts with TP53, TP73/p73 and MAPK8. WWOX forms a ternary complex with TP53 and MDM2. WWOX is widely expressed and strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Defects in WWOX may be involved in several cancer types. Defects in WWOX may be involved in esophageal squamous cell carcinoma (ESCC)
Synonyms: FOR, WOX1

Application Details

Research Area: Chromatin and Nuclear Signaling, Transcription Factors, Alzheimer's Disease, Apoptosis/Necrosis

Restrictions: For Research Use only

Publications

Product: Bednarek, Laflin, Daniel et al.: "WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer." in: Cancer research, Vol. 60, Issue 8, pp. 2140-5, 2000 (PubMed).

Ried, Finnis, Hobson et al.: "Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells." in: Human molecular genetics, Vol. 9, Issue 11, pp. 1651-63, 2000 (PubMed).

Paige, Taylor, Taylor et al.: "WWOX: a candidate tumor suppressor gene involved in multiple tumor types." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 20, pp. 11417-22, 2001 (PubMed).

Bednarek, Keck-Waggoner, Daniel et al.: "WWOX, the FRA16D gene, behaves as a suppressor of tumor growth." in: Cancer research, Vol. 61, Issue 22, pp. 8068-73, 2001 (PubMed).

Chang, Doherty, Ensign: "JNK1 physically interacts with WW domain-containing oxidoreductase (WOX1) and inhibits WOX1-mediated apoptosis." in: The Journal of biological chemistry, Vol. 278, Issue 11, pp. 9195-202, 2003 (PubMed).

Park, Ludes-Meyers, Zimonjic et al.: "Frequent downregulation and loss of WWOX gene expression in human hepatocellular carcinoma." in: British journal of cancer, Vol. 91, Issue 4, pp. 753-9, 2004 (PubMed).

Aqeilan, Palamarchuk, Weigel et al.: "Physical and functional interactions between the Wwox tumor suppressor protein and the AP-2gamma transcription factor." in: Cancer research, Vol. 64, Issue 22, pp. 8256-61, 2004 (PubMed).