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WWOX antibody (AA 1-245)

WWOX Reactivity: Human, Mouse, Rat WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN5693294
  • Target See all WWOX Antibodies
    WWOX (WW Domain Containing Oxidoreductase (WWOX))
    Binding Specificity
    • 12
    • 12
    • 9
    • 7
    • 6
    • 6
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-245
    Reactivity
    • 56
    • 47
    • 11
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 65
    • 3
    • 2
    Rabbit
    Clonality
    • 69
    • 1
    Polyclonal
    Conjugate
    • 42
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This WWOX antibody is un-conjugated
    Application
    • 49
    • 30
    • 12
    • 10
    • 7
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Brand
    Picoband™
    Cross-Reactivity (Details)
    No cross reactivity with other proteins.
    Characteristics
    Rabbit IgG polyclonal antibody for WWOX detection. Tested with WB, IHC-P, Direct ELISA in Human,Mouse,Rat.
    Immunogen
    E. coli-derived human WWOX recombinant protein (Position: M1-D245).
    Top Product
    Discover our top product WWOX Primary Antibody
  • Application Notes

    Recommended Detection Systems: Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).

    Application Details: Western blot, 0.1-0.5 μg/mL
    Immunohistochemistry(Paraffin-embedded Section), 0.5-1 μg/mL
    Direct ELISA, 0.1-0.5 μg/mL

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Buffer
    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
  • Target
    WWOX (WW Domain Containing Oxidoreductase (WWOX))
    Alternative Name
    WWOX (WWOX Products)
    Synonyms
    CG7221 antibody, DmWWOX antibody, Dmel\\CG7221 antibody, anon-EST:Posey177 antibody, GB11795 antibody, WWOX antibody, D16S432E antibody, FOR antibody, FRA16D antibody, HHCMA56 antibody, PRO0128 antibody, SDR41C1 antibody, WOX1 antibody, zgc:55975 antibody, 5330426P09Rik antibody, 9030416C10Rik antibody, WW domain containing oxidoreductase antibody, WW domain-containing oxidoreductase antibody, Wwox antibody, LOC411815 antibody, WWOX antibody, CpipJ_CPIJ004939 antibody, MCYG_01584 antibody, VDBG_05631 antibody, VDBG_01326 antibody, VDBG_06753 antibody, Tsp_03967 antibody, LOC100284583 antibody, wwox antibody
    Background

    Synonyms: WW domain-containing oxidoreductase, Fragile site FRA16D oxidoreductase, Short chain dehydrogenase/reductase family 41C member 1, WWOX, FOR, SDR41C1, WOX1

    Tissue Specificity: Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines.

    Background: WW domain-containing oxidoreductase is an enzyme that in humans is encoded by the WWOX gene. This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. It spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants.

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