Solute Carrier Family 39 (Zinc Transporter), Member 4 (SLC39A4) (C-Term) antibody

Details for Product No. ABIN967274
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Antigen
Synonyms AEZ, AWMS2, ZIP4, 1600025H15Rik, AU041686
Epitope
C-Term
(9), (5), (5), (2), (1), (1), (1)
Reactivity
Human
(35), (9), (3), (1)
Host
Rabbit
(32), (3), (1)
Clonality
Polyclonal
Application
Immunohistochemistry (IHC)
(33), (21), (8), (3), (1)
Pubmed 3 references available
Quantity 0.1 mg
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Catalog No. ABIN967274
452.38 $
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human ZIP4 (Zinc transporter ZIP4)
Alternative Name ZIP4
Background ZIP4 (Zinc transporter ZIP4) plays an important role in cellular zinc homeostasis as a zinc transporter. ZIP4 is regulated in response to zinc availability. ZIP4 is a multi-pass membrane protein and is colocalized with TFRC in the recycling endosomes. ZIP4 cycles between endosomal compartments and the plasma membrane in response to zinc availability. ZIP4 is highly expressed in kidney, small intestine, stomach, colon, jejunum and duodenum. Defects in SLC39A4 are the cause of acrodermatitis enteropathica zinc-deficiency type (AEZ). AEZ is a rare autosomal recessive disease caused by the inability to absorb sufficient zinc. The clinicals features are growth retardation, immune system dysfunction, alopecia, severe dermatitis, diarrhea and occasionally mental disorders. All these manifestations are reversible with zinc supplementation. Without zinc therapy this disease is fatal. ZIP4 belongs to the ZIP transporter (TC 2.A.5) family.
Synonyms: SLC39A4 (Solute carrier family 39 member 4), ZIP-4 (Zrt- and Irt-like protein 4)
Restrictions For Research Use only
Product cited in: Wang, Zhou, Kuo et al.: "A novel member of a zinc transporter family is defective in acrodermatitis enteropathica." in: American journal of human genetics, Vol. 71, Issue 1, pp. 66-73, 2002 (PubMed).

Küry, Dréno, Bézieau et al.: "Identification of SLC39A4, a gene involved in acrodermatitis enteropathica." in: Nature genetics, Vol. 31, Issue 3, pp. 239-40, 2002 (PubMed).

Kim, Wang, Dufner-Beattie et al.: "Zn2+-stimulated endocytosis of the mZIP4 zinc transporter regulates its location at the plasma membrane." in: The Journal of biological chemistry, Vol. 279, Issue 6, pp. 4523-30, 2004 (PubMed).

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