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Sialophorin (SPN) antibody

Details for Product No. ABIN967347
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Antigen
Synonyms CD43, GALGP, GPL115, LSN, Cd43, Lsn, Lsn1, gpL115, A630014B01Rik, Galgp, Ly-48, Ly48
Reactivity
Human
(231), (57), (51), (17), (3), (2), (2)
Host
Mouse
(204), (79), (32)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(42), (37), (36), (11), (6), (5), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Flow Cytometry (FACS), Functional Studies (Func), Immunoprecipitation (IP), Western Blotting (WB), Immunohistochemistry (IHC)
(221), (108), (107), (50), (44), (39), (38), (17), (15), (14), (5), (4), (2), (1), (1)
Pubmed 9 references available
Quantity 0.1 mg
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Catalog No. ABIN967347
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  • +1 404 474 4654
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Clone L60
Isotype IgG1, kappa
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name CD43 (Leukosialin)
Background Anti-leukosialin monoclonal antibody (clone L60) recognizes a sialic acid-dependent determinant on leukosialin, a strongly anionic, highly o-linked glycosylated cell surface protein with a 45 nm extracellular domain. Leukosialin, also know as sialophorin or CD43, is a major component of T lymphocyte, thymocyte, and neutrophil (PMN) membranes, and is also expressed on many different cells including monocytes, platelets, bone marrow stem cells, and plasma cells.
Research Area CD Antigens
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/ml
Buffer Aqueous buffered solution.
Preservative Without preservative
Storage 4 °C
Supplier Images
anti-Sialophorin (SPN) antibody Profile of CD43 (L60) reactivity on peripheral blood lymphocytes analyzed by flow cytometry. Second step staining.
Product cited in: Kuijpers, Hoogerwerf, Kuijpers et al.: "Cross-linking of sialophorin (CD43) induces neutrophil aggregation in a CD18-dependent and a CD18-independent way." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 149, Issue 3, pp. 998-1003, 1992 (PubMed).

Rieu, Porteu, Bessou et al.: "Human neutrophils release their major membrane sialoprotein, leukosialin (CD43), during cell activation." in: European journal of immunology, Vol. 22, Issue 11, pp. 3021-6, 1992 (PubMed).

Cyster, Williams: "The importance of cross-linking in the homotypic aggregation of lymphocytes induced by anti-leukosialin (CD43) antibodies." in: European journal of immunology, Vol. 22, Issue 10, pp. 2565-72, 1992 (PubMed).

Ardman, Sikorski, Staunton: "CD43 interferes with T-lymphocyte adhesion." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 11, pp. 5001-5, 1992 (PubMed).

Segal, Stoler, Tubbs: "The "CD43 only" phenotype. An aberrant, nonspecific immunophenotype requiring comprehensive analysis for lineage resolution." in: American journal of clinical pathology, Vol. 97, Issue 6, pp. 861-5, 1992 (PubMed).

Rosenstein, Park, Hahn et al.: "CD43, a molecule defective in Wiskott-Aldrich syndrome, binds ICAM-1." in: Nature, Vol. 354, Issue 6350, pp. 233-5, 1992 (PubMed).

Campanero, Pulido, Alonso et al.: "Down-regulation by tumor necrosis factor-alpha of neutrophil cell surface expression of the sialophorin CD43 and the hyaluronate receptor CD44 through a proteolytic mechanism." in: European journal of immunology, Vol. 21, Issue 12, pp. 3045-8, 1992 (PubMed).

Park, Rosenstein, Remold-ODonnell et al.: "Enhancement of T-cell activation by the CD43 molecule whose expression is defective in Wiskott-Aldrich syndrome." in: Nature, Vol. 350, Issue 6320, pp. 706-9, 1991 (PubMed).

Bazil, Strominger: "CD43, the major sialoglycoprotein of human leukocytes, is proteolytically cleaved from the surface of stimulated lymphocytes and granulocytes." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 9, pp. 3792-6, 1993 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN967347
Contact our Customer Service for availability and price in your country.
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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