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V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN) (AA 1-138) antibody

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Synonyms LYN, lyn, JTK8, p53Lyn, p56Lyn, AA407514, Hck-2
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AA 1-138
(45), (18), (16), (13), (9), (9), (8), (7), (6), (5), (5), (5), (4), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Chicken, Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
(183), (86), (63), (15), (10), (4), (4), (1), (1), (1)
(145), (38), (17), (3)
Clonality (Clone)
Monoclonal ()
(9), (7), (6), (5), (5), (5), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
(174), (87), (65), (30), (20), (18), (14), (14), (7), (5), (3), (1)
Pubmed 5 references available
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Quantity 50 μg
Shipping to United States ( )
Immunogen Human Lyn aa. 1-138
Clone 42-Lyn
Isotype IgG1
Cross-Reactivity Dog (Canine), Rat (Rattus), Mouse (Murine)
No Cross-Reactivity Chicken
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name Lyn (LYN Antibody Abstract)
Background Lyn is a 56 kDa cytosolic tyrosine kinase that belongs to the Src family of kinases. In addition to Src, this family includes lck, Fgr, Hck, Blk, Yes, fyn, and Yrk kinases. The lyn gene was isolated from a human placenta cDNA library and later found in a variety of cell types. Similar to other members of the Src family of tyrosine kinases, Lyn has been implicated in the regulation of cell signaling mechanisms. Lyn's function has primarily been studied in hematopoietic cells where it is associated with the high-affinity IgE receptor in basophils. It also associates with p120 Ras-GAP in thrombin-stimulated platelets. This association corresponds to an increase in Lyn kinase activity. Lyn is often observed as a doublet of about 56 kDa and 53 kDa. These forms may represent alternative splicing products of lyn mRNA.
Molecular Weight 56 kDa
Research Area Signaling, Tyrosine Kinases
Pathways Fc-epsilon Receptor Signaling Pathway

Related Products: ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20° C.
Supplier Images
Western Blotting (WB) image for anti-V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN) (AA 1-138) antibody (ABIN967688) Western blot analysis of Lyn on HEL (human erythroleukemia cell line) lysate. Lane 1:...
Immunofluorescence (IF) image for anti-V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN) (AA 1-138) antibody (ABIN967688) Immunofluorescent staining on Human Fibroblasts
Product cited in: Liang, Wisniewski, Strife et al.: "Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling." in: The Journal of biological chemistry, Vol. 277, Issue 16, pp. 13732-8, 2002 (PubMed).

Müller, Jung, Wied et al.: "Redistribution of glycolipid raft domain components induces insulin-mimetic signaling in rat adipocytes." in: Molecular and cellular biology, Vol. 21, Issue 14, pp. 4553-67, 2001 (PubMed).

Deehan, Harnett, Harnett: "A filarial nematode-secreted phosphorylcholine-containing glycoprotein uncouples the B cell antigen receptor from extracellular signal-regulated kinase-mitogen-activated protein kinase by promoting the surface Ig-mediated recruitment of Src homology 2 dom" in: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 12, pp. 7462-8, 2001 (PubMed).

Liu, Oh, Horner et al.: "Organized endothelial cell surface signal transduction in caveolae distinct from glycosylphosphatidylinositol-anchored protein microdomains." in: The Journal of biological chemistry, Vol. 272, Issue 11, pp. 7211-22, 1997 (PubMed).

Bolen, Rowley, Spana et al.: "The Src family of tyrosine protein kinases in hemopoietic signal transduction." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 6, Issue 15, pp. 3403-9, 1993 (PubMed).

Catalog No. ABIN967688
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