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beta Catenin antibody (Catenin, beta) (AA 571-781)

Details for Product anti-Catenin, beta Antibody No. ABIN967784, Supplier: Login to see
Antigen
  • Bfc
  • Catnb
  • Mesc
  • ctnnb
  • id:ibd2058
  • wu:fb73e10
  • wu:fi81c06
  • wu:fk25h01
  • CTNNB
  • MRD19
  • armadillo
  • CHBCAT
  • beta-catenin
  • ctnnb1
Epitope
AA 571-781
42
40
35
32
24
20
19
16
15
15
13
13
12
5
5
4
4
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Chicken, Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
372
259
243
15
12
10
9
9
9
9
5
4
4
2
1
Host
Mouse
325
50
4
Clonality (Clone)
Monoclonal ()
Conjugate
This beta Catenin antibody is un-conjugated
13
11
11
9
9
9
9
9
9
9
9
9
1
1
1
1
Application
Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
255
110
106
80
46
46
45
18
15
13
5
2
1
1
Supplier
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Immunogen Mouse beta-Catenin aa. 571-781
Clone 14-Beta
Isotype IgG1
Cross-Reactivity Human, Chicken, Dog (Canine), Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name beta-Catenin
Background Beta-Catenin is a 92 kDa protein that binds to the cytoplasmic tail of E-Cadherin. The cadherins, transmembrane adhesion molecules, are found with catenins at adherens junctions (zonula adherens). Deletions in the cytoplasmic domain of E-Cadherin which eliminate catenin binding also result in a loss of cell adhesion, indicating that this binding is essential for E-Cadherin function. Although the alpha- and beta-Catenins have been cloned, very little is known about their biochemical roles. However a link between beta-Catenin and colon cancer has been described. beta-Catenin was found to co-immunoprecipitate with the APC tumor suppressor protein in human colorectal tumor cell lines, as well as in human kidney 293 cells. E-Cadherin, however, was not detectable in these complexes. Thus the APC-Catenin complex may be affecting the transmission of contact inhibition signals and/or the regulation of cell adhesion.
Molecular Weight 92 kDa
Pathways
Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20°C.
Supplier Images
Western Blotting (WB) image for anti-beta Catenin antibody (Catenin, beta) (AA 571-781) (ABIN967784) Western blot analysis of beta-Catenin on HeLa cell lysate. Lane 1: 1:500, lane 2: 1:1...
Immunofluorescence (IF) image for anti-beta Catenin antibody (Catenin, beta) (AA 571-781) (ABIN967784) Immunofluorescent staining of A431 cell line with beta-Catenin antibody.
Product cited in: Lee, DAmour, Papkoff: "A yeast model system for functional analysis of beta-catenin signaling." in: The Journal of cell biology, Vol. 158, Issue 6, pp. 1067-78, 2002 (PubMed).

Tateishi, Omata, Tanaka et al.: "The NEDD8 system is essential for cell cycle progression and morphogenetic pathway in mice." in: The Journal of cell biology, Vol. 155, Issue 4, pp. 571-9, 2001 (PubMed).

Persad, Troussard, McPhee et al.: "Tumor suppressor PTEN inhibits nuclear accumulation of beta-catenin and T cell/lymphoid enhancer factor 1-mediated transcriptional activation." in: The Journal of cell biology, Vol. 153, Issue 6, pp. 1161-74, 2001 (PubMed).

Eger, Stockinger, Schaffhauser et al.: "Epithelial mesenchymal transition by c-Fos estrogen receptor activation involves nuclear translocation of beta-catenin and upregulation of beta-catenin/lymphoid enhancer binding factor-1 transcriptional activity." in: The Journal of cell biology, Vol. 148, Issue 1, pp. 173-88, 2000 (PubMed).

Background publications Ozawa, Ringwald, Kemler: "Uvomorulin-catenin complex formation is regulated by a specific domain in the cytoplasmic region of the cell adhesion molecule." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 11, pp. 4246-50, 1990 (PubMed).