TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1 (TIAL1) (AA 161-365) antibody

Details for Product No. ABIN967917
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms TIAL1, TIAR, zgc:66130, tcbp, tiar, TCBP, 5330433G13Rik, AL033329, mTIAR
Epitope
AA 161-365
(2), (2), (2), (1), (1), (1), (1)
Reactivity
Human
(12), (2), (2), (2), (1), (1), (1), (1), (1)
Host
Mouse
(7), (3), (2)
Clonality (Clone)
Monoclonal ()
Application
Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (IHC)
(11), (3), (3), (2), (2), (1)
Pubmed 2 references available
Quantity 50 µg
Options
Shipping to United States (Change)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN967917
Contact our Customer Service for availability and price in your country.
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Human TIAR
Clone 6
Isotype IgG1
Cross-Reactivity Mouse (Murine), Rat (Rattus), Dog (Canine), Frog
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name TIAR
Background TIAR is an RNA-binding protein related to TIA-1. Both proteins are candidate effectors of apoptotic cell death and consist of three N-terminal RNA-recognition motifs (RRM) and a C-terminal protein-interaction domain (PID). Unlike TIA-1, which is localized in the granules of cytotoxic lymphocytes, TIAR is predominantly found in the nucleus of many different cell types. Two related isoforms (42 kDa and 50 kDa) of TIAR have been identified. It has been demonstrated that TIAR can trigger DNA fragmentation in permeabilized thymocytes, suggesting that it may be an effector of apoptotic cell death. During Fas-mediated apoptosis, TIAR shows a rapid translocation from the nucleus to the cytoplasm. This redistribution of TIAR appears to be a specific event and possibly a general feature of the apoptotic program.
Molecular Weight 50 & 42 kDa
Comment

Related Products: ABIN968555, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1 (TIAL1) (AA 161-365) antibody Western blot analysis of TIAR on a mouse macrophage cell lysate. Lane 1: 1:1000, lane 2: 1:2000, lane 3: 1:4000 dilution of the mouse anti-TIAR antibody.
anti-TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1 (TIAL1) (AA 161-365) antibody (2) Immunofluorescence staining of human endothelial cells.
anti-TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1 (TIAL1) (AA 161-365) antibody (3) anti-TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1 (TIAL1) (AA 161-365) antibody (Image 3)
Product cited in: Kawakami, Tian, Duan et al.: "Identification and functional characterization of a TIA-1-related nucleolysin." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 18, pp. 8681-5, 1992 (PubMed).

Taupin, Tian, Kedersha et al.: "The RNA-binding protein TIAR is translocated from the nucleus to the cytoplasm during Fas-mediated apoptotic cell death." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 5, pp. 1629-33, 1995 (PubMed).

Validation Images
Did you look for something else?
back to top