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TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1 (TIAL1) (AA 161-365) antibody

Details for Product No. ABIN967917, Supplier: Login to see
Antigen
  • TIAL1
  • TIAR
  • zgc:66130
  • tcbp
  • tiar
  • TCBP
  • 5330433G13Rik
  • AL033329
  • mTIAR
Epitope
AA 161-365
6
3
2
2
1
1
1
1
1
Reactivity
Dog (Canine), Frog, Human, Mouse (Murine), Rat (Rattus)
21
7
6
6
3
3
3
3
2
2
1
1
1
1
1
Host
Mouse
11
7
3
Clonality (Clone)
Monoclonal ()
Application
Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
20
7
5
3
2
1
1
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Immunogen Human TIAR aa. 161-365
Clone 6-TIAR
Isotype IgG1
Cross-Reactivity Mouse (Murine), Rat (Rattus), Dog (Canine), Frog
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name TIAR (TIAL1 Antibody Abstract)
Background TIAR is an RNA-binding protein related to TIA-1. Both proteins are candidate effectors of apoptotic cell death and consist of three N-terminal RNA-recognition motifs (RRM) and a C-terminal protein-interaction domain (PID). Unlike TIA-1, which is localized in the granules of cytotoxic lymphocytes, TIAR is predominantly found in the nucleus of many different cell types. Two related isoforms (42 kDa and 50 kDa) of TIAR have been identified. It has been demonstrated that TIAR can trigger DNA fragmentation in permeabilized thymocytes, suggesting that it may be an effector of apoptotic cell death. During Fas-mediated apoptosis, TIAR shows a rapid translocation from the nucleus to the cytoplasm. This redistribution of TIAR appears to be a specific event and possibly a general feature of the apoptotic program.
Molecular Weight 50 & 42 kDa
Pathways
Comment

Related Products: ABIN968555, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20° C.
Supplier Images
Western Blotting (WB) image for anti-TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1 (TIAL1) (AA 161-365) antibody (ABIN967917) Western blot analysis of TIAR on a mouse macrophage cell lysate. Lane 1: 1:1000, lane...
Immunofluorescence (IF) image for anti-TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1 (TIAL1) (AA 161-365) antibody (ABIN967917) Immunofluorescence staining of human endothelial cells.
 image for anti-TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1 (TIAL1) (AA 161-365) antibody (ABIN967917) anti-TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1 (TIAL1) (AA 161-365) antibody (Image 3)
Western Blotting (WB) image for anti-TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1 (TIAL1) (AA 161-365) antibody (ABIN967917) anti-TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1 (TIAL1) (AA 161-365) antibody (Image 4)
Product cited in: Taupin, Tian, Kedersha et al.: "The RNA-binding protein TIAR is translocated from the nucleus to the cytoplasm during Fas-mediated apoptotic cell death." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 5, pp. 1629-33, 1995 (PubMed).

Kawakami, Tian, Duan et al.: "Identification and functional characterization of a TIA-1-related nucleolysin." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 18, pp. 8681-5, 1992 (PubMed).