TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1 (TIAL1) (AA 161-365) antibody
Alternatives Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (IHC)
|2 references available|
|Quantity||50 µg (250 µg/ml)|
|Price||Product not available in this region.|
|Cross-Reactivity||Mouse (Murine), Rat (Rattus), Dog (Canine), Frog|
|Description||TIAR is an RNA-binding protein related to TIA-1. Both proteins are candidate effectors of apoptotic cell death and consist of three N-terminal RNA-recognition motifs (RRM) and a C-terminal protein-interaction domain (PID). Unlike TIA-1, which is localized in the granules of cytotoxic lymphocytes, TIAR is predominantly found in the nucleus of many different cell types. Two related isoforms (42 kDa and 50 kDa) of TIAR have been identified. It has been demonstrated that TIAR can trigger DNA fragmentation in permeabilized thymocytes, suggesting that it may be an effector of apoptotic cell death. During Fas-mediated apoptosis, TIAR shows a rapid translocation from the nucleus to the cytoplasm. This redistribution of TIAR appears to be a specific event and possibly a general feature of the apoptotic program.|
1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
|Molecular Weight||50 & 42 kDa|
Related Products: ABIN968555, ABIN967389
|Purification||Purified from tissue culture supernatant or ascites by affinity chromatography.|
|Buffer||Aqueous buffered solution containing BSA, glycerol.|
|Preservative||0.09% Sodium azide.|
|Storage||Store undiluted at -20° C.|
|Restrictions||For Research Use only|
Kawakami, Tian, Duan et al.: "Identification and functional characterization of a TIA-1-related nucleolysin." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 18, pp. 8681-5, 1992 (PubMed).
Taupin, Tian, Kedersha et al.: "The RNA-binding protein TIAR is translocated from the nucleus to the cytoplasm during Fas-mediated apoptotic cell death." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 5, pp. 1629-33, 1995 (PubMed).
|Hosts||Rabbit (3), Goat (2)|
|Reactivities||Human (5), Dog (Canine) (2), Mouse (Murine) (2), Chicken (1), Cow (Bovine) (1), Rat (Rattus) (1), Xenopus laevis (1), Zebrafish (1)|
|Applications||Western Blotting (WB) (5), ELISA (2)|
|Epitopes||C-Term (1), Internal Region (1)|