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Synaptotagmin (AA 72-223) antibody

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Synonyms Syti, GB20036, DKFZP459P193, SYT1, SytI
AA 72-223
(20), (15), (13), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Rat (Rattus)
(76), (71), (62), (9), (8), (4), (4), (3), (2), (2), (1)
(83), (8)
Clonality (Clone)
Monoclonal ()
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB)
(65), (50), (24), (20), (11), (7), (5), (5), (1)
Pubmed 6 references available
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Quantity 50 μg
Shipping to United States ( )
Immunogen Rat Synaptotagmin
Clone BC17
Isotype IgG1
Cross-Reactivity Human
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Background Synaptotagmin (p65) is an abundant synaptic vesicle protein that contains a single transmembrane region and two copies of an internal repeat that is homologous to the regulatory region of Protein Kinase C. It appears that synaptotagmin has a regulatory role in the synaptic vesicle pathway, particularly in vesicle docking and/or fusion with the plasmalemma. A model has been proposed to explain docking, activation, and fusion of synaptic vesicles with donor membranes. This model suggests that VAMP/synaptobrevin and synaptotagmin (vSNARE) on the synaptic vesicle, and SNAP-25 and syntaxin (tSNAREs) on the plasma membrane, interact to form a 7S complex. Two additional soluble proteins, alphaSNAP and NSF, are later added to the 7S complex, accompanied by the loss of synaptotagmin. The resulting 20S complex contains syntaxin, SNAP-25, VAMP, alphaSNAP, and NSF. Genetic studies in several species demonstrate that mutation or deletion of synaptotagmin results in a large decrease in Ca2+ triggered transmitter release. Mammalian synapses that lack synaptotagmin show a selective decrease in a fast component of release, suggesting that synaptotagmin is the Ca2+ sensor triggering exocytosis.
Molecular Weight 65 kDa
Research Area Cancer

Related Products: ABIN968545, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
Western Blotting (WB) image for anti-Synaptotagmin (AA 72-223) antibody (ABIN967965) Western blot analysis of Synaptotagmin on rat brain lysate. Lane 1: 1:1000, lane 2: 1...
Product cited in: Liu, Fallon, Lashuel et al.: "The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility." in: Cell, Vol. 111, Issue 2, pp. 209-18, 2002 (PubMed).

Ramalho-Santos, Moreno, Sutovsky et al.: "SNAREs in mammalian sperm: possible implications for fertilization." in: Developmental biology, Vol. 223, Issue 1, pp. 54-69, 2000 (PubMed).

Duncan, Don-Wauchope, Tapechum et al.: "High-efficiency Semliki Forest virus-mediated transduction in bovine adrenal chromaffin cells." in: The Biochemical journal, Vol. 342 Pt 3, pp. 497-501, 1999 (PubMed).

Scheller: "Membrane trafficking in the presynaptic nerve terminal." in: Neuron, Vol. 14, Issue 5, pp. 893-7, 1995 (PubMed).

Perin, Johnston, Ozcelik et al.: "Structural and functional conservation of synaptotagmin (p65) in Drosophila and humans." in: The Journal of biological chemistry, Vol. 266, Issue 1, pp. 615-22, 1991 (PubMed).

Background publications Connolly, Chait, Duncan et al.: "CT-guided percutaneous needle biopsy of small lung nodules in children." in: Pediatric radiology, Vol. 29, Issue 5, pp. 342-6, 1999 (PubMed).

Catalog No. ABIN967965
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