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NUP62 antibody (AA 24-178)

NUP62 Reactivity: Human, Mouse, Rat, Chicken WB, IHC, IF, IP Host: Mouse Monoclonal 53-Nucleoporin p62 unconjugated
Catalog No. ABIN968004
  • Target See all NUP62 Antibodies
    NUP62 (Nucleoporin 62kDa (NUP62))
    Binding Specificity
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 24-178
    Reactivity
    • 44
    • 14
    • 14
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Chicken
    Host
    • 36
    • 6
    • 1
    • 1
    Mouse
    Clonality
    • 37
    • 7
    Monoclonal
    Conjugate
    • 34
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This NUP62 antibody is un-conjugated
    Application
    • 34
    • 12
    • 9
    • 9
    • 8
    • 6
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
    Cross-Reactivity
    Chicken, Mouse (Murine), Rat (Rattus)
    Characteristics
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human Nucleoporin aa. 24-178
    Clone
    53-Nucleoporin p62
    Isotype
    IgG2b
    Top Product
    Discover our top product NUP62 Primary Antibody
  • Comment

    Related Products: ABIN968535, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store undiluted at -20° C.
  • Paroni, Henderson, Schneider, Brancolini: "Caspase-2 can trigger cytochrome C release and apoptosis from the nucleus." in: The Journal of biological chemistry, Vol. 277, Issue 17, pp. 15147-61, (2002) (PubMed).

    Shah, Patel, Fried, Sehgal: "Interactions of STAT3 with caveolin-1 and heat shock protein 90 in plasma membrane raft and cytosolic complexes. Preservation of cytokine signaling during fever." in: The Journal of biological chemistry, Vol. 277, Issue 47, pp. 45662-9, (2002) (PubMed).

    Daigle, Beaudouin, Hartnell, Imreh, Hallberg, Lippincott-Schwartz, Ellenberg: "Nuclear pore complexes form immobile networks and have a very low turnover in live mammalian cells." in: The Journal of cell biology, Vol. 154, Issue 1, pp. 71-84, (2001) (PubMed).

    Iborra, Jackson, Cook: "The path of RNA through nuclear pores: apparent entry from the sides into specialized pores." in: Journal of cell science, Vol. 113 Pt 2, pp. 291-302, (2000) (PubMed).

  • Target
    NUP62 (Nucleoporin 62kDa (NUP62))
    Alternative Name
    Nucleoporin p62 (NUP62 Products)
    Synonyms
    IBSN antibody, SNDI antibody, p62 antibody, NUP62 antibody, AA589433 antibody, AI426861 antibody, AI790512 antibody, AU045898 antibody, D7Ertd649e antibody, Nupc1 antibody, CG6251 antibody, Dmel\\CG6251 antibody, DDBDRAFT_0167902 antibody, DDBDRAFT_0237712 antibody, DDB_0167902 antibody, DDB_0237712 antibody, nup62 antibody, Np62 antibody, nucleoporin 62 antibody, hypothetical protein antibody, nucleoporin 62kDa antibody, Nucleoporin 62kD antibody, predicted protein antibody, nuclear pore protein antibody, Nup62 nuclear pore complex glycoprotein p62-related protein (IC) antibody, Nuclear pore glycoprotein p62 antibody, NUP62 antibody, PGTG_03077 antibody, Nup62 antibody, nup62 antibody
    Background
    The nuclear pore complex (NPC) acts as a gate to mediate active transport of proteins and RNA into and out of the nucleus. Proteins actively transported into the nucleus through the NPC require specific nuclear localization sequences. Many of these nucleoporins contain N-acetylglucosamine (GlcNAc) residues that are O-linked to serine or threonine. p62 is the best characterized member of a group of nucleoporins that line the central region of the NPC. A tightly associated complex is formed by p62 and two other nucleoporins, p54 and p58. p54 binds to a carboxy-terminal coiled-coil domain of p62 and p58 binds to a dimer of p54. The amino-terminal domain of p62 contains a series of XFXFX repeats and is joined to the coiled-coil domain by a threonine-rich linker segment. The major role of p62 is maintenance of the structural integrity of NPCs.
    Molecular Weight
    62 kDa
    Pathways
    EGFR Signaling Pathway, SARS-CoV-2 Protein Interactome
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