Integrin alpha 2 (ITGA2) (AA 42-245) antibody

Details for Product No. ABIN968317
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Synonyms PGI, gpi, pgi-1, wu:fc02c05, zgc:86919, CD49B, DX5, BR, GPIa, HPA-5, VLA-2, VLAA2
AA 42-245
(32), (15), (14), (10), (6), (3), (2), (2), (1), (1), (1), (1), (1), (1)
(190), (81), (13), (1)
(111), (76), (55), (23), (2), (1)
Clonality (Clone)
Monoclonal ()
(42), (33), (28), (10), (8), (7), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB), Immunofluorescence (IF)
(180), (81), (55), (50), (29), (25), (23), (23), (15), (12), (11), (10), (8), (5), (3), (1), (1), (1)
Pubmed 5 references available
Quantity 50 μg
Shipping to United States (Change)
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Catalog No. ABIN968317
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Immunogen Human VLA-2alpha
Clone 2
Isotype IgG2a, kappa
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name CD49b
Background Integrins are a family of dimeric proteins that mediate cell-to-cell and extracellular matrix adhesion. They consist of a large alpha chain that is non-covalently associated with a smaller beta chain which is used to define integrin subfamilies. These molecules exhibit a wide range of expression throughout development and adulthood. VLA-2 (very late antigen), a member of the integrin superfamily, was identified on activated T cells, but has since been reported to be on various cell types. VLA-2 is reported to be a heterodimer of integrin alpha2 (CD49b) and integrin beta1 (CD29) subunits. The alpha2 chain contains a large extracellular domain, a transmembrane domain, and a short cytoplasmic tail. VLA-2 functions as a collagen receptor on platelets and fibroblasts, as well as a collagen and laminin receptor on endothelial and epithelial cells. On activated T cells, VLA-2, like LFA-1, exhibits increased number and affinity of ligand binding. Interactions of these molecules with their extracellular matrix ligands is important for directing effector T cells to their target tissues and to provide co-stimulatory signals. Thus, VLA-2 not only plays an important role in cellular adhesion, but may function in intracellular signal transmission. This antibody is routinely tested by western blot analysis.
Synonyms: Integrin alpha2, VLA-2alpha
Molecular Weight 150 kDa
Research Area CD Antigens, Surface Receptors of Immune Cells

Related Products: ABIN968535, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-Integrin alpha 2 (ITGA2) (AA 42-245) antibody Immunofluorescence staining of WiDr cells (Human colorectal adenocarcinoma, ATCC CCL-218).
anti-Integrin alpha 2 (ITGA2) (AA 42-245) antibody (2) Western blot analysis of CD49b (Integrin alpha2) on a HeLa cell lysate (Human cervical epitheloid carcinoma, ATCC CCL-2.2). Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of the anti-human CD49b antibody.
Product cited in: Förster, Mäkela, Wärri et al.: "Involvement of estrogen receptor beta in terminal differentiation of mammary gland epithelium." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 24, pp. 15578-83, 2002 (PubMed).

Russell, Tofilon: "Radiation-induced activation of nuclear factor-kappaB involves selective degradation of plasma membrane-associated I(kappa)B(alpha)." in: Molecular biology of the cell, Vol. 13, Issue 10, pp. 3431-40, 2002 (PubMed).

Emsley, King, Bergelson et al.: "Crystal structure of the I domain from integrin alpha2beta1." in: The Journal of biological chemistry, Vol. 272, Issue 45, pp. 28512-7, 1997 (PubMed).

Wu, Santoro: "Complex patterns of expression suggest extensive roles for the alpha 2 beta 1 integrin in murine development." in: Developmental dynamics : an official publication of the American Association of Anatomists, Vol. 199, Issue 4, pp. 292-314, 1994 (PubMed).

Takada, Hemler: "The primary structure of the VLA-2/collagen receptor alpha 2 subunit (platelet GPIa): homology to other integrins and the presence of a possible collagen-binding domain." in: The Journal of cell biology, Vol. 109, Issue 1, pp. 397-407, 1989 (PubMed).

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