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Integrin, alpha 3 (Antigen CD49C, alpha 3 Subunit of VLA-3 Receptor) (ITGA3) (AA 110-325) antibody

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Synonyms ITGA3, CD11c, AA407068, CD49C, GAPB3, GAP-B3, ILNEB, MSK18, VCA-2, VL3A, VLA3a
AA 110-325
(17), (13), (6), (5), (4), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Dog (Canine), Mouse (Murine), Rat (Rattus)
(151), (36), (25), (3), (3), (1), (1)
(89), (59), (4), (2)
Clonality (Clone)
Monoclonal ()
(20), (17), (7), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunofluorescence (IF), Western Blotting (WB)
(74), (51), (32), (24), (23), (21), (18), (13), (11), (10), (5), (3), (2), (2)
Pubmed 2 references available
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Quantity 50 μg
Shipping to United States ( )
Immunogen Mouse VLA-3alpha aa. 110-325
Clone 42-CD49c
Isotype IgG1
Cross-Reactivity Rat (Rattus), Dog (Canine)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name CD49c (ITGA3 Antibody Abstract)
Background Integrins are a family of dimeric proteins that mediate cell-to-cell and extracellular matrix adhesion. They consist of a large alpha chain that is non-covalently associated with a smaller beta chain which defines the integrin subfamilies. VLA-3 (Very Late Antigen-3), a member of the integrin superfamily, exhibits elevated expression on B lymphocytes, but is also found on monocytes, platelets, and hematopoietic progenitor cells. A heterodimer of alpha3 (CD49c) and beta1 (CD29) subunits, VLA is a receptor for laminin, fibronectin, and collagen. The alpha3 chain contains a large extracellular domain with three putative metal-binding sequences, a transmembrane domain, and a short cytoplasmic tail. Differing requirements for divalent cations and the influence of RGD peptides results in multiple ligand-binding mechanisms for VLA-3. Although its expression is restricted in normal tissues, VLA-3 is found on a variety of cultured tumor cells. In addition, levels of VLA-3 have been shown to correlate with the degree of invasiveness of malignant melanoma cells. Thus, VLA-3 mediates intercellular adhesion and cell migration in normal and, possibly, cancerous cell types.
Synonyms: Integrin alpha3, VLA-3alpha
Molecular Weight 135 kDa

Related Products: ABIN968547, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20° C.
Supplier Images
Western Blotting (WB) image for anti-Integrin, alpha 3 (Antigen CD49C, alpha 3 Subunit of VLA-3 Receptor) (ITGA3) (AA 110-325) antibody (ABIN968338) Western blot analysis of CD49c (integrin alpha3) on a rat kidney lysate. Lane 1: 1:25...
Immunofluorescence (IF) image for anti-Integrin, alpha 3 (Antigen CD49C, alpha 3 Subunit of VLA-3 Receptor) (ITGA3) (AA 110-325) antibody (ABIN968338) Immunofluorescence staining of MDCK cells (canine kidney, ATCC CCL-34).
Product cited in: Takeuchi, Hirano, Tsuji et al.: "cDNA cloning of mouse VLA-3 alpha subunit." in: Journal of cellular biochemistry, Vol. 57, Issue 2, pp. 371-7, 1995 (PubMed).

Takada, Murphy, Pil et al.: "Molecular cloning and expression of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen." in: The Journal of cell biology, Vol. 115, Issue 1, pp. 257-66, 1991 (PubMed).

Catalog No. ABIN968338
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