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Details for Product No. ABIN968502

Citron (Rho-Interacting, serine/threonine Kinase 21) (CIT) (AA 1420-1612) antibody

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Antigen
Synonyms CRIK, STK21, C030025P15Rik, CRIK-SK, Cit-k, CIT, crik, xcit, stk21
Epitope
»Alternatives AA 1420-1612
Reactivity
»Alternatives Mouse (Murine)
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Application
»Alternatives Western Blotting (WB), Immunofluorescence (IF)
Pubmed 4 references available
Catalog no. ABIN968502
Quantity 50 µg
Price
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Immunogen Mouse CRIK
Clone 6
Isotype IgG1
Cross-Reactivity Human, Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
5. For fluorochrome spectra and suitable instrument settings, please refer to us.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name CRIK
Background Citron was identified by its interactions with activated Rho and Rac. It contains a zinc finger (ZF) region, a pleckstrin homology (PH) domain, a citron/MRCK/Gek (CMG) domain, and a coiled-coil domain with a Rho-Rac binding region (RRB). Citron binds to PSD-95 via its C-terminal tSXV motif and the PDZ domain on PSD-95. This association occurs at post synaptic densities where citron-PSD-95 may provide a specific link between the Rho signaling cascade and the synaptic NMDA receptor complex. Citron Rho-interacting kinase (CRIK) and CRIK short kinase (CRIK-SK) are Ser/Thr kinase isoforms of the myotonic dystrophy kinase family. CRIK contains full-length citron, with an N-terminal kinase domain. CRIK-SK is a splice variant that contains only the kinase domain. CRIK co-localizes with actin in keratinocytes and co-expression of CRIK and Rho increases CRIK kinase activity two-fold. In addition, CRIK mutants cause abnormal contraction during cytokinesis. CRIK is expressed highest in testis, but is also present in brain, spleen, lung, and kidney. Thus, CRIK is a Ser/Thr kinase that functions downstream of Rho during events such as cytokinesis and synaptic transmission.
Synonyms: Serine/Threonine Protein Kinase 21
Molecular Weight 240 kDa
Comment

Related Products: ABIN968539, ABIN967389, ABIN968537

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Storage -20 °C
Product cited in: Madaule, Eda, Watanabe et al.: "Role of citron kinase as a target of the small GTPase Rho in cytokinesis." in: Nature, Vol. 394, Issue 6692, pp. 491-4, 1998 (PubMed).

Di Cunto, Calautti, Hsiao et al.: "Citron rho-interacting kinase, a novel tissue-specific ser/thr kinase encompassing the Rho-Rac-binding protein Citron." in: The Journal of biological chemistry, Vol. 273, Issue 45, pp. 29706-11, 1998 (PubMed).

Zhang, Vazquez, Apperson et al.: "Citron binds to PSD-95 at glutamatergic synapses on inhibitory neurons in the hippocampus." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 19, Issue 1, pp. 96-108, 1999 (PubMed).

Furuyashiki, Fujisawa, Fujita et al.: "Citron, a Rho-target, interacts with PSD-95/SAP-90 at glutamatergic synapses in the thalamus." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 19, Issue 1, pp. 109-18, 1999 (PubMed).

Alternatives for antigen "Citron (Rho-Interacting, serine/threonine Kinase 21) (CIT)", type "Antibodies"
Hosts (7), (1)
Reactivities (8), (2), (2)
Applications (6), (5), (3), (2), (1), (1)
Epitopes (1), (1)
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