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Vesicle Transport through Interaction with T-SNAREs Homolog 1B (Yeast) (VTI1B) (AA 9-121) antibody

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Synonyms zgc:63525, VTI1B, VTI1, VTI1-LIKE, VTI1L, VTI2, v-SNARE, vti1-rp1, AU015348, GES30, MVti1b, SNARE, Vti1-rp1
AA 9-121
(19), (15), (11), (4), (4), (3), (3), (2), (1), (1), (1), (1), (1), (1)
Human, Mouse (Murine), Rat (Rattus)
(66), (14), (14), (3), (1), (1)
(46), (16), (4)
Clonality (Clone)
Monoclonal ()
(5), (5), (5), (3), (3), (3)
Immunofluorescence (IF), Western Blotting (WB)
(53), (39), (9), (3), (2), (1), (1)
Pubmed 5 references available
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Quantity 50 μg
Shipping to United States ( )
Immunogen Mouse Vti1b aa. 9-121
Clone 7-Vti1b
Isotype IgG1
Cross-Reactivity Human, Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name Vti1b (VTI1B Antibody Abstract)
Background Eukaryotic protein trafficking involves packaging of target molecules into membranous vesicles that bud from a donor compartment, travel to a specific destination, fuse, and release their contents into an acceptor compartment. Recognition between vesicle and acceptor membrane is mediated by the pairing of the integral membrane SNARE proteins. The stable interaction between vesicle proteins (v-SNAREs, VAMP1, VAMP2) and target proteins (t-SNAREs, syntaxin 1, SNAP-25) juxtaposes the membranes and results in an activated docked state and/or membrane fusion. With the identification of all SNARE family members in yeast, the research focus has turned to mammalian cells. Here, sequence analysis has identified additional SNARE proteins, including VTI1a and VTI1b. In line with their involvement in vesicle transport, these molecules are expressed in a wide range of mammalian tissues. VTI1b is a membrane bound protein whose localization overlaps with the cis/medial Golgi marker mannosidase II and the trans-Golgi marker syntaxin 6. VTI1b interacts with, and disrupts the localization of, syntaxin 5. Thus, VTI1b is thought to function in the regulation of post-Golgi vesicle trafficking.
Molecular Weight 27 kDa

Related Products: ABIN968536, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20° C.
Supplier Images
Western Blotting (WB) image for anti-Vesicle Transport through Interaction with T-SNAREs Homolog 1B (Yeast) (VTI1B) (AA 9-121) antibody (ABIN968520) Western blot analysis of Vti1b on a human endothelial cell lysate. Lane 1: 1:1000, la...
Immunofluorescence (IF) image for anti-Vesicle Transport through Interaction with T-SNAREs Homolog 1B (Yeast) (VTI1B) (AA 9-121) antibody (ABIN968520) Immunofluorescence staining of NIH/3T3 cells (Mouse embryo fibroblast cells, ATCC CRL...
Product cited in: Chen, Manga, Orlow: "Pink-eyed dilution protein controls the processing of tyrosinase." in: Molecular biology of the cell, Vol. 13, Issue 6, pp. 1953-64, 2002 (PubMed).

Shorter, Beard, Seemann et al.: "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115." in: The Journal of cell biology, Vol. 157, Issue 1, pp. 45-62, 2002 (PubMed).

Mallard, Tang, Galli et al.: "Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform." in: The Journal of cell biology, Vol. 156, Issue 4, pp. 653-64, 2002 (PubMed).

Yang, Gonzalez, Prekeris et al.: "SNARE interactions are not selective. Implications for membrane fusion specificity." in: The Journal of biological chemistry, Vol. 274, Issue 9, pp. 5649-53, 1999 (PubMed).

Advani, Bae, Bock et al.: "Seven novel mammalian SNARE proteins localize to distinct membrane compartments." in: The Journal of biological chemistry, Vol. 273, Issue 17, pp. 10317-24, 1998 (PubMed).

Catalog No. ABIN968520
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