Mitogen-Activated Protein Kinase 14 (MAPK14) (AA 243-355) antibody

Details for Product No. ABIN968770
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Antigen
Synonyms
p38b, zp38b, MAPK14, p38, 186F5S, BG:DS00797.3, CG7393, D-p38, D-p38 MAPK, D-p38b, Dm p38b, Dmel\\CG7393, Dmp38b, Dp38, Dp38b, ESTS:186F5S, Mpk34C, anon-sts23, dp38b, p38 MAPK, p38 beta, p38B, p38Kb,  ... show more
p38b, zp38b, MAPK14, p38, 186F5S, BG:DS00797.3, CG7393, D-p38, D-p38 MAPK, D-p38b, Dm p38b, Dmel\\CG7393, Dmp38b, Dp38, Dp38b, ESTS:186F5S, Mpk34C, anon-sts23, dp38b, p38 MAPK, p38 beta, p38B, p38Kb, p38beta, GADS, GRAP-2, GRB2L, GRBLG, GRID, GRPL, GrbX, Grf40, Mona, P38, CRK1, CSBP, CSPB1, Csbp1, Csbp2, Exip, Hog, Mxi2, Prkm14, Prkm15, RK, Sapk2A, p38Hog, p38alpha, CSBP1, CSBP2, EXIP, PRKM14, PRKM15, SAPK2A, p38ALPHA, Crk1, p38-alpha, p38MAPK, p38a, csbp, mapk14a, mxi2, sapk2, sapk2a, AP22.98, AP22_98, ATMPK14, mitogen-activated protein kinase 14, SAPK2a, fk28c03, hm:zeh1243, wu:fk28c03, zp38a, P38C-CRK show less
Epitope
AA 243-355
(90), (76), (22), (17), (16), (14), (12), (12), (10), (9), (7), (6), (5), (4), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(347), (221), (214), (77), (47), (41), (13), (10), (5), (5), (5), (5), (4), (3), (1), (1), (1), (1)
Host
Mouse
(308), (50), (2), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(8), (8), (7), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunofluorescence (IF)
(290), (136), (98), (63), (50), (45), (27), (17), (10), (9), (9), (3), (2), (1), (1), (1), (1)
Pubmed 4 references available
Quantity 150 µg
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Catalog No. ABIN968770
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Immunogen Human p38 MAPK
Clone MK-1-410
Isotype IgG1
Cross-Reactivity Dog (Canine), Mouse (Murine), Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name p38alpha
Background Activation of the immune and inflammatory responses often involves the recognition of bacterial endotoxin (lipopolysaccharide or LPS). Binding of LPS by monocytic cells results in the production and release of proinflammatory cytokines, such as IL-1 and TNF-alpha. LPS-induced signaling cascades involve members of the Ser/Thr protein kinase family known as the mitogen activated protein kinases (MAPKs). One of these, p38 MAP kinase (p38 MAPK or CSPB2), is a human homologue of HOG1, a yeast MAP kinase that is essential for growth under conditions of elevated osmolarity. Similar to HOG1, p38 MAPK is phosphorylated in response to hyperosmolarity, but also in response to a variety of stimuli including LPS, IL-1, or TNF-alpha. Efficient activation of p38 MAPK requires phosphorylation of Thr-180 and Tyr-182. At least three Thr/Tyr kinases (MKK3, MKK4/SEK1, and MKK6) phosphorylate and activate p38 MAPK. This leads to the activation of multiple transcription factors (NF-kappaB, ATF-2, Elk-1, and CHOP/GADD143) that induce expression of proinflammatory cytokine genes. In addition to its role in immunity, p38 MAPK is widely expressed and serves as an important signal transducer in a variety of cell types. This antibody is routinely tested by western blot analysis.
Synonyms: SAPK2a
Molecular Weight 42 kDa
Comment

Related Products: ABIN968537, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-Mitogen-Activated Protein Kinase 14 (MAPK14) (AA 243-355) antibody Immunofluorescence staining of HeLa cells.
anti-Mitogen-Activated Protein Kinase 14 (MAPK14) (AA 243-355) antibody (2) Western blot analysis of p38alpha on a Jurkat lysate. Lane 1: 1:5000, lane 2: 1:10000, lane 3: 1:20000 dilution of the anti- p38alpha antibody.
Product cited in: Han, Lee, Bibbs et al.: "A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells." in: Science (New York, N.Y.), Vol. 265, Issue 5173, pp. 808-11, 1994 (PubMed).

Brunet, Pouysségur: "Identification of MAP kinase domains by redirecting stress signals into growth factor responses." in: Science (New York, N.Y.), Vol. 272, Issue 5268, pp. 1652-5, 1996 (PubMed).

Winston, Chan, Johnson et al.: "Activation of p38mapk, MKK3, and MKK4 by TNF-alpha in mouse bone marrow-derived macrophages." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 159, Issue 9, pp. 4491-7, 1997 (PubMed).

Morinobu, Gadina, Strober et al.: "STAT4 serine phosphorylation is critical for IL-12-induced IFN-gamma production but not for cell proliferation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 19, pp. 12281-6, 2002 (PubMed).

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