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Actin Related Protein 2/3 Complex, Subunit 3, 21kDa (ARPC3) (AA 10-118) antibody

Details for Product No. ABIN968781
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Antigen
Synonyms DDBDRAFT_0184576, DDBDRAFT_0201632, DDB_0184576, DDB_0201632, arc21, p21-arc, 1110006A04Rik, 21kDa, AA408672, AI788639, p21-Ar, p21Arc, zgc:86828, ARC21, p21-Arc
Epitope
AA 10-118
(5), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(29), (8), (6), (2), (2), (1), (1), (1), (1), (1)
Host
Mouse
(23), (6), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2)
Application
Western Blotting (WB), Immunofluorescence (IF)
(30), (17), (9), (4), (1)
Pubmed 2 references available
Quantity 50 µg
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Catalog No. ABIN968781
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Immunogen Human p21-Arc
Clone MK-1-25
Isotype IgG1
Cross-Reactivity Mouse (Murine), Rat (Rattus), Chicken, Dog (Canine)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name p21-Arc
Background Cellular morphology, adhesion, and motility occur through the reorganization of the actin cytoskeleton. This reorganization of actin filaments occurs through the interactions between actin and actin binding proteins. Actin-binding proteins regulate the polymerization and depolymerization of actin, connect actin-based structures to membranes and to other cytoskeletal elements, power the movement of actin filaments, and cross-link actin filaments into bundles. Actin related proteins (Arp) 2/3 complex is an actin polymerization inducing complex that includes Arp2, Arp3, p41-Arc, p34-Arc, p21-Arc, p20 Arc, and p16-Arc. The Arp2 and Arp3 subunits may nucleate actin polymerization, while the p41-Arc subunit is a WD repeat-containing protein that may regulate both the activity and localization of the Arp2/3 complex. Arp3, p34-Arc, and p21-Arc are localized to the lamellipodia of stationary and locomoting fibroblasts. Both WASP and Abp1p are acidic sequence-containing proteins that activate the Arp2/3 complex. However, WASP binds actin monomers, while the endocytosis-related Abp1p protein binds actin filaments. Thus, Arp2/3 complex may regulate actin polymerization in specific cell locations through interaction with actin binding Arp2/3 activators.
Molecular Weight 21 kDa
Comment

Related Products: ABIN968535, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-Actin Related Protein 2/3 Complex, Subunit 3, 21kDa (ARPC3) (AA 10-118) antibody Western blot analysis of p21-Arc on a HeLa cell lysate (Human cervical epitheloid carcinoma, ATCC CCL-2.2). Lane 1: 1:1000, lane 2: 1:2000, lane 3: 1:4000 dilution of the mouse anti- p21-Arc antibody.
anti-Actin Related Protein 2/3 Complex, Subunit 3, 21kDa (ARPC3) (AA 10-118) antibody (2) Immunofluorescence staining of HeLa cells (Human cervical epitheloid carcinoma, ATCC CCL-2.2).
Product cited in: Welch, DePace, Verma et al.: "The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly." in: The Journal of cell biology, Vol. 138, Issue 2, pp. 375-84, 1997 (PubMed).

Zhao, Yang, Qian et al.: "Interactions among subunits of human Arp2/3 complex: p20-Arc as the hub." in: Biochemical and biophysical research communications, Vol. 280, Issue 2, pp. 513-7, 2001 (PubMed).

Validation Images
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