Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) (BMPR2) (AA 803-996) antibody

Details for Product No. ABIN968806
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Synonyms BMPR-II, BMPR3, BMR2, BRK-3, PPH1, T-ALK, 2610024H22Rik, AL117858, AW546137, BB189135, BMP-2, BMPR-2, BMPRII, Gm20272, Bmpr-II, bmprii
AA 803-996
(36), (14), (12), (12), (4), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Human, Mouse (Murine), Rat (Rattus)
(106), (37), (32), (10), (1)
(83), (21), (2)
Clonality (Clone)
Monoclonal ()
(6), (6), (5), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1)
Immunofluorescence (IF), Western Blotting (WB)
(72), (57), (53), (34), (15), (11), (10), (9), (6), (3), (1)
Pubmed 3 references available
Quantity 50 μg
Shipping to United States ( )
Immunogen Mouse BMPR-II aa. 803-996
Clone 18-BMPR
Isotype IgG1
Cross-Reactivity Human, Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name BMPR-II (BMPR2 Antibody Abstract)
Background The transforming growth factor beta (TGFbeta)/activin/BMP family of growth factor plays a diverse and important role in growth, development, and differentiation. The receptors for this famiy of proteins are type I and II ser/thr kinase receptors. Bone morphogenetic protein receptors (BMPRs) include two type I receptors, BMPR-IA and BMPR-IB, and a type II receptor, BMPR-II. BMPR-II is a widely expressed receptor, with high mRNA expression during development in many tissues. BMPR-II transfected COS-1 cells show binding to BMP-7 (osteogenic protein-1) and BMP-4, and co-transfection with the type I receptor, ActR-I, leads to transcriptional activation in response to BMP-7. In addition, extracellular matrix proteins may regulate the expression of BMPR-II during angiogenesis, since fibrillar type I collagen induces BMPR-II expression in endothelial cells. In familial primary pulmonary hypertension, the BMPR-II gene is mutated in a manner that may disrupt ligand binding, kinase activity, and heteromeric dimer formation. Thus, BMPR-II may be an important mediator of BMP effects during growth and differentiation of endothelial cells.
Molecular Weight 130 kDa

Related Products: ABIN968540, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20°C.
Supplier Images
Western Blotting (WB) image for anti-Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) (BMPR2) (AA 803-996) antibody (ABIN968806) Western blot analysis of BMPR-II on mouse cerebrum lysate. Lane 1: 1:250, lane 2 :1:5...
Product cited in: Regazzoni, Winterhalter, Rohrer: "Type I collagen induces expression of bone morphogenetic protein receptor type II." in: Biochemical and biophysical research communications, Vol. 283, Issue 2, pp. 316-22, 2001 (PubMed).

, Lane, Machado et al.: "Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension." in: Nature genetics, Vol. 26, Issue 1, pp. 81-4, 2000 (PubMed).

Rosenzweig, Imamura, Okadome et al.: "Cloning and characterization of a human type II receptor for bone morphogenetic proteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 17, pp. 7632-6, 1995 (PubMed).

Catalog No. ABIN968806
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