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Gephyrin antibody (AA 569-726)

GPHN Reactivity: Human, Mouse, Chicken, Blow Fly WB, IHC, IF, IP Host: Mouse Monoclonal 45-Gephyrin unconjugated
Catalog No. ABIN968898
  • Target See all Gephyrin (GPHN) Antibodies
    Gephyrin (GPHN)
    Binding Specificity
    • 7
    • 7
    • 6
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 569-726
    Reactivity
    • 52
    • 34
    • 26
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    Human, Mouse, Chicken, Blow Fly
    Host
    • 48
    • 5
    • 1
    • 1
    Mouse
    Clonality
    • 43
    • 12
    Monoclonal
    Conjugate
    • 28
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This Gephyrin antibody is un-conjugated
    Application
    • 36
    • 19
    • 17
    • 16
    • 6
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
    Cross-Reactivity
    Human, Mouse (Murine), Chicken, Fruit Fly (Drosophila melanogaster)
    Characteristics
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Rat Gephyrin aa. 569-726
    Clone
    45-Gephyrin
    Isotype
    IgG1
    Top Product
    Discover our top product GPHN Primary Antibody
  • Comment

    Related Products: ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store undiluted at -20°C.
  • Meyer, Kirsch, Betz, Langosch: "Identification of a gephyrin binding motif on the glycine receptor beta subunit." in: Neuron, Vol. 15, Issue 3, pp. 563-72, (1995) (PubMed).

    Prior, Schmitt, Grenningloh, Pribilla, Multhaup, Beyreuther, Maulet, Werner, Langosch, Kirsch: "Primary structure and alternative splice variants of gephyrin, a putative glycine receptor-tubulin linker protein." in: Neuron, Vol. 8, Issue 6, pp. 1161-70, (1992) (PubMed).

  • Target
    Gephyrin (GPHN)
    Alternative Name
    Gephyrin (GPHN Products)
    Synonyms
    5730552E08Rik antibody, AI662856 antibody, BC027112 antibody, C230040D23 antibody, GPH antibody, GPHRYN antibody, geph antibody, Geph antibody, GPHN antibody, GEPH antibody, HKPX1 antibody, gpgb1 antibody, DKFZp459M0825 antibody, gephyrin antibody, gephyrin L homeolog antibody, gephyrin a antibody, Gphn antibody, GPHN antibody, gphn.L antibody, gphna antibody, PTRG_08978 antibody, VDBG_00775 antibody, Tsp_03043 antibody, gphn antibody
    Background
    The sub-membraneous region of the postsynaptic neuron is an intricate network of cytoskeletal elements generally known as the postsynaptic density. It is thought that this elaborate cytoskeletal region is critical for receptor targeting, clustering, and efficient signal input. Gephyrin, a 93 kDa protein, was identified as a result of its ability to bind to polymerized tubulin (microtubules). Although expressed in all tissues, gephyrin mRNA is found most abundantly in brain. Alternative splicing produces at least five different mRNAs. Gephyrin colocalizes and interacts with the glycine receptor at the postsynaptic density. It is possible that Gephyrin acts as an anchor between the glycine receptor and microtubules.
    Molecular Weight
    93 kDa
    Pathways
    Synaptic Membrane, Skeletal Muscle Fiber Development
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