Keratin 5 (KRT5) antibody

Details for Product No. ABIN969078
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Antigen
Synonyms CK5, DDD, DDD1, EBS2, K5, KRT5A, Tfip8, Krt2-5, AW146334, 3300001P10Rik, Sak57, ckii, wu:fb02h09, wu:fj02d02, wu:fk78b12, zfCKII, KRT75
Reactivity
Human
(163), (63), (47), (30), (29), (27), (4), (3), (3), (2), (2), (1)
Host
Mouse
(104), (68), (4)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(9), (5), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
(119), (79), (79), (49), (27), (22), (20), (20), (17), (4), (3), (2), (1)
Pubmed 2 references available
Catalog no. ABIN969078
Quantity 100 µL
Price
429.00 $   Plus shipping costs $45.00
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Immunogen Purified recombinant fragment of CK5 expressed in E. coli.
Clone 3E2F1
Isotype IgG1
Purification Ascites
Alternative Name Cytokeratin 5
Background Synonyms:
K5, DDD, EBS2, KRT5A, KRT5
CK5 (keratin 5) is a member of the keratin gene family. Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells. Cytokeratin 5 is expressed in normal basal cells. Mutations of the Cytokeratin5 gene (KRT5) have been shown to result in the autosomal dominant disorderepidermolysis bullosa (EB). Defects in KRT5 are a cause of epidermolysis bullosa simplex.
Gene ID 3852
Research Area Signaling, Cytoskeleton, Cytokeratins, Extracellular Matrix
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
anti-Keratin 5 (KRT5) antibody Figure 3: Immunohistochemical analysis of paraffin-embedded human skin tissues using CK5 mouse mAb.
anti-Keratin 5 (KRT5) antibody (2) Figure 2: Immunohistochemical analysis of paraffin-embedded human esophagus epithelium (A), salivary gland basal cell (B), lung squamous cell carcinoma (C), endometrium admosquamous carcinoma (D), showing cytoplasmic and membrane localization using CK
anti-Keratin 5 (KRT5) antibody (3) Figure 1: Western blot analysis using CK5 mouse mAb against truncated CK5 recombinant protein
Product cited in: Canedo-Patzi, León-Bojorge, de Ortíz-Hidalgo: "[Adenomatoid tumor of the genital tract. Clinical, pathological and immunohistochemical study in 9 cases]." in: Gaceta médica de México, Vol. 142, Issue 1, pp. 59-66, 2006 (PubMed).

Leibl, Moinfar: "Mammary NOS-type sarcoma with CD10 expression: a rare entity with features of myoepithelial differentiation." in: The American journal of surgical pathology, Vol. 30, Issue 4, pp. 450-6, 2006 (PubMed).

Hosts (104), (68), (4)
Reactivities (163), (63), (47), (30), (29), (27), (4), (3), (3), (2), (2), (1)
Applications (119), (79), (79), (49), (27), (22), (20), (20), (17), (4), (3), (2), (1)
Conjugates (9), (5), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (23), (6), (2), (2), (2), (2), (2), (2), (1), (1)
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