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Details for Product No. ABIN969124

Fatty Acid Binding Protein 2, Intestinal (FABP2) antibody

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Antigen
Synonyms FABPI, I-FABP, FABP, Fabpi, IFABP, fabp2, fabp2a, ifabp, zgc:92264, fabpi, i-fabp, fabp2-A, FABP2
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Fluorescence Microscopy (FM)
Pubmed 4 references available
Catalog no. ABIN969124
Quantity 100 µL
Price
363.00 $   Plus shipping costs $45.00
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Immunogen Purified recombinant fragment of human FABP2 expressed in E. coli.
Clone 9A9B7B3
Isotype IgG1
Purification Ascites
Alternative Name FABP2
Background Synonyms:
FABPI, I-FABP, MGC133132, FABP2
The intracellular fatty acid-binding proteins (FABPs) belong to a multigene family with nearly twenty identified members. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular mηbolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Intestinal fatty acid-binding protein 2 gene contains four exons and is an abundant cytosolic protein in small intestine epithelial cells. This gene has a polymorphism at codon 54 that identified an alanine-encoding allele and a threonine-encoding allele. Thr-54 protein is associated with increased fat oxidation and insulin resistance. Genetic variation in FABP2 may thus contribute to interindividual variation in the response of plasma lipoproteins to different diηry fibres, but the mechanism does not appear to be related to increases in fecal bile acid secretion.
Molecular Weight 15 kDa
Gene ID 2169
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Product cited in: Yamada, Yuan, Ishiyama et al.: "Association between Ala54Thr substitution of the fatty acid-binding protein 2 gene with insulin resistance and intra-abdominal fat thickness in Japanese men." in: Diabetologia, Vol. 40, Issue 6, pp. 706-10, 1997 (PubMed).

Georgopoulos, Aras, Tsai: "Codon-54 polymorphism of the fatty acid-binding protein 2 gene is associated with elevation of fasting and postprandial triglyceride in type 2 diabetes." in: The Journal of clinical endocrinology and metabolism, Vol. 85, Issue 9, pp. 3155-60, 2000 (PubMed).

Kim, Yun, Byun et al.: "Codon 54 polymorphism of the fatty acid binding protein 2 gene is associated with increased fat oxidation and hyperinsulinemia, but not with intestinal fatty acid absorption in Korean men." in: Metabolism: clinical and experimental, Vol. 50, Issue 4, pp. 473-6, 2001 (PubMed).

Fisher, Li, Burwinkel et al.: "Preliminary evidence of FABP2 A54T polymorphism associated with reduced risk of type 2 diabetes and obesity in women from a German cohort." in: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme, Vol. 38, Issue 5, pp. 341-5, 2006 (PubMed).

Alternatives for antigen "Fatty Acid Binding Protein 2, Intestinal (FABP2)", type "Antibodies"
Hosts (66), (17), (15), (3)
Reactivities (86), (52), (51), (24), (17), (15), (2), (1)
Applications (47), (47), (30), (24), (23), (9), (8), (7), (6), (4), (3), (3), (2)
Conjugates (7), (5), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Epitopes (14), (8), (4), (2), (2), (1), (1)
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