GA Binding Protein Transcription Factor, alpha Subunit 60kDa (GABPA) (AA 120-190) antibody

Details for Product No. ABIN969163
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Antigen
Synonyms gabpa-A, XrpFI, X-alpha1, GABPA, nft2, nrf2, nrf2a, e4tf1a, e4tf1-60, Nrf-2alpha, Nrf2a, E4TF1-60, E4TF1A, NFT2, NRF2, NRF2A, RCH04A07, GABPalpha, e4tf, wu:fc12d11
Epitope
AA 120-190
(7), (5), (5), (5), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(61), (21), (13), (13), (13), (13), (12), (1), (1)
Host
Mouse
(32), (30)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB), Immunocytochemistry (ICC)
(50), (24), (24), (13), (10), (7), (2), (2), (2), (2), (2)
Pubmed 3 references available
Quantity 100 μL
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Catalog No. ABIN969163
363.00 $
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Immunogen Purified recombinant fragment of human GABPA (AA 120-190) expressed in E. coli.
Clone 8C1B10
Isotype IgG1
Purification Ascites
Alternative Name GABPA
Background Synonyms:
NFT2, NRF2
GABPA: GA binding protein transcription factor, α subunit 60 kDa. It is one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, it may play a role in the Down Syndrome phenotype.
Molecular Weight 51 kDa
Gene ID 2551
Research Area Chromatin and Nuclear Signaling, Transcription Factors
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, ICC: 1/200 - 1/1000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
anti-GA Binding Protein Transcription Factor, alpha Subunit 60kDa (GABPA) (AA 120-190) antibody Figure 3: Confocal immunofluorescence analysis of Hela cells using GABPA mouse mAb (green) . Red: Actin filaments have been labeled using DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye.
anti-GA Binding Protein Transcription Factor, alpha Subunit 60kDa (GABPA) (AA 120-190) antibody (2) Figure 1: Western blot analysis using GABPA mouse mAb against Hela (1), A549 (2), MCF-7 (3), NIH/3T3 (4) and SMMC-7721 (5) cell lysate.
anti-GA Binding Protein Transcription Factor, alpha Subunit 60kDa (GABPA) (AA 120-190) antibody (3) Figure 2: Western blot analysis using GABPA mouse mAb against HEK293T cells transfected with the pCMV6-ENTRY control (1) and pCMV6-ENTRY GABPA cDNA (2) .
Product cited in: Batchelor, Piper, de la Brousse et al.: "The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA." in: Science (New York, N.Y.), Vol. 279, Issue 5353, pp. 1037-41, 1998 (PubMed).

Sawada, Simizu, Suzuki et al.: "Synergistic transcriptional activation by hGABP and select members of the activation transcription factor/cAMP response element-binding protein family." in: The Journal of biological chemistry, Vol. 274, Issue 50, pp. 35475-82, 2000 (PubMed).

Vogel, Kristie: "The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP." in: The EMBO journal, Vol. 19, Issue 4, pp. 683-90, 2000 (PubMed).

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