anti-MBP antibody

Details for Product anti-MBP Antibody No. ABIN969279
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Synonyms Mbps, MBP, mMBP, mMBP-1
(128), (53), (47), (23), (8), (7), (6), (6), (5), (5), (3), (3), (2), (2), (1), (1), (1), (1)
(99), (51), (8), (2)
Clonality (Clone)
Monoclonal ()
This MBP antibody is un-conjugated
(6), (5), (5), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (1), (1)
ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunohistochemistry (IHC), Western Blotting (WB)
(92), (63), (30), (27), (19), (18), (9), (9), (8), (7), (7), (6), (4), (4), (2), (1)
Pubmed 2 references available
Quantity 100 μL
Shipping to United States ( )
Availability Will be delivered in 3 to 4 Business Days
Immunogen Purified recombinant fragment of human MBP expressed in E. coli.
Clone 2H9
Isotype IgG1
Purification Ascites
Background The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.
Molecular Weight 33 kDa
Gene ID 4155
HGNC 4155
Research Area Neurology
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
ELISA image for anti-MBP antibody (ABIN969279) Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 n...
Flow Cytometry (FACS) image for anti-MBP antibody (ABIN969279) Figure 2: Flow cytometric analysis of HepG2 cells using MBP mouse mAb (green) and neg...
Immunocytochemistry (ICC) image for anti-MBP antibody (ABIN969279) Figure 3: Immunofluorescence analysis of MSCS cells using MBP mouse mAb (green) . Blu...
Immunohistochemistry (IHC) image for anti-MBP antibody (ABIN969279) Figure 4: Immunohistochemical analysis of paraffin-embedded brain tissues using MBP m...
Immunohistochemistry (IHC) image for anti-MBP antibody (ABIN969279) Figure 5: Immunohistochemical analysis of paraffin-embedded cerebellum tissues using ...
Western Blotting (WB) image for anti-MBP antibody (ABIN969279) Figure 6: Western blot analysis using MBP mAb against human MBP (AA: 1-197) recombina...
Western Blotting (WB) image for anti-MBP antibody (ABIN969279) Figure 7: Western blot analysis using MBP mAb against HEK293 (1) and MBP-hIgGFc trans...
Product cited in: Rajaraman, Brenner, Butler et al.: "Common variation in genes related to innate immunity and risk of adult glioma." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 18, Issue 5, pp. 1651-8, 2009 (PubMed).

Hoos, Ahmed, Smith et al.: "Myelin basic protein binds to and inhibits the fibrillar assembly of Abeta42 in vitro." in: Biochemistry, Vol. 48, Issue 22, pp. 4720-7, 2009 (PubMed).

Catalog No. ABIN969279
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