Nuclear Receptor Co-Repressor 1 (NCOR1) (AA 1-192) antibody

Details for Product No. ABIN969310
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Antigen
Synonyms ncor, zgc:56355, 5730405M06Rik, A230020K14Rik, N-CoR, RIP13, Rxrip13, mKIAA1047, N-CoR1, TRAC1, hN-CoR
Epitope
AA 1-192
(15), (7), (6), (6), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(68), (34), (16), (2)
Host
Mouse
(56), (12), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
(55), (42), (36), (10), (10), (6), (3), (3), (1), (1), (1)
Pubmed 2 references available
Quantity 100 μL
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Catalog No. ABIN969310
407.00 $
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Immunogen Purified recombinant fragment of NCOR1 (AA 1-192) expressed in E. coli.
Clone 7A7A9
Isotype IgG1
Purification Ascites
Alternative Name NCOR1
Background Synonyms:
N-CoR, TRAC1, hN-CoR
NCOR1: Nuclear receptor co-repressor 1. This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. An alternatively spliced transcript variant has been described, but its full length sequence has not been determined.
Gene ID 9611
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
anti-Nuclear Receptor Co-Repressor 1 (NCOR1) (AA 1-192) antibody Figure 2: Immunohistochemical analysis of paraffin-embedded human cerebra (left) and breast carcinoma tissue (right), showing nuclear location with DAB staining using NCOR1 mouse mAb.
anti-Nuclear Receptor Co-Repressor 1 (NCOR1) (AA 1-192) antibody (2) Figure 1: Western blot analysis using NCOR1 mouse mAb against truncated Trx-NCOR1 recombinant protein (1) .
Product cited in: Zhang, Yoon, Wong: "JMJD2A is a novel N-CoR-interacting protein and is involved in repression of the human transcription factor achaete scute-like homologue 2 (ASCL2/Hash2)." in: Molecular and cellular biology, Vol. 25, Issue 15, pp. 6404-14, 2005 (PubMed).

Atsumi, Tomita, Kiyoi et al.: "Histone deacetylase 3 (HDAC3) is recruited to target promoters by PML-RARalpha as a component of the N-CoR co-repressor complex to repress transcription in vivo." in: Biochemical and biophysical research communications, Vol. 345, Issue 4, pp. 1471-80, 2006 (PubMed).

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