NCOR1 antibody (AA 51-100)

Catalog No. ABIN1533429

This Rabbit Polyclonal antibody specifically detects NCOR1 in ELISA, WB, IHC and IF. It exhibits reactivity toward Human and Mouse.

Quick Overview for NCOR1 antibody (AA 51-100) (ABIN1533429)

Target: NCOR1 (Nuclear Receptor Co-Repressor 1 (NCOR1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NCOR1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-NCOR1 Antibody

Binding Specificity: AA 51-100

Purpose: N-CoR Antibody

Specificity: N-CoR Polyclonal Antibody detects endogenous levels of N-CoR protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human NCoR1. AA range:51-100

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for NCOR1

Target: NCOR1 (Nuclear Receptor Co-Repressor 1 (NCOR1))

Alternative Name: NCoR1

Background:

Synonyms: NCOR1, KIAA1047, Nuclear receptor corepressor 1, N-CoR, N-CoR1

Background: This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010],

Gene Name: NCOR1

Protein Name: Nuclear receptor corepressor 1

Molecular Weight: 270 kDa

Gene ID: 9611

OMIM: 600849

UniProt: O75376

Pathways: Nuclear Hormone Receptor Binding, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha, Regulation of Carbohydrate Metabolic Process