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Cao, Szabolcs, Dutta, Yaqoob, Jagavelu, Wang, Leof, Urrutia, Shah, Mukhopadhyay: Neuropilin-1 mediates divergent R-Smad signaling and the myofibroblast phenotype. in The Journal of biological chemistry 2010
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Wang, Martin, Harris, Knudson: Caspase inhibition blocks cell death and enhances mitophagy but fails to promote T-cell lymphoma. in PLoS ONE 2011
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Zhu, Wang, Wang, Luo, Yang, Zhang, Yin, Xie, Pan, Chen: Hepatic deletion of Smad7 in mouse leads to spontaneous liver dysfunction and aggravates alcoholic liver injury. in PLoS ONE 2011
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Huang, Liu, Li, Zhang, Liu, Wu, Mao, Tang: HMGB1 Increases Permeability of the Endothelial Cell Monolayer via RAGE and Src Family Tyrosine Kinase Pathways. in Inflammation 2011
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Bassik, Scorrano, Oakes, Pozzan, Korsmeyer: Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis. in The EMBO journal 2004
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Lockshon, Surface, Kerr, Kaeberlein, Kennedy: The sensitivity of yeast mutants to oleic acid implicates the peroxisome and other processes in membrane function. in Genetics 2007
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Pérez-Andrés, Benito, Rodríguez-Fernández, Corradetti, Primo, Manzano, Orfao, Criado: Bisursodeoxycholate(ethylenediamine)platinum(II): a new autofluorescent compound. Cytotoxic activity and cell cycle analysis in ovarian and hematological cell lines. in Dalton transactions (Cambridge, England : 2003) 2008
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Maiseyeu, Mihai, Roy, Kherada, Simonetti, Sen, Sun, Parthasarathy, Rajagopalan: Detection of macrophages via paramagnetic vesicles incorporating oxidatively tailored cholesterol ester: an approach for atherosclerosis imaging. in Nanomedicine (London, England) 2010
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Boehm, Sen, Seethala, Gooding, Freilino, Wong, Wang, Johnson, Grandis: Combined targeting of epidermal growth factor receptor, signal transducer and activator of transcription-3, and Bcl-X(L) enhances antitumor effects in squamous cell carcinoma of the head and neck. in Molecular pharmacology 2008
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Tiwari, Messer, Mayeux: Inducible nitric oxide synthase and apoptosis in murine proximal tubule epithelial cells. in Toxicological sciences : an official journal of the Society of Toxicology 2006
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Results showed that ANXA5 rs1050606 was significantly associated with left ventricular hypertrophy in Chinese endogenous hypertension patients.
Moreover, mechanism study exhibited that Annexin A5 could activate PI3K (show PIK3CA ELISA Kits)/Akt (show AKT1 ELISA Kits)/mTOR (show FRAP1 ELISA Kits) signaling pathway, promote epithelial-mesenchymal transition (EMT (show ITK ELISA Kits)) and the expression of MMP2 (show MMP2 ELISA Kits) and MMP9 (show MMP9 ELISA Kits). Annexin A5 may be a potential prognostic biomarker in RCC (show XRCC1 ELISA Kits) and promotes proliferation, migration and invasion of RCC (show XRCC1 ELISA Kits) cells via activating PI3K (show PIK3CA ELISA Kits)/Akt (show AKT1 ELISA Kits)/mTOR (show FRAP1 ELISA Kits) signaling pathway and regulating EMT (show ITK ELISA Kits) process and MMP expression.
human myotubes rendered deficient for Annexin-A5 (AnxA5) suffer from a severe defect in membrane resealing.
This study functionally characterized allelic variants in the ANXA5 promoter, both alone and in combinations, and the results suggest that combinations of several individual variants contribute to modulate the ANXA5 transcriptional activity, most likely through binding of nuclear factors.
Chronically increased alveolar annexin V levels, as reflected in increased idiopathic pulmonary fibrosis (IPF) BALF levels, may contribute to the progression of IPF by inducing the release of pro-fibrotic mediators.
lower exhaled breath condensate annexin A5 levels in children with exercise-induced asthma compared to non-exercised-induced one
annexin A5 promoter haplotype M2 may not have a role in recurrent pregnancy loss in Estonia or Denmark
Annexin V is fused to an enzyme, creating a fusion protein that converts nontoxic drug precursors, prodrugs, into anticancer compounds while bound to the tumor, therefore mitigating the risk of side effects.
Neither the M1/M2 haplotypes nor the tag SNPs in ANXA5 were convincingly associated with pregnancy related venous thromboembolism.
Anx5 could protect cardiomyocytes adherens junctions and improve myocardial contractile function via regulation of p120 (show HNRNPU ELISA Kits) and anti-inflammation in LPS (show IRF6 ELISA Kits)-induced endotoxemia.
Anxa5 mediates the in vitro malignant behaviours of murine hepatocarcinoma Hca-F cells via ERK2 (show MAPK1 ELISA Kits)/c-Jun (show JUN ELISA Kits)/p-c-Jun (show JUN ELISA Kits)(Ser73) and ERK2 (show MAPK1 ELISA Kits)/E-cadherin (show CDH1 ELISA Kits) pathways.
findings suggest that GnRH (show GNRH1 ELISA Kits) is necessary for constitutive ANXA5 expression in the pituitary gland, not only in gonadotropes but also in other pituitary gland cell types
As a potential indicator for malignancy and lymphatic metastasis, ANXA5 overexpression increases in vitro migration and invasion of Hca-P cell, promotes in vivo malignancy, LNM rate and level of Hca-P-transplanted mice.
These data suggest that AnxA2 (show ANXA2 ELISA Kits) and AnxA5 can influence bone formation via regulation of osteoprogenitor proliferation, differentiation, and responsiveness to cytokines in addition to their well-studied function in matrix vesicles
annexin A5 may play a crucial role in cisplatin-induced toxicity by mediating the mitochondrial apoptotic pathway via the induction and oligomerization of VDAC.
The decrease of miR-1 and increase of AnxA5 appear as important modulators of NCX1 (show SLC8A1 ELISA Kits) expression and activity during heart failure.
double and opposite role of annexin A5 in regulating the endocytic and autophagic pathways and the fusion of autophagosomes with lysosomes and endosomes
Hence, the presence of maternal Anxa5 minimises the risk of thrombosis in the placental circulation and reduces the risk of foetal loss.
inhibited efferocytosis with annexin V worsened elastase-induced pulmonary emphysema in mice, which was, at least partly, attributed to a lack of phenotypic change in macrophages toward anti-inflammatory one.
AnxA5 participates in the membrane repair process.
The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. The gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa.
, annexin A5
, Annexin A5
, annexin A5-like
, anchorin CII
, annexin V
, calphobindin I
, endonexin II
, lipocortin V
, placental anticoagulant protein 4
, placental anticoagulant protein I
, thromboplastin inhibitor
, vascular anticoagulant-alpha
, Annexin V
, annexin V (endonexin II)