Browse our BIRC3 Proteins (BIRC3)

Full name:
Baculoviral IAP Repeat Containing 3 Proteins (BIRC3)
On are 8 Baculoviral IAP Repeat Containing 3 (BIRC3) Proteins from 6 different suppliers available. Additionally we are shipping BIRC3 Antibodies (161) and BIRC3 Kits (4) and many more products for this protein. A total of 190 BIRC3 products are currently listed.
AIP1, Api1, Api2, AW107670, AW146227, Birc2, Birc3, c-IAP2, cIAP-1, cIAP-2, cIAP1, cIAP2, HAIP1, HIAP1, HIAP2, IAP1, IAP2, MALT2, mcIAP1, MIAP1, MIAP2, MIHB, MIHC, rIAP1, RNF48, RNF49
list all proteins Gene Name GeneID UniProt
BIRC3 330 Q13489
BIRC3 11797 Q62210
BIRC3 60371  

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BIRC3 Proteins (BIRC3) by Origin

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Human Baculoviral IAP Repeat Containing 3 (BIRC3) interaction partners

  1. destabilization of TRAF2 (show TRAF2 Proteins) by miR-17 reduced the ability of TRAF2 (show TRAF2 Proteins) to associate with cIAP2, resulting in the downregulation of TNF-alpha (show TNF Proteins)-induced NF-kappaBp65, c-Jun (show JUN Proteins), and STAT3 (show STAT3 Proteins) nuclear translocation and the production of IL-6 (show IL6 Proteins), IL-8 (show IL8 Proteins), MMP-1 (show MMP1 Proteins), and MMP-13 (show MMP13 Proteins) in human rheumatoid arthritis synovial fibroblasts.

  2. The expression of cIAP2 mRNA was significantly higher in the groups with Helicobacter pylori(+), atrophic gastritis/intestinal metaplasia(+), and Helicobacter pylori-positive early gastric cancer than in the control, Helicobacter pylori(+), and atrophic gastritis/intestinal metaplasia(-) groups.

  3. Polymorphisms in the BIRC3 gene are associated with a protective effect with regards to asthma susceptibility, and a reduced load of inflammatory cells.

  4. we indicated that miR (show MLXIP Proteins)-34a can inhibit tumor invasion and metastasis in osteosarcoma, and its mechanism may be partly related to downregulating the expression of C-IAP2 and Bcl-2 (show BCL2 Proteins) protein directly or indirectly.

  5. Study demonstrate that BIRC3 expression increases secondary to acquisition of temozolomide TMZ and irradiation resistance in glioblastoma.

  6. High BIRC3 expression is associated with pancreatic cancer.

  7. Network analysis identified BIRC3 as pathogenic gene in childhood asthma.

  8. The clinical impact of small subclones harboring NOTCH1 (show NOTCH1 Proteins), SF3B1 (show SF3B2 Proteins), or BIRC3 mutations in chronic lymphocytic leukemia patients appears to be less pronounced than that of small TP53 (show TP53 Proteins) mutated subclones.

  9. cIAP1 (show BIRC2 Proteins) and cIAP2 mediate BCL10 (show BCL10 Proteins) ubiquitination essential for BCR (show BCR Proteins)-dependent NF-kB activity in the ABC (show ABCB6 Proteins) subtype of DLBCL. cIAP1 (show BIRC2 Proteins)/2 attach K63-linked polyubiquitin (show UBB Proteins) chains on themselves and on BCL10 (show BCL10 Proteins), recruiting IKK (show CHUK Proteins) and LUBAC essential for IKK (show CHUK Proteins) activation.

  10. Data indicate that Smac/DIABLO (show DIABLO Proteins) showed an inverse correlation with inhibitor of apoptosis proteins XIAP (show XIAP Proteins), cIAP-1 (show BIRC2 Proteins) and cIAP-2.

Mouse (Murine) Baculoviral IAP Repeat Containing 3 (BIRC3) interaction partners

  1. These findings reveal a novel mechanism that endotoxin tolerance reprograms mitogen-activated protein kinase (show MAPK1 Proteins) signaling by suppressing Pellino 1 (show PELI1 Proteins)-mediated K63-linked ubiquitination of cIAP2, K48-linked ubiquitination, and degradation of TRAF3 (show TRAF3 Proteins).

  2. Birc3-deficient mice are resistant to azoxymethane-sodium dodecyl sulfate-induced colitis-associated colorectal cancer.

  3. c-IAP (show ALPI Proteins) ubiquitin protein ligase (show UBE2K Proteins) activity is required for 4-1BB (show TNFRSF9 Proteins) signaling and CD8 (show CD8A Proteins)(+) memory T-cell survival.

  4. Induction of cIAP2 expression upon microglia activation prevents the conversion of caspase-3 p19 subunit to p17 subunit.

  5. Results identify IGF2BP1 (show B4GALNT2 Proteins) as a critical translational regulator of cIAP1 (show BIRC2 Proteins)-mediated apoptotic resistance in rhabdomyosarcoma.

  6. we show that cIAP1 (show BIRC2 Proteins) regulates TNF (show TNF Proteins)-induced actin cytoskeleton reorganization through a cdc42 (show CDC42 Proteins)-dependentpathway

  7. Identify xIAP (show XIAP Proteins) and cIAP1 (show BIRC2 Proteins) as molecular targets of ceramide and show ceramide analog LCL85 is an effective sensitizer in overcoming resistance of metastatic colon and breast cancers to apoptosis induction to suppress metastasis in vivo.

  8. cIAP2 (Birc3)-dependent antagonism of RIPK3 (show RIPK3 Proteins)-mediated programmed necrosis critically protects the host from influenza infection through maintenance of pulmonary tissue homeostasis.

  9. cIAP-2 protects cardiac fibroblasts from oxidative damage: an obligate regulatory role for ERK1/2 MAPK (show MAPK1 Proteins) and NF-kappaB (show NFKB1 Proteins).

  10. these results show that the loss of cIAP1 (show BIRC2 Proteins) protects skeletal muscle from the degenerative pathology resulting from systemic loss of dystrophin (show DMD Proteins).

BIRC3 Protein Profile

Protein Summary

This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified.

Alternative names and synonyms associated with BIRC3

  • baculoviral IAP repeat-containing 3 (BIRC3)
  • inhibitor of apoptosis protein-2 (OpmnVgp074)
  • baculoviral IAP repeat containing 3 (BIRC3)
  • baculoviral IAP repeat-containing 2 (Birc2)
  • baculoviral IAP repeat-containing 3 (Birc3)
  • AIP1 protein
  • Api1 protein
  • Api2 protein
  • AW107670 protein
  • AW146227 protein
  • Birc2 protein
  • Birc3 protein
  • c-IAP2 protein
  • cIAP-1 protein
  • cIAP-2 protein
  • cIAP1 protein
  • cIAP2 protein
  • HAIP1 protein
  • HIAP1 protein
  • HIAP2 protein
  • IAP1 protein
  • IAP2 protein
  • MALT2 protein
  • mcIAP1 protein
  • MIAP1 protein
  • MIAP2 protein
  • MIHB protein
  • MIHC protein
  • rIAP1 protein
  • RNF48 protein
  • RNF49 protein

Protein level used designations for BIRC3

baculoviral IAP repeat-containing 3 , baculoviral IAP repeat-containing protein 3-like , inhibitor of apoptosis protein-2 , IAP homolog C , IAP-1 , RING finger protein 49 , TNFR2-TRAF signaling complex protein , TNFR2-TRAF-signaling complex protein 1 , apoptosis inhibitor 2 , baculoviral IAP repeat-containing protein 3 , inhibitor of apoptosis protein 1 , mammalian IAP homolog C , IAP-2 , baculoviral IAP repeat-containing protein 2 , inhibitor of apoptosis protein 2 , mIAP-2 , inhibitor of apoptosis protein , apoptosis inhibitor 1 , baculoviral IAP repeat-containing 2 , mIAP-1

100399118 Callithrix jacchus
912069 Orgyia pseudotsugata multiple nucleopolyhedrovirus
330 Homo sapiens
489433 Canis lupus familiaris
11797 Mus musculus
60371 Rattus norvegicus
11796 Mus musculus
78971 Rattus norvegicus
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