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Browse our Caspase 1 Proteins (CASP1)

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Caspase 1 Proteins (CASP1)
On are 31 Caspase 1 (CASP1) Proteins from 10 different suppliers available. Additionally we are shipping Caspase 1 Antibodies (283) and Caspase 1 Kits (45) and many more products for this protein. A total of 379 Caspase 1 products are currently listed.
CASP1, ccp1, CG5370, dcp-1, dcp1, Dmel\\CG5370, ICE, IL1BC, l(2)01862, l(2)02132, P45
list all proteins Gene Name GeneID UniProt
CASP1 12362 P29452
CASP1 25166  
CASP1 834 P29466

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Caspase 1 Proteins (CASP1) by Origin

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Top referenced Caspase 1 Proteins

  1. Human Caspase 1 Protein expressed in Escherichia coli (E. coli) - ABIN2487270 : Chen, Xia, Fang, Hawke, Lu: Caspase-10-mediated heat shock protein 90 beta cleavage promotes UVB irradiation-induced cell apoptosis. in Molecular and cellular biology 2009 (PubMed)
    Show all 8 references for ABIN2487270

  2. Mouse (Murine) Caspase 1 Protein expressed in Escherichia coli (E. coli) - ABIN2487280 : Newman, Leppla, Moayeri: CA-074Me protection against anthrax lethal toxin. in Infection and immunity 2009 (PubMed)
    Show all 4 references for ABIN2487280

  3. Human Caspase 1 Protein expressed in Escherichia coli (E. coli) - ABIN1046768 : Thornberry, Bull, Calaycay, Chapman, Howard, Kostura, Miller, Molineaux, Weidner, Aunins: A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. in Nature 1992 (PubMed)
    Show all 3 references for ABIN1046768

More Proteins for Caspase 1 Interaction Partners

Fruit Fly (Drosophila melanogaster) Caspase 1 (CASP1) interaction partners

  1. drICE (show CASP3 Proteins) and dcp-1 (show ACE Proteins) function in cell death redundantly. However, dying neurons in a few clusters strictly required drICE (show CASP3 Proteins) but not dcp-1 (show ACE Proteins), but required drICE (show CASP3 Proteins) and dcp-1 (show ACE Proteins) when drICE (show CASP3 Proteins) activity was reduced via hypomorphic mutation.

  2. Drosophila corazonin-producing interneuron programmed cell death utilizes dronc, strica, dcp-1 (show ACE Proteins), and ice

  3. Autophagy suppresses Dcp-1 (show ACE Proteins)-mediated apoptotic cell death, whereas Dcp-1 (show ACE Proteins) positively regulates autophagy, possibly through feedback regulation.

  4. novel characteristic morphological features of egg chambers lacking both dcp-1 (show ACE Proteins) and pita functions in the germline cells; suggested an essential role of dcp-1 (show ACE Proteins) and/or pita during mid-oogenesis

  5. A double-mutant analysis between drICE (show CASP3 Proteins) and death caspase-1 (dcp-1), another effector caspase (show CASP3 Proteins), reveals that some cells (type I) strictly require drICE (show CASP3 Proteins) for apoptosis, whereas other cells (type II) require either drICE (show CASP3 Proteins) or dcp-1 (show ACE Proteins).

  6. Data show that the effector caspase Dcp-1 and the inhibitor of apoptosis protein Bruce function to regulate both autophagy and starvation-induced cell death in Drosophila.

  7. HeT-A mRNA is derepressed in mRNA degradation mutants dcp1 (show ACE Proteins), indicating that the enzyme also aid in removing full-length transcripts and/or decay intermediates.

Silk Worm Caspase 1 (CASP1) interaction partners

  1. Activation of Atg5 (show ATG5 Proteins), AIF (show AIFM1 Proteins) and caspase (show CASP3 Proteins) genes in close association with different cell death events revealed the synchronized differential expression of apoptosis-associated genes in response to macroparasitism.

Mouse (Murine) Caspase 1 (CASP1) interaction partners

  1. Chronic kidney disease-mediated increase of contractile markers in vascular smooth muscle cells and increased expression of VSMC migration molecule alphavbeta3 integrin in NH formation were caspase-1 dependent.

  2. Demonstrate the utility of intracellular caspase 1 and extracellular CTSS (show CTSS Proteins) proteolytic activities as surrogate biomarkers of lysosomal rupture and acute inflammation.

  3. Caspase-11 (show CASP4 Proteins) targets cofilin (show CFL1 Proteins) via the RhoA GTPase, whereas caspase-1 engages the Slingshot phosphatase

  4. Caspase-1-/- mice have intact immune responses but do not develop an expanded marginal zone B cell population in response to pristane-induced lupus. This may be one explanation for reduced IgG autoantibody production in these mice.

  5. study uncovered an important role for YopJ in inhibiting caspase-1 in activated macrophages and in promoting Yersinia virulence

  6. Caspase-1-activated IL-18 (show IL18 Proteins) induces IFN-gamma (show IFNG Proteins) to prime caspase-11 (show CASP4 Proteins) and rapidly clear Burkholderia thailandensis infection.

  7. These results argue that caspase-1, -4 or -5 can be recruited to inflammasomes under specific circumstances, often leading to distinctly organized and localized complexes that may impact the functions of these proteases

  8. The resilience of casp1(-/-) mice to SIRS lethality is associated with a lower inflammatory response, loss of hippocampal gene coexpression patterns, and increased hippocampal Adamts1 (show ADAMTS1 Proteins) gene expression.

  9. Internalized Cryptococcus neoformans Activates the Canonical Caspase-1 and the Noncanonical Caspase-8 (show CASP8 Proteins) Inflammasomes.

  10. This study highlights a critical role of caspase-1 activation and NLPR3/ASC (show STS Proteins) inflammasome complex in the down-modulation of IL-33 (show IL33 Proteins) in vivo and in vitro.

Human Caspase 1 (CASP1) interaction partners

  1. High expression of NLRP3 (show NLRP3 Proteins), NLRC4 (show NLRC4 Proteins), and CASP1 in background non-tumorous liver is significantly correlated with poor prognosis of patients after resection of hepatocellular carcinoma.

  2. The proteins of NLRP3 (show NLRP3 Proteins), ASC (show PYCARD Proteins), and caspase-1 were observed in infiltrating inflammatory cells in cholesteatoma and chronic otitis media.

  3. The results indicate that acteoside may act as a regulator of the IL-32 (show IL32 Proteins) induced immune responses.

  4. These results suggest that released caspase-1 exists in a unique complex that is functionally stable and protected from immunodepletion whereas cell-extract generated active caspase-1 is rapidly inhibited in the cytosolic milieu.

  5. Genetic polymorphisms in Nalp3 (show NLRP3 Proteins) and caspase-1 may be associated with individual susceptibility to silicosis, especially when the polymorphisms interact with age, cumulative dust exposure, or smoking status.

  6. In contrast, inhibition of the protease activity of Kgp, RgpA or RgpB increased the human caspase-1-activating potential of wild-type Porphyromonas gingivalis, indicating an inhibitory effect of the collaborative action of gingipains.

  7. NLRP3 (show NLRP3 Proteins) and caspase-1 are expressed in the odontoblast layers in normal human dental pulp tissue, whereas in inflamed pulp tissue, the odontoblast layers are disrupted and dental pulp cells are positive for NLRP3 (show NLRP3 Proteins) and caspase-1.

  8. the rs713875 IBD risk polymorphism increases MTMR3 (show MTMR3 Proteins) expression, which modulates pattern recognition receptor (PRR (show PVRL1 Proteins))-induced outcomes, including increased induced caspase-1 activation

  9. specific caspase (show CASP3 Proteins) cleavage sites in Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen function to blunt apoptosis as well as interfere with the caspase-1-mediated inflammasome

  10. three cofactor independent human monoclonal aPL (show FASL Proteins) can induce transcription of NLRP3 (show NLRP3 Proteins) and caspase-1 resulting in inflammasome activation specific for NLRP3 (show NLRP3 Proteins), which depends fully on activation of endosomal NADPH-oxidase-2 (NOX2 (show CYBB Proteins)) by aPL (show FASL Proteins)

Pig (Porcine) Caspase 1 (CASP1) interaction partners

  1. Src kinase (show CSK Proteins) mediates hypoxia-induced caspase-1 activation in the cerebral cortex of newborn piglets

  2. endometrial expression of CASP1 and IL18 (show IL18 Proteins) associated with pregnancy establishment; alteration of CASP1 and IL18 (show IL18 Proteins) following premature exposure of uterus to estrogen during early pregnancy may contribute to conceptus loss between Days 15 to 18 of pregnancy

Caspase 1 (CASP1) Protein Profile

Protein Summary

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.

Alternative names and synonyms associated with Caspase 1 (CASP1)

  • Death caspase-1 (Dcp-1)
  • caspase-1 (Ice)
  • caspase-1 (AaeL_AAEL014348)
  • caspase 1 (Casp1)
  • caspase 1 (LOC100101588)
  • caspase 1, apoptosis-related cysteine peptidase (CASP1)
  • caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) (CASP1)
  • caspase 4, apoptosis-related cysteine peptidase (CASP4)
  • caspase-1-like (LOC100725217)
  • CASP1 protein
  • ccp1 protein
  • CG5370 protein
  • dcp-1 protein
  • dcp1 protein
  • Dmel\\CG5370 protein
  • ICE protein
  • IL1BC protein
  • l(2)01862 protein
  • l(2)02132 protein
  • P45 protein

Protein level used designations for Caspase 1 Proteins (CASP1)

CG5370-PA , Dcp-1-PA , caspase , caspase 1 , caspase-1 , death caspase-1 , CASP-1 , IL-1 beta-converting enzyme , IL-1B converting enzyme , IL-1BC , interleukin 1 beta-converting enzyme , interleukin-1 beta convertase , interleukin-1 beta-converting enzyme , p45 , Interleukin 1beta converting enzyme , interleukin 1, beta, convertase , CASP1 nirs variant 1 , IL1B-convertase , caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) , interleukin 1-B converting enzyme , ICE , interleukin-1 beta converting enzyme , caspase-1/caspase-4 hybrid , caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase)

37729 Drosophila melanogaster
692604 Bombyx mori
5564196 Aedes aegypti
12362 Mus musculus
25166 Rattus norvegicus
100101588 Oryctolagus cuniculus
834 Homo sapiens
397319 Sus scrofa
493961 Felis catus
100033888 Equus caballus
395764 Gallus gallus
514214 Bos taurus
403724 Canis lupus familiaris
100725217 Cavia porcellus
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