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Human Caspase 1 Protein expressed in Escherichia coli (E. coli) - ABIN2487270
Chen, Xia, Fang, Hawke, Lu: Caspase-10-mediated heat shock protein 90 beta cleavage promotes UVB irradiation-induced cell apoptosis. in Molecular and cellular biology 2009
Show all 8 Pubmed References
Mouse (Murine) Caspase 1 Protein expressed in Escherichia coli (E. coli) - ABIN2487280
Newman, Leppla, Moayeri: CA-074Me protection against anthrax lethal toxin. in Infection and immunity 2009
Show all 4 Pubmed References
besides its role in the inhibition of the NF-kappaB (show NFKB1 Proteins) pathway, NLRC3 interferes with the assembly and activity of the NALP3 (show NLRP3 Proteins) inflammasome complex by competing with ASC (show PYCARD Proteins) for pro-caspase-1 binding
Data, including data from studies using recombinant fusion forms of GSDMD (gasdermin D (show GSDMD Proteins)), suggest that GSDMD (show GSDMD Proteins) participates in inflammasome-dependent pyroptosis of macrophages in response to various stimuli; this mechanism involves proteolysis of GSDMD (show GSDMD Proteins) by caspase-1 and caspase-11 (show CASP4 Proteins).
Proteases caspase-1 and caspase-8 (show CASP8 Proteins) have redundant roles in cleaving IL-1beta (show IL1B Proteins) and promoting osteomyelitis. [review]
Patients with NLRP1-associated autoinflammation with arthritis and dyskeratosis syndrome had increased systemic CASP1.
The biochemical function of NLPR3 inflammasomes is to activate caspase-1, which leads to the maturation of interleukin 1 beta (show IL1B Proteins) and IL-18 (show IL18 Proteins) and the induction of pyroptosis, a form of cell death. (Review)
The structure of the human caspase-1 CARD domain (caspase-1(CARD)) filament solved by cryo-electron microscopy.
Caspase-1-mediated downregulation of PPARgamma (show PPARG Proteins) was important in the late stage of monocyte-macrophage differentiation; however, PPARgamma (show PPARG Proteins) protein levels had little effect on the early stage differentiation.
Inflammasome NLRP3 (show NLRP3 Proteins)-caspase-1-mediated degradation of smooth muscle cell contractile proteins may contribute to aortic biomechanical dysfunction and aortic aneurysm/dissection development.
Study demonstrates that the expression of the NLRP3 (show NLRP3 Proteins)-caspase-1-IL-18 (show IL18 Proteins) axis is highly expressed in the peripheral blood mononuclear cells of patients with bullous pemphigoid (show DST Proteins) (BP), and correlated with disease activity, suggesting its involvement in the pathogenesis and progression of BP.
High expression of CASP1 is associated with osteosarcoma.
Hemorrhagic shock primes for lung vascular endothelial cell pyroptosis following lipopolysaccharide exposure through TLR4 (show TLR4 Proteins), which activates Nlrp3 (show NLRP3 Proteins), and subsequently induces caspase-1 activation.
The most well-known function of active caspase-1 is to cleave the proforms of inflammatory cytokines IL-1beta (show IL1B Proteins) and -18 into their active forms in response to inflammatory stimuli in immune cells. Caspase-1 has multiple functions in addition to this cytokine maturation role. It is at the center of many cell responses to stress and inflammation not just in immune cells but in other cell types, such as epithelia. Review.
Findings demonstrate a critical role of caspase-1 in macrophage-driven inflammation in the adipose tissue and the development of obesity.
Data indicate that NLRC4 (show NLRC4 Proteins) activation in Intestinal epithelial cells (IECs) leads to cell expulsion and IL-18 (show IL18 Proteins) release, and implicate Caspase-8 (show CASP8 Proteins) in NLRC4 (show NLRC4 Proteins) inflammasome responses in vivo by generation of doubly deficient in Caspase-1 and Caspase-8 (show CASP8 Proteins).
our studies have uncovered a specific role for caspase-1-mediated IL-1beta (show IL1B Proteins) release in the manifestation of Familial Mediterranean Fever (show MEFV Proteins)
variant p.C284A caspase-1 stabilizes pyroptosome formation, potentially enhancing inflammation by two IL-1beta-independent mechanisms: pyroptosomes convey an enhanced inflammatory stimulus through the recruitment of additional proteins (such as RIP2, receptor interacting protein kinase 2), which is further amplified through pyroptosome and cell division.
TNF-alpha (show TNF Proteins) induces caspase-1 activation in an inflammasome-independent manner in 3T3-L1 cells and that the ERK (show EPHB2 Proteins)-dependent expression of NLRP3 (show NLRP3 Proteins) may play a role independently of its canonical role as a component of inflammasomes.
caspase-1 activation is an upstream event of apoptotic caspase-7 (show CASP7 Proteins) induction in renal tubulointerstitial fibrosis
it was found that GSK2656157 specifically inhibited ER stress induced by large amount of LPS (show TLR4 Proteins) and reduced LPS (show TLR4 Proteins)-induced IL-1beta (show IL1B Proteins) production through inhibition of Caspase 1 activation.
Src kinase (show CSK Proteins) mediates hypoxia-induced caspase-1 activation in the cerebral cortex of newborn piglets
endometrial expression of CASP1 and IL18 (show IL18 Proteins) associated with pregnancy establishment; alteration of CASP1 and IL18 (show IL18 Proteins) following premature exposure of uterus to estrogen during early pregnancy may contribute to conceptus loss between Days 15 to 18 of pregnancy
drICE (show CASP3 Proteins) and dcp-1 (show ACE Proteins) function in cell death redundantly. However, dying neurons in a few clusters strictly required drICE (show CASP3 Proteins) but not dcp-1 (show ACE Proteins), but required drICE (show CASP3 Proteins) and dcp-1 (show ACE Proteins) when drICE (show CASP3 Proteins) activity was reduced via hypomorphic mutation.
Drosophila corazonin-producing interneuron programmed cell death utilizes dronc, strica, dcp-1 (show ACE Proteins), and ice
Autophagy suppresses Dcp-1 (show ACE Proteins)-mediated apoptotic cell death, whereas Dcp-1 (show ACE Proteins) positively regulates autophagy, possibly through feedback regulation.
novel characteristic morphological features of egg chambers lacking both dcp-1 (show ACE Proteins) and pita functions in the germline cells; suggested an essential role of dcp-1 (show ACE Proteins) and/or pita during mid-oogenesis
A double-mutant analysis between drICE (show CASP3 Proteins) and death caspase-1 (dcp-1), another effector caspase (show CASP3 Proteins), reveals that some cells (type I) strictly require drICE (show CASP3 Proteins) for apoptosis, whereas other cells (type II) require either drICE (show CASP3 Proteins) or dcp-1 (show ACE Proteins).
Data show that the effector caspase Dcp-1 and the inhibitor of apoptosis protein Bruce function to regulate both autophagy and starvation-induced cell death in Drosophila.
HeT-A mRNA is derepressed in mRNA degradation mutants dcp1 (show ACE Proteins), indicating that the enzyme also aid in removing full-length transcripts and/or decay intermediates.
cBm-IAP1 (show BIRC3 Proteins) is a vital negative regulator of apoptosis in BM-N cells and functions by preventing the activation and/or activity of Bm-Dronc and Bm-caspase-1.
Activation of Atg5 (show ATG5 Proteins), AIF (show AIFM1 Proteins) and caspase (show CASP3 Proteins) genes in close association with different cell death events revealed the synchronized differential expression of apoptosis-associated genes in response to macroparasitism.
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.
CASP1 nirs variant 1
, IL-1 beta-converting enzyme
, caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
, interleukin 1, beta, convertase
, interleukin 1-B converting enzyme
, IL-1B converting enzyme
, interleukin 1 beta-converting enzyme
, interleukin-1 beta convertase
, interleukin-1 beta-converting enzyme
, Interleukin 1beta converting enzyme
, caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase)
, interleukin-1 beta converting enzyme
, caspase-1/caspase-4 hybrid
, caspase 1
, death caspase-1