Browse our Caspase 1 Proteins (CASP1)

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Caspase 1 Proteins (CASP1)
On are 33 Caspase 1 (CASP1) Proteins from 9 different suppliers available. Additionally we are shipping Caspase 1 Antibodies (272) and Caspase 1 Kits (53) and many more products for this protein. A total of 379 Caspase 1 products are currently listed.
CASP1, ccp1, CG5370, dcp-1, dcp1, Dmel\\CG5370, ICE, IL1BC, l(2)01862, l(2)02132, P45
list all proteins Gene Name GeneID UniProt
CASP1 12362 P29452
CASP1 25166  
CASP1 834 P29466

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Caspase 1 Proteins (CASP1) by Origin

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Top referenced Caspase 1 Proteins

  1. Human Caspase 1 Protein expressed in Escherichia coli (E. coli) - ABIN2487270 : Chen, Xia, Fang, Hawke, Lu: Caspase-10-mediated heat shock protein 90 beta cleavage promotes UVB irradiation-induced cell apoptosis. in Molecular and cellular biology 2009 (PubMed)
    Show all 8 references for 2487270

  2. Mouse (Murine) Caspase 1 Protein expressed in Escherichia coli (E. coli) - ABIN2487280 : Newman, Leppla, Moayeri: CA-074Me protection against anthrax lethal toxin. in Infection and immunity 2009 (PubMed)
    Show all 4 references for 2487280

  3. Human Caspase 1 Protein expressed in Escherichia coli (E. coli) - ABIN1046768 : Thornberry, Bull, Calaycay, Chapman, Howard, Kostura, Miller, Molineaux, Weidner, Aunins: A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. in Nature 1992 (PubMed)
    Show all 3 references for 1046768

More Proteins for Caspase 1 Interaction Partners

Fruit Fly (Drosophila melanogaster) Caspase 1 (CASP1) interaction partners

  1. drICE (show CASP3 Proteins) and dcp-1 (show ACE Proteins) function in cell death redundantly. However, dying neurons in a few clusters strictly required drICE (show CASP3 Proteins) but not dcp-1 (show ACE Proteins), but required drICE (show CASP3 Proteins) and dcp-1 (show ACE Proteins) when drICE (show CASP3 Proteins) activity was reduced via hypomorphic mutation.

  2. Drosophila corazonin-producing interneuron programmed cell death utilizes dronc, strica, dcp-1 (show ACE Proteins), and ice

  3. Autophagy suppresses Dcp-1 (show ACE Proteins)-mediated apoptotic cell death, whereas Dcp-1 (show ACE Proteins) positively regulates autophagy, possibly through feedback regulation.

  4. novel characteristic morphological features of egg chambers lacking both dcp-1 (show ACE Proteins) and pita functions in the germline cells; suggested an essential role of dcp-1 (show ACE Proteins) and/or pita during mid-oogenesis

  5. A double-mutant analysis between drICE (show CASP3 Proteins) and death caspase-1 (dcp-1), another effector caspase (show CASP3 Proteins), reveals that some cells (type I) strictly require drICE (show CASP3 Proteins) for apoptosis, whereas other cells (type II) require either drICE (show CASP3 Proteins) or dcp-1 (show ACE Proteins).

  6. Data show that the effector caspase Dcp-1 and the inhibitor of apoptosis protein Bruce function to regulate both autophagy and starvation-induced cell death in Drosophila.

  7. HeT-A mRNA is derepressed in mRNA degradation mutants dcp1 (show ACE Proteins), indicating that the enzyme also aid in removing full-length transcripts and/or decay intermediates.

Silk Worm Caspase 1 (CASP1) interaction partners

  1. Activation of Atg5 (show ATG5 Proteins), AIF (show AIFM1 Proteins) and caspase (show CASP3 Proteins) genes in close association with different cell death events revealed the synchronized differential expression of apoptosis-associated genes in response to macroparasitism.

Mouse (Murine) Caspase 1 (CASP1) interaction partners

  1. Findings demonstrate a critical role of caspase-1 in macrophage-driven inflammation in the adipose tissue and the development of obesity.

  2. Inflammasome NLRP3 (show NLRP3 Proteins)-caspase-1-mediated degradation of smooth muscle cell contractile proteins may contribute to aortic biomechanical dysfunction and aortic aneurysm/dissection development.

  3. Data indicate that NLRC4 (show NLRC4 Proteins) activation in Intestinal epithelial cells (IECs) leads to cell expulsion and IL-18 (show IL18 Proteins) release, and implicate Caspase-8 (show CASP8 Proteins) in NLRC4 (show NLRC4 Proteins) inflammasome responses in vivo by generation of doubly deficient in Caspase-1 and Caspase-8 (show CASP8 Proteins).

  4. our studies have uncovered a specific role for caspase-1-mediated IL-1beta (show IL1B Proteins) release in the manifestation of Familial Mediterranean Fever (show MEFV Proteins)

  5. variant p.C284A caspase-1 stabilizes pyroptosome formation, potentially enhancing inflammation by two IL-1beta-independent mechanisms: pyroptosomes convey an enhanced inflammatory stimulus through the recruitment of additional proteins (such as RIP2, receptor interacting protein kinase 2), which is further amplified through pyroptosome and cell division.

  6. TNF-alpha (show TNF Proteins) induces caspase-1 activation in an inflammasome-independent manner in 3T3-L1 cells and that the ERK (show EPHB2 Proteins)-dependent expression of NLRP3 (show NLRP3 Proteins) may play a role independently of its canonical role as a component of inflammasomes.

  7. caspase-1 activation is an upstream event of apoptotic caspase-7 (show CASP7 Proteins) induction in renal tubulointerstitial fibrosis

  8. it was found that GSK2656157 specifically inhibited ER stress induced by large amount of LPS (show TLR4 Proteins) and reduced LPS (show TLR4 Proteins)-induced IL-1beta (show IL1B Proteins) production through inhibition of Caspase 1 activation.

  9. Study suggests that Casp1 has a limited role in the development of burn-induced pain.

  10. Data show that inhibiting caspase-1 activity in the NLR (show CXCR5 Proteins) family, pyrin domain-containing 3 protein (NLRP3 (show NLRP3 Proteins)) inflammasome decreased gastric cell apoptosis.

Human Caspase 1 (CASP1) interaction partners

  1. Proteases caspase-1 and caspase-8 (show CASP8 Proteins) have redundant roles in cleaving IL-1beta (show IL1B Proteins) and promoting osteomyelitis. [review]

  2. Patients with NLRP1-associated autoinflammation with arthritis and dyskeratosis syndrome had increased systemic CASP1.

  3. The biochemical function of NLPR3 inflammasomes is to activate caspase-1, which leads to the maturation of interleukin 1 beta (show IL1B Proteins) and IL-18 (show IL18 Proteins) and the induction of pyroptosis, a form of cell death. (Review)

  4. The structure of the human caspase-1 CARD domain (caspase-1(CARD)) filament solved by cryo-electron microscopy.

  5. Caspase-1-mediated downregulation of PPARgamma (show PPARG Proteins) was important in the late stage of monocyte-macrophage differentiation; however, PPARgamma (show PPARG Proteins) protein levels had little effect on the early stage differentiation.

  6. Inflammasome NLRP3 (show NLRP3 Proteins)-caspase-1-mediated degradation of smooth muscle cell contractile proteins may contribute to aortic biomechanical dysfunction and aortic aneurysm/dissection development.

  7. Study demonstrates that the expression of the NLRP3 (show NLRP3 Proteins)-caspase-1-IL-18 (show IL18 Proteins) axis is highly expressed in the peripheral blood mononuclear cells of patients with bullous pemphigoid (show DST Proteins) (BP), and correlated with disease activity, suggesting its involvement in the pathogenesis and progression of BP.

  8. High expression of CASP1 is associated with osteosarcoma.

  9. This study demonstrated that dysregulated expression of NLRP3 (show NLRP3 Proteins)-caspase-1-IL-1beta (show IL1B Proteins) axis was observed in patients with MM, suggesting they might be involved in the pathogenesis of MM.

  10. The NLRP3 (show NLRP3 Proteins)/caspase-1/IL-1beta (show IL1B Proteins) axis is active in cartilaginous endplates of patients with Modic changes and inflammatory cascades can exacerbate the cartilaginous endplate degeneration which may act as a trigger for intervertebral disc degeneration and low back pain.

Pig (Porcine) Caspase 1 (CASP1) interaction partners

  1. Src kinase (show CSK Proteins) mediates hypoxia-induced caspase-1 activation in the cerebral cortex of newborn piglets

  2. endometrial expression of CASP1 and IL18 (show IL18 Proteins) associated with pregnancy establishment; alteration of CASP1 and IL18 (show IL18 Proteins) following premature exposure of uterus to estrogen during early pregnancy may contribute to conceptus loss between Days 15 to 18 of pregnancy

Caspase 1 (CASP1) Protein Profile

Protein Summary

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.

Alternative names and synonyms associated with Caspase 1 (CASP1)

  • Death caspase-1 (Dcp-1)
  • caspase-1 (Ice)
  • caspase-1 (AaeL_AAEL014348)
  • caspase 1 (Casp1)
  • caspase 1 (LOC100101588)
  • caspase 1, apoptosis-related cysteine peptidase (CASP1)
  • caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) (CASP1)
  • caspase 4, apoptosis-related cysteine peptidase (CASP4)
  • caspase-1-like (LOC100725217)
  • CASP1 protein
  • ccp1 protein
  • CG5370 protein
  • dcp-1 protein
  • dcp1 protein
  • Dmel\\CG5370 protein
  • ICE protein
  • IL1BC protein
  • l(2)01862 protein
  • l(2)02132 protein
  • P45 protein

Protein level used designations for Caspase 1 Proteins (CASP1)

CG5370-PA , Dcp-1-PA , caspase , caspase 1 , caspase-1 , death caspase-1 , CASP-1 , IL-1 beta-converting enzyme , IL-1B converting enzyme , IL-1BC , interleukin 1 beta-converting enzyme , interleukin-1 beta convertase , interleukin-1 beta-converting enzyme , p45 , Interleukin 1beta converting enzyme , interleukin 1, beta, convertase , CASP1 nirs variant 1 , IL1B-convertase , caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) , interleukin 1-B converting enzyme , ICE , interleukin-1 beta converting enzyme , caspase-1/caspase-4 hybrid , caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase)

37729 Drosophila melanogaster
692604 Bombyx mori
5564196 Aedes aegypti
12362 Mus musculus
25166 Rattus norvegicus
100101588 Oryctolagus cuniculus
834 Homo sapiens
397319 Sus scrofa
493961 Felis catus
100033888 Equus caballus
395764 Gallus gallus
514214 Bos taurus
403724 Canis lupus familiaris
100725217 Cavia porcellus
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