Browse our Caspase 2 Proteins (CASP2)

Full name:
Caspase 2, Apoptosis-Related Cysteine Peptidase Proteins (CASP2)
On are 24 Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) Proteins from 9 different suppliers available. Additionally we are shipping Caspase 2 Antibodies (217) and Caspase 2 Kits (27) and many more products for this protein. A total of 277 Caspase 2 products are currently listed.
CASP-2, Caspase-2, ICH-1, ICH-1L/1S, ICH1, ICH1L1S, NEDD-2, NEDD2, PPP1R57, xCaspase-2
list all proteins Gene Name GeneID UniProt
CASP2 64314 P55215
CASP2 12366 P29594
CASP2 835 P42575

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Caspase 2 Proteins (CASP2) by Origin

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Top referenced Caspase 2 Proteins

  1. Human Caspase 2 Protein expressed in Escherichia coli (E. coli) - ABIN2487271 : Chen, Xia, Fang, Hawke, Lu: Caspase-10-mediated heat shock protein 90 beta cleavage promotes UVB irradiation-induced cell apoptosis. in Molecular and cellular biology 2009 (PubMed)
    Show all 4 references for 2487271

More Proteins for Caspase 2 Interaction Partners

Xenopus laevis Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) interaction partners

  1. caspase-2 has a role as an initiator caspase (show CASP3 Proteins) in lipoapoptosis

  2. tail regression at metamorphosis implicates an apoptotic pathway inducible by T(3) hormone in an organ autonomous manner and involving the cell death executioners BH3 interacting domain death agonist (show BID Proteins) and Caspases-2 and -8

  3. Caspase-2 phosphorylated at S135 binds 14-3-3zeta (show YWHAZ Proteins), thus preventing C2 dephosphorylation.

  4. The data demonstrate that cell death is prevented during mitosis through the inhibitory phosphorylation of caspase-2 and suggest that under conditions of mitotic arrest, cdk1 (show CDK1 Proteins)-cyclin B1 (show CCNB1 Proteins) activity must be overcome for apoptosis to occur.

Mouse (Murine) Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) interaction partners

  1. These results provide the first evidence of caspase-2 in regulating haematopoietic stem cell and progenitor differentiation, as well as aneuploidy, in vivo.

  2. Study describes a novel pathological process in which caspase-2 cleavage of tau at Asp314 impairs cognitive and synaptic function in animal and cellular models of tauopathies by promoting the missorting of tau to dendritic spines.

  3. Caspase-2 deficiency protected mice from diet-induced obesity, metabolic syndrome and nonalcoholic fatty liver disease.

  4. The tumor-modulatory effects of Caspase-2 and Pidd1 do not require the scaffold protein (show HOMER1 Proteins) Raidd (show CRADD Proteins)

  5. Data show that indoles can effectively suppress acute hepatic inflammation caused by staphylococcal enterotoxin B (SEB) maybe mediated by decreased expression of miR-31 and caspase-2-dependent apoptosis in T cells.

  6. Data indicate that the nucleotide-binding domain and leucine-rich repeat containing (NLRP3 (show NLRP3 Proteins))-caspase-2 axis drives general endoplasmic reticulum (ER) stress-induced inflammasome activation.

  7. these studies elucidate a Caspase-2-p53 (show TP53 Proteins) signaling network that impacts lung tumorigenesis and chemotherapy response in vivo.

  8. data strongly suggest that caspase-2 deficiency leads to increased cellular stress largely because these mice fail to respond to oxidative stress by upregulating their antioxidant defense mechanism

  9. These results demonstrate an important role for caspase-2 in regulating proteome and metabolome remodelling during ageing.

  10. Caspase-2 is not a suppressor in MYCN (show MYCN Proteins)-induced neuroblastoma (show ARHGEF16 Proteins) and suggest a tissue and context-specific role for caspase-2 in tumorigenesis.

Human Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) interaction partners

  1. Sensitization of colon carcinoma cells to radiation-induced cell death and DNA-damage by HuR (show ELAVL1 Proteins) knockdown critically depends on caspase-2.

  2. BCL9L (show BCL9L Proteins) dysfunction contributes to aneuploidy tolerance in both TP53 (show TP53 Proteins)-WT and mutant cells by reducing basal caspase-2 levels and preventing cleavage of MDM2 (show MDM2 Proteins) and BID (show BID Proteins).

  3. CASP2 down-regulation had a reverse relationship with miR (show MLXIP Proteins)-383 down-regulation in regulating epithelial ovarian cancer development.

  4. Results suggest that mutations at all three cleavage sites of caspase-2 protein neither affect the macromolecular core complex assembly, nor modify caspase-2 activity upon DNA damage. Consequently, caspase-2 activation occurs in the macromolecular complex without its dissociation.

  5. These findings indicate that miR (show MLXIP Proteins)-125a-5p decreases after HOTAIR knockdown to promote cancer cell apoptosis by releasing caspase 2.

  6. these studies elucidate a Caspase-2-p53 (show TP53 Proteins) signaling network that impacts lung tumorigenesis and chemotherapy response in vivo.

  7. We have also demonstrated that these correlations are tissue specific being reduced (CASP9 (show CASP9 Proteins) and CASP10 (show CASP10 Proteins)) or different (CASP2) in the liver

  8. the initiator caspase-2 is required for robust death of ovarian cancer cells induced by FASN (show FASN Proteins) inhibitors

  9. HuR (show ELAVL1 Proteins) sensitizes adenocarcinoma cells to the intrinsic apoptotic pathway by upregulating the translation of caspase-2.

  10. Authors have demonstrated in vitro and in vivo that loss of function of caspase-2 allows to escape oncogenic stress induced senescence.

Cow (Bovine) Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) interaction partners

  1. EtOH-induced mitochondria-mediated apoptosis is initiated by caspase-2 activation, which is regulated by CoQ10

  2. the capacity for blastocysts to undergo further development is related to degree of group II caspase (show CASP3 Proteins) activity

Pig (Porcine) Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) interaction partners

  1. hypoxia/re-oxygenation injury in cultured proximal tubule cells induced apoptosis by activation of caspase-2, which is required for the mitochondrial translocation of Bax (show BAX Proteins).

Caspase 2 (CASP2) Protein Profile

Protein Summary

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Alternative names and synonyms associated with Caspase 2 (CASP2)

  • caspase-2-like (LOC100050611)
  • caspase-2 (xCaspase-2)
  • caspase-2 (CpipJ_CPIJ008254)
  • caspase 2 (Casp2)
  • caspase 2 (LOC100101590)
  • caspase 2, apoptosis-related cysteine peptidase (CASP2)
  • caspase 2, apoptosis-related cysteine peptidase (Casp2)
  • caspase-2-like (LOC100521118)
  • CASP-2 protein
  • Caspase-2 protein
  • ICH-1 protein
  • ICH-1L/1S protein
  • ICH1 protein
  • ICH1L1S protein
  • NEDD-2 protein
  • NEDD2 protein
  • PPP1R57 protein
  • xCaspase-2 protein

Protein level used designations for CASP2

caspase-2 , CASP-2 , ICH-1 protease , protease ICH-1 , NEDD-2 , neural precursor cell expressed developmentally down-regulated protein 2 , protein phosphatase 1, regulatory subunit 57 , caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) , ICH1 protease , caspase 2, apoptosis-related cysteine protease , cysteine protease caspase-2

100050611 Equus caballus
397817 Xenopus laevis
6040179 Culex quinquefasciatus
64314 Rattus norvegicus
12366 Mus musculus
100101590 Oryctolagus cuniculus
835 Homo sapiens
482737 Canis lupus familiaris
531419 Bos taurus
395857 Gallus gallus
100735399 Cavia porcellus
100521118 Sus scrofa
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