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Caspase 1 Proteins

(Caspase 1 (CASP1))
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012].
Caspase 1 Protein (CASP1) (AA 120-269) (His tag) Caspase 1 Protein (CASP1) (AA 120-269) (His tag) Caspase 1 Protein (CASP1) (AA 120-269) (His tag) (ABIN7122160)

CASP1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA

Caspase 1 Protein (CASP1) (AA 120-404) (His tag) Caspase 1 Protein (CASP1) (AA 120-404) (His tag) Caspase 1 Protein (CASP1) (AA 120-404) (His tag) (ABIN7122161)

CASP1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA

Caspase 1 Protein (CASP1) (AA 1-311) (GST tag) Caspase 1 Protein (CASP1) (AA 1-311) (GST tag) Caspase 1 Protein (CASP1) (AA 1-311) (GST tag) (ABIN1776262)

CASP1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP

Caspase 1 Proteins by Grade

Find Caspase 1 Proteins with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

Caspase 1 Proteins by Origin

Find Caspase 1 Proteins for a variety of species such as anti-Human Caspase 1, anti-Mouse Caspase 1, anti-Rat Caspase 1. The species listed below are among those available. Click on a link to go to the corresponding products.

Caspase 1 Proteins by Source

Here you will find Caspase 1 Proteins proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

Caspase 1 Proteins by Protein Type

Here you can find Caspase 1 Proteins proteins categorized by available protein types. Additional protein types can be located using our search function.

Caspase 1 Proteins by Application

Find Caspase 1 Proteins validated for a specific application such as ELISA, WB, SDS, Imm. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Caspase 1 Proteins by Biological Activity

Find Caspase 1 Proteins with a specific Biological Activity. The Biological Activity listed below are among those available. Click on a link to go to the corresponding products.

Popular Caspase 1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7122160
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7122161
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1776262
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1348088
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN3133626
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (3)
  • (1)
Cat. No. ABIN1046768
Quantity 50 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7505395
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7400207
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7394381
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7400210
Quantity 100 μg
Datasheet Datasheet
Reactivity Rat
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7394384
Quantity 100 μg
Datasheet Datasheet
Reactivity Pig
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7401734
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
Cat. No. ABIN3090422
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3008652
Quantity 100 μg
Datasheet Datasheet
Reactivity Rat
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN6239879
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our Caspase 1 Proteins

Han, Kim, Jeong: "The β-sitosterol attenuates atopic dermatitis-like skin lesions through down-regulation of TSLP." in: Experimental biology and medicine (Maywood, N.J.), Vol. 239, Issue 4, pp. 454-64, (2014) (PubMed).

Rizzo, De Mare, Rocchi, Stolfi, Colantoni, Neurath, Macdonald, Pallone, Monteleone, Fantini: "Smad7 induces plasticity in tumor-infiltrating Th17 cells and enables TNF-alpha-mediated killing of colorectal cancer cells." in: Carcinogenesis, Vol. 35, Issue 7, pp. 1536-46, (2014) (PubMed).

Oh, Kim, Jeong: "Distinct effects of imperatorin on allergic rhinitis: imperatorin inhibits caspase-1 activity in vivo and in vitro." in: The Journal of pharmacology and experimental therapeutics, Vol. 339, Issue 1, pp. 72-81, (2011) (PubMed).

Newman, Sirianni, Mawhinney, Lee, Leppla, Moayeri, Johansen: "Auranofin protects against anthrax lethal toxin-induced activation of the Nlrp1b inflammasome." in: Antimicrobial agents and chemotherapy, Vol. 55, Issue 3, pp. 1028-35, (2011) (PubMed).

Cheng, Chen, Best, Bloom, Pintel, Qiu: "The capsid proteins of Aleutian mink disease virus activate caspases and are specifically cleaved during infection." in: Journal of virology, Vol. 84, Issue 6, pp. 2687-96, (2010) (PubMed).

Lamkanfi, Sarkar, Vande Walle, Vitari, Amer, Wewers, Tracey, Kanneganti, Dixit: "Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 7, pp. 4385-92, (2010) (PubMed).

Murakami, Tolstykh, Bao, Niu, Steuer, Bao, Chang, Espiritu, Bansal, Lam, Otto, Sofia, Furman: "Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977." in: The Journal of biological chemistry, Vol. 285, Issue 45, pp. 34337-47, (2010) (PubMed).

Chen, Xia, Fang, Hawke, Lu: "Caspase-10-mediated heat shock protein 90 beta cleavage promotes UVB irradiation-induced cell apoptosis." in: Molecular and cellular biology, Vol. 29, Issue 13, pp. 3657-64, (2009) (PubMed).

Duncan, Gao, Huang, OConnor, Thomas, Willingham, Bergstralh, Jarvis, Sparling, Ting: "Neisseria gonorrhoeae activates the proteinase cathepsin B to mediate the signaling activities of the NLRP3 and ASC-containing inflammasome." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 10, pp. 6460-9, (2009) (PubMed).

Newman, Leppla, Moayeri: "CA-074Me protection against anthrax lethal toxin." in: Infection and immunity, Vol. 77, Issue 10, pp. 4327-36, (2009) (PubMed).

Aliases for Caspase 1 Proteins

caspase 1 (CASP1) Proteins
caspase 1 (Casp1) Proteins
caspase 1, apoptosis-related cysteine peptidase (CASP1) Proteins
caspase 4, apoptosis-related cysteine peptidase (CASP4) Proteins
Death caspase-1 (Dcp-1) Proteins
caspase-1 (Caspase1) Proteins
caspase (LOC5564196) Proteins
caspase recruitment domain-containing protein 16 (LOC451519) Proteins
caspase-1 (CASP1) Proteins
caspase 4 (CASP4) Proteins
CASP1 Proteins
ccp1 Proteins
CG5370 Proteins
DCP-1 Proteins
dcp-1 Proteins
DCP1 Proteins
Dcp1 Proteins
dcp1 Proteins
Dmel\\CG5370 Proteins
ICE Proteins
Ice Proteins
IL1BC Proteins
Il1bc Proteins
l(2)01862 Proteins
l(2)02132 Proteins
P45 Proteins
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