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Browse our anti-Caspase 3 (CASP3) Antibodies

Full name:
anti-Caspase 3, Apoptosis-Related Cysteine Peptidase Antibodies (CASP3)
On www.antibodies-online.com are 629 Caspase 3, Apoptosis-Related Cysteine Peptidase (CASP3) Antibodies from 43 different suppliers available. Additionally we are shipping Caspase 3 Kits (87) and Caspase 3 Proteins (44) and many more products for this protein. A total of 815 Caspase 3 products are currently listed.
Synonyms:
A830040C14Rik, AC-3, Apopain, Cas3, Casp 3, Casp3, caspase-3, caspase 3, CC3, CG7788, CG14902, CPP32, CPP32B, crice, Decay, Dmel\\CG7788, Dmel\\CG14902, drice, Drosophila executioner caspase related to Apopain/Yama, ice, Lice, mldy, SCA-1, xcpp32, Yama
list all antibodies Gene Name GeneID UniProt
CASP3 12367 P70677
CASP3 25402 P55213
CASP3 836 P42574

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All available anti-Caspase 3 Antibodies

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Top referenced anti-Caspase 3 Antibodies

  1. Human Polyclonal Caspase 3 Primary Antibody for IHC, WB - ABIN222873 : Fernando, Kelly, Balazsi, Slack, Megeney: Caspase 3 activity is required for skeletal muscle differentiation. in Proceedings of the National Academy of Sciences of the United States of America 2002 (PubMed)
    Show all 24 references for ABIN222873

  2. Human Polyclonal Caspase 3 Primary Antibody for WB - ABIN222951 : Atkin, Farg, Turner, Tomas, Lysaght, Nunan, Rembach, Nagley, Beart, Cheema, Horne: Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1. in The Journal of biological chemistry 2006 (PubMed)
    Show all 8 references for ABIN222951

  3. Human Polyclonal Caspase 3 Primary Antibody for EIA, FACS - ABIN951053 : Würstle, Laussmann, Rehm: The caspase-8 dimerization/dissociation balance is a highly potent regulator of caspase-8, -3, -6 signaling. in The Journal of biological chemistry 2010 (PubMed)
    Show all 5 references for ABIN951053

  4. Human Polyclonal Caspase 3 Primary Antibody for FACS, IHC (p) - ABIN655271 : Srikanth, Wall, Maldonado-Contreras, Shi, Zhou, Demma, Mumy, McCormick: Salmonella pathogenesis and processing of secreted effectors by caspase-3. in Science (New York, N.Y.) 2010 (PubMed)
    Show all 3 references for ABIN655271

  5. Human Polyclonal Caspase 3 Primary Antibody for EIA, IHC (p) - ABIN359724 : Wright, Farquhar, Aletrari, Ladds, Hodgkin: Identification of caspase 3 motifs and critical aspartate residues in human phospholipase D1b and phospholipase D2a. in Biochemical and biophysical research communications 2008 (PubMed)
    Show all 3 references for ABIN359724

  6. Human Polyclonal Caspase 3 Primary Antibody for WB - ABIN783310 : Gervais, Xu, Robertson, Vaillancourt, Zhu, Huang, LeBlanc, Smith, Rigby, Shearman, Clarke, Zheng, Van Der Ploeg, Ruffolo, Thornberry, Xanthoudakis, Zamboni, Roy, Nicholson: Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation. in Cell 1999 (PubMed)
    Show all 2 references for ABIN783310

  7. Human Polyclonal Caspase 3 Primary Antibody for DB, IHC (p) - ABIN650861 : Mei, Yong, Liu, Shi, Meinkoth, Dreyfuss, Yang: tRNA binds to cytochrome c and inhibits caspase activation. in Molecular cell 2010 (PubMed)
    Show all 2 references for ABIN650861

  8. Human Monoclonal Caspase 3 Primary Antibody for IHC (p), WB - ABIN400729 : Cartault, Munier, Benko, Desguerre, Hanein, Boddaert, Bandiera, Vellayoudom, Krejbich-Trotot, Bintner, Hoarau, Girard, Génin, de Lonlay, Fourmaintraux, Naville, Rodriguez, Feingold, Renouil, Munnich, Westhof, Fähling, Lyonnet, Henrion-Caude: Mutation in a primate-conserved retrotransposon reveals a noncoding RNA as a mediator of infantile encephalopathy. in Proceedings of the National Academy of Sciences of the United States of America 2012 (PubMed)

  9. Human Polyclonal Caspase 3 Primary Antibody for ELISA, WB - ABIN1536103 : Tewari, Quan, ORourke, Desnoyers, Zeng, Beidler, Poirier, Salvesen, Dixit: Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. in Cell 1995 (PubMed)

More Antibodies against Caspase 3 Interaction Partners

Fruit Fly (Drosophila melanogaster) Caspase 3, Apoptosis-Related Cysteine Peptidase (CASP3) interaction partners

  1. Genetic characterization of two gain-of-function alleles of the effector caspase DrICE in Drosophila.

  2. drICE plays an important role in activating corpse clearance in dying cells, and that an additional function of effector caspases is required for the activation of corpse clearance as well as that for carrying out cell death.

  3. Both autophagy and caspase activity are induced by 20-hydroxyecdysone during the larval-prepupal transition.

  4. The cleaved DIAP1 (show DIAPH1 Antibodies) binds drICE, inhibits its protease activity, and also targets drICE for ubiquitylation.

  5. Drosophila corazonin-producing interneuron programmed cell death utilizes dronc, strica, dcp-1 (show ACE Antibodies), and ice

  6. Data suggest that the cleaved-Caspase-3 antibody recognizes multiple proteins including DCP-1 (show ACE Antibodies) and likely DRICE, but also at least one additional unknown protein, all of which require DRONC for epitope exposure.

  7. The caspase effector DRICE is activated during apoptosis in both mid- and late oogenesis; however, active DRICE was found more ubiquitously and at a higher level during germline cell death in midoogenesis.

  8. examination of inhibition by DIAP1 (show DIAPH1 Antibodies)

  9. Ecdysone-mediated up-regulation of the effector caspase DRICE is required for hormone-dependent apoptosis in Drosophila cells.

  10. A double-mutant analysis between drICE and death caspase-1 (dcp-1), another effector caspase, reveals that some cells (type I) strictly require drICE for apoptosis, whereas other cells (type II) require either drICE or dcp-1 (show ACE Antibodies).

Mouse (Murine) Caspase 3, Apoptosis-Related Cysteine Peptidase (CASP3) interaction partners

  1. Conversely, treatment with LY294002 (a selective inhibitor of Akt1 (show AKT1 Antibodies)) reversed the effects of quercetin. In conclusion, these findings highlight the important role of quercetin in protecting against cognitive deficits and inhibiting neuronal apoptosis via the Akt (show AKT1 Antibodies) signaling pathway. We believe that quercetin might prove to be a useful therapeutic component in treating cerebral I/R diseases in the near future.

  2. cognitive decline was significantly correlated with increased levels of caspase activity and tau truncated by caspase-3

  3. this study shows that Le Carbone, a charcoal supplement, attenuates experimental colitis through caspase 3 dependent apoptotic pathways

  4. Cepharanthine treatment reduced mitochondrial membrane potential and upregulated the level of cleaved caspases, including caspase-9 (show CASP9 Antibodies) and caspase-3/7, in a dose-dependent fashion.

  5. Our results showed that Sca-1 (show Ly6a Antibodies)(+) MSCs inhibit the commitment of marginal zone B lymphocytes. The inhibition was exerted through lowered Caspase-3 expression. Furthermore, we found marginal zone B lymphocytes in spleen of Caspase-3 knockout mice decreased and Caspase-3 knockout Sca-1 (show Ly6a Antibodies)(+) MSCs accounted for the MZB lymphocytes decrease.

  6. caspase-3 is essential for a subset of social behaviors, but despite similar hyper-locomotion in both sexes, only male Casp3(-/-) mice exhibited social interaction deficits, which is interesting given the male bias of autism

  7. Study identified CASP-3 mRNA as a new miRNA-155 target in lipopolysaccharides-activated macrophages suggesting that through destabilization of CASP-3, miR (show MLXIP Antibodies)-155 contributes to the protective role to sustain macrophage function in inflammation response.

  8. expression level of miR (show MLXIP Antibodies)-98, which can regulate Caspase-3, was significantly decreased. Huwe1, the host gene of miR (show MLXIP Antibodies)-98, was positively associated with miR (show MLXIP Antibodies)-98 expression after Silica NP exposure

  9. administration of 0.3 IU/mL FSH (show BRD2 Antibodies) during ovarian cryopreservation by vitrification can maintain ovarian survival during ovarian vitrification and increases the blood supply with avascular transplantation via upregulation of Cx43 (show GJA1 Antibodies), Cx37 (show GJA4 Antibodies), and VEGF (show VEGFA Antibodies)/VEGFR2 (show KDR Antibodies)

  10. indicates that the up-regulation of ROCK1 (show ROCK1 Antibodies) activity in RhoA (show RHOA Antibodies)-deleted macrophages and macrophage phenotype/polarity are dependent on non-apoptotic Caspase-3 and are sensitive to Caspase-3 inhibition

Human Caspase 3, Apoptosis-Related Cysteine Peptidase (CASP3) interaction partners

  1. LRRC8A (show LRRC8A Antibodies) is an essential regulator of cisplatin induced p53 (show TP53 Antibodies) protein activity and its downstream signaling involving increased expression of p21Waf1/Cip1 and MDM2 (show MDM2 Antibodies), as well as activation of caspase-9 (show CASP9 Antibodies) and -3 in tumor cell lines.

  2. Our results provide evidence that inhibition of the denitrosylation of S-nitrosylated procaspase-3 mediated by the redox protein Trx2 is a part of the microglial pro-tumoral activation pathway initiated by glioma cancer cells.

  3. These results highlight apoptosis-related CASP3 as an important gene in human carcinogenesis and further support the CASP3 polymorphisms confer to the lung cancer susceptibility.

  4. These findings revealed that rs4647693 G/A, rs4647610 A/G, and rs12108497 T/C polymorphisms of Caspase-3 may be associated with susceptibility to intervertebral disc herniation.

  5. the present study demonstrated that DAPK (show DAPK1 Antibodies) contributed to the Hcyinduced endothelial apoptosis via modulation of Bcl2 (show BCL2 Antibodies)/Bax (show BAX Antibodies) expression levels and activation of caspase 3

  6. Data show that the apoptotic and cytotoxic effects of BL-038 are mediated by the intrinsic mitochondria-mediated apoptotic pathway, which in turn causes the activation of caspase-9 (show CASP9 Antibodies) and caspase-3, and the cleavage of poly (ADP-ribose) polymerase (PARP (show PARP1 Antibodies)), to elicit apoptosis response.

  7. Data show that MeCP2 (show MECP2 Antibodies) promotes gastric cancer (GC) cell proliferation via FOXF1 (show FOXF1 Antibodies)-mediated Wnt5a (show WNT5A Antibodies)/beta-Catenin (show CTNNB1 Antibodies) signaling pathway, and suppresses GC cell apoptosis through MYOD1 (show MYOD1 Antibodies)-mediated Caspase-3 signaling pathway.

  8. Caspase-3 signaling pathway is involved in breast cancer cells apoptosis.

  9. Downregulation of DNMT3a (show DNMT3A Antibodies) regulated miR (show MLXIP Antibodies)-182 via caspase-3 and -9-mediated apoptosis and DNA damage response in ovarian cancer.

  10. High incidence of renal tubular necrosis is documented in severe P. falciparum malaria with acute kidney injury, and is associated with the occurrence of apoptosis and expression of cleaved caspase 3.

Cow (Bovine) Caspase 3, Apoptosis-Related Cysteine Peptidase (CASP3) interaction partners

  1. Over-expression of STC-1 (show STC1 Antibodies) up-regulated Bcl-2 (show BCL2 Antibodies) protein expression and slightly down-regulated caspase-3 production in the damaged cells. Findings from this study suggest that STC-1 (show STC1 Antibodies) plays a protective role in intestinal cells through an antioxidant mechanism.

  2. Data suggest that Escherichia coli infections (here, administration of LPS (show IRF6 Antibodies)) provokes luteolysis in diestrus, non-lactating cows and up-regulation of expression of caspase 3 in corpus luteum but has no effect on luteinization in the following cycle.

  3. Data suggest that activation of caspase-3 is likely involved in both spontaneous and induced apoptosis in bovine pre-implantation embryos.

  4. mRNA expression of Bax (show BAX Antibodies), Bcl-2 (show BCL2 Antibodies), caspase-3 and-7 cannot be used as a reliable apoptosis detection method.

  5. the capacity for blastocysts to undergo further development is related to degree of group II caspase activity

  6. Treatment of mammary epithelial cells with serotonin 1B and serotonin 2A receptor antagonists increased caspase-3 activity.

Pig (Porcine) Caspase 3, Apoptosis-Related Cysteine Peptidase (CASP3) interaction partners

  1. This study demonstrated that LAMPs from M. hyopneumoniae can induce apoptosis in St. Jude porcine lung epithelial cell line through the activation of caspase 3, caspase 8 (show CASP8 Antibodies), cyt c (show CYCS Antibodies), Bax (show BAX Antibodies), and p38 MAPK (show MAPK14 Antibodies).

  2. Caspase-3 (CC3) was shown to be more abundant in early-cleaving and more developmentally competent embryos compared to late-cleaving and less developmentally competent embryos.

  3. Results suggest that zearalenone induces apoptosis and necrosis of porcine granulosa cells in a dose-dependent manner via a caspase-3- and caspase-9 (show CASP9 Antibodies)-dependent mitochondrial pathway.

  4. FiO2 used for resuscitation affects matrix metalloproteinases MMP-9 (show MMP9 Antibodies) and MMP-2 (show MMP2 Antibodies), caspase-3 and BDNF (show BDNF Antibodies)

  5. both caspase-3-dependent and -independent pathways of programmed cell death increased upon Salmonella typhimurium infection.

  6. clonidine administration prior to hypoxia prevents the hypoxia-induced increase in the activity of caspase-3 in the cerebral cortex.

  7. Suppressive effect of FSH (show BRD2 Antibodies) and LH on p53 (show TP53 Antibodies) expression and caspase-3 activity with parallel increase in bcl-2 (show BCL2 Antibodies) expression and increased P production was observed

  8. Ischemic preconditioning exerts a powerful protective effect against hepatic ischemia-reperfusion injury in the early phase of reperfusion, which may be mediated by preservation of mitochondrial structure and inhibition of caspase-3 activity.

Rabbit Caspase 3, Apoptosis-Related Cysteine Peptidase (CASP3) interaction partners

  1. excessive apoptosis does occur in acetabular cartilage with developmental dislocations of the hip, and is positively correlated with high caspase-3 expression as well as low Bcl-2 (show BCL2 Antibodies) expression.

  2. This study revealed that the 810-nm low-level laser can improve cartilage structure, prevent articular cartilage degradation and significantly decrease the expression of caspase-3 in this surgery-induced osteoarthritis model.

  3. Morphine hypoxic preconditioning can protect rabbits against acute kidney hypoxic/reoxygenation injury by decreasing expression of caspase-3.

  4. Isoflurane delayed preconditioning can inhibit the apoptosis of myocardium by up-regulating the expression of Bcl-2 (show BCL2 Antibodies) and down-regulating the activation of caspase-3.

  5. High frequency oscillatory ventilation combined with exogenous pulmonary surfactant can decrease the concentration of caspase-3 and p73 (show ARHGAP24 Antibodies) rabbit with acute respiratory failure.

Xenopus laevis Caspase 3, Apoptosis-Related Cysteine Peptidase (CASP3) interaction partners

  1. Hyperosmotic Shock Engages Two Positive Feedback Loops through Caspase-3-dependent Proteolysis of JNK1 (show MAPK8 Antibodies)-2 and Bid (show BID Antibodies).

  2. in the developing diencephalon, Caspase3 acts downstream of Barhl2 (show BARHL2 Antibodies) in limiting neuroepithelial cell proliferation by inhibiting beta-catenin (show CTNNB1 Antibodies) activation.

  3. PP2A:B56{epsilon}, a substrate of caspase-3, regulates p53 (show TP53 Antibodies)-dependent and p53 (show TP53 Antibodies)-independent apoptosis during development.

Caspase 3 (CASP3) Antigen Profile

Antigen Summary

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.

Alternative names and synonyms associated with Caspase 3 (CASP3)

  • caspase 3, apoptosis-related cysteine peptidase (CASP3) antibody
  • death executioner caspase related to Apopain/Yama (decay) antibody
  • CG7788 gene product from transcript CG7788-RA (Ice) antibody
  • caspase 3 (Casp3) antibody
  • caspase 3, apoptosis-related cysteine peptidase (Casp3) antibody
  • caspase 3, apoptosis-related cysteine peptidase (casp3) antibody
  • A830040C14Rik antibody
  • AC-3 antibody
  • Apopain antibody
  • Cas3 antibody
  • Casp 3 antibody
  • Casp3 antibody
  • caspase-3 antibody
  • caspase 3 antibody
  • CC3 antibody
  • CG7788 antibody
  • CG14902 antibody
  • CPP32 antibody
  • CPP32B antibody
  • crice antibody
  • Decay antibody
  • Dmel\\CG7788 antibody
  • Dmel\\CG14902 antibody
  • drice antibody
  • Drosophila executioner caspase related to Apopain/Yama antibody
  • ice antibody
  • Lice antibody
  • mldy antibody
  • SCA-1 antibody
  • xcpp32 antibody
  • Yama antibody

Protein level used designations for CASP3

Caspase-3-like protein , caspase-3 , CG14902-PA , Caspase-3 , caspase 3 , caspase-3 protein , cleaved caspase 3 , decay-PA , CG7788-PA , Ice-PA , drice , interleukin-1beta-converting enzyme , CASP-3 , CPP-32 , SCA-1 , SREBP cleavage activity 1 , caspase 3, apoptosis related cysteine protease , cysteine protease CPP32 , protein Yama , CPP32beta , Caspase 3 apoptosis related cysteine protease (ICE-like cysteine protease) , Caspase 3, apoptosis related cysteine protease (ICE-like cysteine protease) , IRP , apopain , yama protein , PARP cleavage protease , caspase 3, apoptosis-related cysteine protease , procaspase3

GENE ID SPECIES
100034083 Equus caballus
42008 Drosophila melanogaster
43514 Drosophila melanogaster
12367 Mus musculus
25402 Rattus norvegicus
836 Homo sapiens
408016 Bos taurus
403567 Canis lupus familiaris
397244 Sus scrofa
443031 Ovis aries
100008840 Oryctolagus cuniculus
395476 Gallus gallus
100718309 Cavia porcellus
493932 Felis catus
397720 Xenopus laevis
461669 Pan troglodytes
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