Browse our CD11b Proteins (ITGAM)

Full name:
Integrin alpha M Proteins (ITGAM)
On are 21 Integrin alpha M (ITGAM) Proteins from 7 different suppliers available. Additionally we are shipping CD11b Antibodies (1042) and CD11b Kits (21) and many more products for this protein. A total of 1089 CD11b products are currently listed.
C3bi, CD11B, CD11b/CD18, CR3, CR3A, F730045J24Rik, Ly-40, MAC-1, Mac-1a, MAC1, MAC1A, MO1A, SLEB6
list all proteins Gene Name GeneID UniProt
ITGAM 16409  
ITGAM 25021  
ITGAM 3684 P11215

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CD11b Proteins (ITGAM) by Origin

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More Proteins for CD11b Interaction Partners

Mouse (Murine) Integrin alpha M (ITGAM) interaction partners

  1. The single nucleotide polymorphism rs1143678 substitutes Pro(1146) for Ser (show SIGLEC1 Proteins) in the integrin alphaM cytoplasmic tail generates a noncanonical 14-3-3zeta (show YWHAZ Proteins) binding site that modulates integrin alphaM(PS)beta2 outside-in signaling

  2. a novel role for CR3 and microglia in brain Abeta (show APP Proteins) metabolism and defining a potential new therapeutic target in Alzheimer disease.

  3. Oral treatment with the mucosal adjuvant cholera toxin (CT) induces expression of T cell immunoglobulin and mucin domain containing 4 (TIM-4 (show TIMD4 Proteins)) on a proportion of CD103 (show ITGAE Proteins)+ CD11b+ dendritic cell (DC) in the intestinal lamina propria (LP).

  4. this study shows that genetic deletion of CD11b confers collagen-induced arthritis susceptibility through IL-6 (show IL6 Proteins)-mediated Th17 differentiation in C57BL/6 mice, which are normally resistant to this disease

  5. RBC (show CACNA1C Proteins)-leukocyte interactions are significantly diminished in Mac-1-deficient SCD (show SCD Proteins) mice, leading to an improvement of blood flow rates and prolonged survival time in a tumor necrosis factor-alpha (show TNF Proteins) and surgical-trauma-induced VOC model. Mac-1-deletion, however, was not sufficient to reduce SCD (show SCD Proteins)-related chronic organ damage.

  6. The results indicate that both Mac-1 and alphaDbeta2 support macrophage fusion with Mac-1 playing a dominant role

  7. Intestinal CD103 (show ITGAE Proteins)(+)CD11b(-) dendritic cells restrain colitis via IFN-gamma-induced (show SAMHD1 Proteins) anti-inflammatory response in epithelial cells.

  8. CD11b immunophenotyping identifies inflammatory profiles in the mouse and human lungs.

  9. this study demonstrates the feasibility of anti-CD11b antibody mediated noninvasive SPECT/CT imaging of inflammatory leukocytes in murine atherosclerotic plaques

  10. Antigen-specific cytotoxic T lymphocytes target airway CD103 (show ITGAE Proteins)+ and CD11b+ dendritic cells to suppress allergic inflammation.

Human Integrin alpha M (ITGAM) interaction partners

  1. FRbeta (show FOLR2 Proteins) as a novel CD11b/CD18 regulator for trafficking and homing of a subset of macrophages on collagen.

  2. this study shows that upregulation of CD11b after stimulation with IL-8 (show IL8 Proteins) is more pronounced in adults than in neonates, whereas fMLP (show FPR1 Proteins) induces changes in receptor expression that are of the same magnitude in neutrophils from neonates as from adults

  3. Ingestion of amino acid supplement did not influence CD11b expression.

  4. This metaanalysis indicates that polymorphisms in the pathways of immune complex clearance, such as the FcgammaRIIIa, FcgammaRIIIb, and ITGAM genotypes, are potential susceptibility genes for neuropsychiatric systemic lupus erythematosus.

  5. Monocyte-platelet aggregates and CD11b expression on monocytes and granulocytes are increased in atrial fibrillation patients with proven thrombus formation. They seem to be appropriate biomarkers for stratification of thromboembolic risk in patients with AF.

  6. CD11b immunophenotyping identifies inflammatory profiles in the mouse and human lungs.

  7. There is direct interaction between C3(H2O) and CD11b. Contact-activated C3(H2O) is a novel ligand for CD11b/CD18 that mediates platelet-PMN (show TBCE Proteins) complex formation and the binding of platelet-derived microparticles to PMNs.

  8. Data show that secreted aspartic protease 2 (Sap2) of Candida albicans inactivates human macrophage complement factor H (factor H (show CFH Proteins)), factor H (show CFH Proteins)-receptors CD11b/CD18 and CD11c (show ITGAX Proteins)/CD18 (show ITGB2 Proteins).

  9. we confirmed the similarities between epithelial ovarian cancer and fallopian tube, normal and adenocarcinoma using FOLR1 (show FOLR1 Proteins), FOLR2 (show FOLR2 Proteins), CD68 (show CD68 Proteins) and CD11b markers

  10. While total surface expression of CD11b and L-selectin (show SELL Proteins) on neutrophils was largely unaffected

Cow (Bovine) Integrin alpha M (ITGAM) interaction partners

  1. These data describe the presence of specific pattern recognition receptor transcripts in the mRNA isolated from bovine neutrophil and show a CD11b-/Ca(2 (show CA2 Proteins)+) dependent ROS (show ROS1 Proteins) production

  2. The molecular cloning and characterization of CD11b from cattle and its similarities to other species are presented.

Pig (Porcine) Integrin alpha M (ITGAM) interaction partners

CD11b (ITGAM) Protein Profile

Protein Summary

This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with CD11b (ITGAM)

  • integrin, alpha M (complement component 3 receptor 3 subunit) (ITGAM)
  • integrin alpha M (Itgam)
  • integrin, alpha M (Itgam)
  • integrin, alpha M (complement component 3 receptor 3 subunit) (Itgam)
  • C3bi protein
  • CD11B protein
  • CD11b/CD18 protein
  • CR3 protein
  • CR3A protein
  • F730045J24Rik protein
  • Ly-40 protein
  • MAC-1 protein
  • Mac-1a protein
  • MAC1 protein
  • MAC1A protein
  • MO1A protein
  • SLEB6 protein

Protein level used designations for Integrin alpha M Proteins (ITGAM)

MAC-1 alpha subunit , integrin alpha M , integrin alpha-M , CD11 antigen-like family member B , CD11B (p170) , CR-3 alpha chain , Mac-1 alpha , cell surface glycoprotein MAC-1 alpha subunit , cell surface glycoprotein MAC-1 subunit alpha , complement component receptor 3 alpha-a , complement receptor type 3 , leukocyte adhesion receptor MO1 , macrophage antigen alpha , antigen CD11b (p170) , macrophage antigen alpha polypeptide , neutrophil adherence receptor alpha-M subunit , leukocyte integrin alpha-M chain , complement receptor 3 , leukocyte integrin alpha M

454069 Pan troglodytes
16409 Mus musculus
25021 Rattus norvegicus
3684 Homo sapiens
407124 Bos taurus
443217 Ovis aries
397459 Sus scrofa
489928 Canis lupus familiaris
100351865 Oryctolagus cuniculus
100135561 Cavia porcellus
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