Browse our CFLAR (CFLAR) ELISA Kits

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CASP8 and FADD-Like Apoptosis Regulator ELISA Kits (CFLAR)
On are 9 CASP8 and FADD-Like Apoptosis Regulator (CFLAR) ELISA Kits from 7 different suppliers available. Additionally we are shipping CFLAR Antibodies (298) and CFLAR Proteins (13) and many more products for this protein. A total of 341 CFLAR products are currently listed.
2310024N18Rik, A430105C05Rik, c-Flip, c-FLIPL, c-FLIPR, c-FLIPS, Cash, CASP8AP1, Casper, CFLAR, CLARP, Clarp1, ENSMUSG00000072980, FLAME, FLAME-1, FLAME1, Flip, Gm9845, I-FLICE, MRIT
list all ELISA KIts Gene Name GeneID UniProt
CFLAR 8837 O15519
CFLAR 12633 O35732
Rat CFLAR CFLAR 117279  

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Human CASP8 and FADD-Like Apoptosis Regulator (CFLAR) interaction partners

  1. findings suggest that expression of cFLIPL regulates the basal interaction of Bcl-2 (show BCL2 ELISA Kits) with Beclin-1 (show BECN1 ELISA Kits) and substantiates p53 (show TP53 ELISA Kits) dependent ubiquitination of Beclin-1 (show BECN1 ELISA Kits) during autophagic stress to determine the fate of cell death or survival.

  2. Using the tDED filament structure as a template, structural analyses reveal the interaction surfaces between FADD (show FADD ELISA Kits) and caspase-8 (show CASP8 ELISA Kits) and the distinct mechanisms of regulation by cFLIP and MC159 through comingling and capping, respectively.

  3. Data in this study show that cFLIPL inhibits IFN regulatory factor 3 (IRF3 (show IRF3 ELISA Kits)), a transcription factor central for IFN-beta (show IFNB1 ELISA Kits) and IFN-stimulated gene expression.

  4. CFLAR levels were substantially decreased in the livers of subjects with NAFLD and NASH, as compared to that in nonsteatotic controls.

  5. association of c-FLIPL and TIP49 provided an additional mechanism involved in c-FLIPL-mediated functions, including Wnt (show WNT2 ELISA Kits) activation

  6. CFLAR role in the necroptosis in fibroblasts

  7. TRAIL can enhance RIP1 and c-FLIPL expression in HepG2 cells.

  8. Combined triple actions of the TRAIL, the IAPs inhibitor, AT406, and the c-FLIP expression inhibitor, rocaglamide (ART), markedly improve TRAIL-induced apoptotic effects in most solid cancer cell lines through the activation of an extrinsic apoptosis pathway

  9. Our results postulate that thymoquinone induces apoptosis through downregulating c-FLIP and Bcl-2 (show BCL2 ELISA Kits) which can be utilized as a chemotherapeutic agent to treat renal carcinoma (show TSC2 ELISA Kits).

  10. knockdown of cFLIPL and induced expression of FADD (show FADD ELISA Kits) rapidly accumulate intracellular ROS (show ROS1 ELISA Kits) accompanied by JNK1 (show MAPK8 ELISA Kits) activation to substantiate apoptosis.

Mouse (Murine) CASP8 and FADD-Like Apoptosis Regulator (CFLAR) interaction partners

  1. Findings establish CFLAR as a key suppressor of steatohepatitis and indicate that the development of CFLAR-peptide-mimicking drugs and the screening of small-molecular inhibitors that specifically block ASK1 (show MAP3K5 ELISA Kits) dimerization are new and feasible approaches for NASH (show SAMSN1 ELISA Kits) treatment.

  2. knockdown of cFLIPL and induced expression of FADD (show FADD ELISA Kits) rapidly accumulate intracellular ROS (show ROS1 ELISA Kits) accompanied by JNK1 (show MAPK8 ELISA Kits) activation to substantiate apoptosis.

  3. CASP8 (show CASP8 ELISA Kits) is present exclusively as its cleaved p43 (show AIMP1 ELISA Kits) product, bound to cFLIPL.

  4. The generation of mouse line with Flip deficiency in cells that express cre under the CD11c (show ITGAX ELISA Kits) promoter is reported.

  5. c-FLIPL deficiency induces the caspase (show CASP3 ELISA Kits)-mediated processing of RTN4 (show RTN4 ELISA Kits), thus affecting endoplasmic reticulum (ER) shape and coupling to mitochondria. Thus, it was concluded that c-FLIPL is a novel regulator of ER morphology and ER-mitochondria crosstalk.

  6. Acute organ failure following the loss of anti-apoptotic cellular FLICE-inhibitory protein involves activation of innate immune receptors.

  7. The results reveal a novel inhibitory role of c-FLIP in myeloid cell activation and demonstrate the unexpected anti-inflammatory activity of c-FLIP.

  8. Upon starvation, c-Flip affects lipid accumulation, ER stress and autophagy, thereby pointing to an important role of c-Flip in the adaptive response and ER stress response programs under both normal and pathological conditions.

  9. Flip preserves cardiac functions and inhibits cardiac hypertrophy partially by blocking ASK1 (show MAP3K5 ELISA Kits)/P38 (show CRK ELISA Kits) signaling.

  10. These data suggest that c-FLIP is a negative regulator of intrinsic apoptosis pathway in T lymphocytes.

Cow (Bovine) CASP8 and FADD-Like Apoptosis Regulator (CFLAR) interaction partners

  1. results indicate downregulation of cFLIP during structural luteal regression, suggesting that cFLIP plays a survival role in the bovine corpus luteum

  2. Conservation of FLIP's ability to inhibit apoptosis and to downregulate NF-kappaB (show NFKB1 ELISA Kits) activation across species.

Pig (Porcine) CASP8 and FADD-Like Apoptosis Regulator (CFLAR) interaction partners

  1. cellular-Flice like inhibitory protein (cFLIP) long form, plays an anti-apoptotic role in the granulosa cells of healthy follicles of pig ovaries [cFLIP]

  2. Intracellular remodeling with overexpression of pig c (show PIGC ELISA Kits)-FLIP in xenograft cells may decrease the innate cellular responses against xenografts, facilitating long-term xenograft survival.

  3. Intracellular remodeling with the overexpression of c-FLIP(S/L) in xenograft cells may avoid innate cellular attacks against xenografts and facilitate long-term xenograft survival.

  4. Overexpression of c-FLIP in xenograft cells may prevent innate cellular attacks against xenografts opening the window of opportunity for long-term xenograft survival.

CFLAR Antigen Profile

Antigen Summary

The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists.

Alternative names and synonyms associated with CFLAR

  • CASP8 and FADD-like apoptosis regulator a (cflara) Elisa Kit
  • CASP8 and FADD-like apoptosis regulator (CFLAR) Elisa Kit
  • CASP8 and FADD-like apoptosis regulator (cflar) Elisa Kit
  • CASP8 and FADD-like apoptosis regulator (Cflar) Elisa Kit
  • cellular FLICE-like inhibitory protein (C-FLIP) Elisa Kit
  • 2310024N18Rik Elisa Kit
  • A430105C05Rik Elisa Kit
  • c-Flip Elisa Kit
  • c-FLIPL Elisa Kit
  • c-FLIPR Elisa Kit
  • c-FLIPS Elisa Kit
  • Cash Elisa Kit
  • CASP8AP1 Elisa Kit
  • Casper Elisa Kit
  • CFLAR Elisa Kit
  • CLARP Elisa Kit
  • Clarp1 Elisa Kit
  • ENSMUSG00000072980 Elisa Kit
  • FLAME Elisa Kit
  • FLAME-1 Elisa Kit
  • FLAME1 Elisa Kit
  • Flip Elisa Kit
  • Gm9845 Elisa Kit
  • I-FLICE Elisa Kit
  • MRIT Elisa Kit

Protein level used designations for CFLAR

FLIP , CASP8 and FADD-like apoptosis regulator , flice/caspase-i inhibitory protein , cellular FLICE-like inhibitory protein , CASP8 and FADD-like apoptosis regulator-like , FADD-like anti-apoptotic molecule , FADD-like antiapoptotic molecule 1 , MACH-related inducer of toxicity , caspase homolog , caspase-eight-related protein , caspase-like apoptosis regulatory protein , caspase-related inducer of apoptosis , inhibitor of FLICE , usurpin beta , usurpin , FLICE-like inhibitory protein

373114 Danio rerio
424080 Gallus gallus
459872 Pan troglodytes
574234 Macaca mulatta
779578 Xenopus (Silurana) tropicalis
780745 Xenopus laevis
100142680 Felis catus
100393782 Callithrix jacchus
100474872 Ailuropoda melanoleuca
100589650 Nomascus leucogenys
8837 Homo sapiens
12633 Mus musculus
488471 Canis lupus familiaris
497199 Bos taurus
117279 Rattus norvegicus
100172025 Pongo abelii
414381 Sus scrofa
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