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Browse our CFLAR (CFLAR) ELISA Kits

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CASP8 and FADD-Like Apoptosis Regulator ELISA Kits (CFLAR)
On are 4 CASP8 and FADD-Like Apoptosis Regulator (CFLAR) ELISA Kits from 2 different suppliers available. Additionally we are shipping CFLAR Antibodies (213) and CFLAR Proteins (12) and many more products for this protein. A total of 251 CFLAR products are currently listed.
2310024N18Rik, A430105C05Rik, c-Flip, c-FLIPL, c-FLIPR, c-FLIPS, Cash, CASP8AP1, Casper, CFLAR, CLARP, Clarp1, ENSMUSG00000072980, FLAME, FLAME-1, FLAME1, Flip, Gm9845, I-FLICE, MRIT
list all ELISA KIts Gene Name GeneID UniProt
CFLAR 8837 O15519
CFLAR 12633 O35732
Rat CFLAR CFLAR 117279  

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Human CASP8 and FADD-Like Apoptosis Regulator (CFLAR) interaction partners

  1. Our findings suggested that GA induces apoptosis via the downregulation of cFLIPL and sensitized TRAIL-mediated apoptosis in Caki (show CASK ELISA Kits) cells.

  2. A dual role for cFLIP in the maintenance of breast cancer stem cell viability, dependent upon its subcellular distribution.

  3. This conservation of IKK (show CHUK ELISA Kits) activation among the cFLIP family using different mechanisms suggests that the mechanism plays a critical role in their function.

  4. procaspase-8:c-FLIPL exhibits localized enzymatic activity and is preferentially an activator, promoting DED (show AATF ELISA Kits)-mediated procaspase-8 oligomer assembly, whereas procaspase-8:c-FLIPS lacks activity and potently blocks procaspase-8 activation

  5. Reduced miR (show MLXIP ELISA Kits)-512 and the elevated expression of its targets cFLIP and MCL1 (show MCL1 ELISA Kits) localize to neurons with hyperphosphorylated Tau protein in Alzheimer disease.

  6. CDDO-Me rapidly reduced the protein levels of c-FLIPL and overexpression of c-FLIPL blocked CDDO-Me-induced cell death, but not vacuolation

  7. Identification and Characterization of the Interaction Site between cFLIPL and Calmodulin (show CALM1 ELISA Kits).

  8. c-FLIP and RIP (show HRB ELISA Kits) can inhibit caspase-8 (show CASP8 ELISA Kits) activation and prompting HepG2 and Hep3B resistant to cell apoptosis induced by TRAIL.

  9. The result indicated that TMZ may overcome TRAIL resistance in GSCs by suppressing c-FLIP expression through c-Cbl (show CBL ELISA Kits)-mediated ubiquitination and degradation

  10. Activation of AKR1C1 (show DDH ELISA Kits)/ERbeta (show ESR2 ELISA Kits) induces apoptosis by downregulation of c-FLIP in prostate cancer cells.

Mouse (Murine) CASP8 and FADD-Like Apoptosis Regulator (CFLAR) interaction partners

  1. CASP8 (show CASP8 ELISA Kits) is present exclusively as its cleaved p43 (show AIMP1 ELISA Kits) product, bound to cFLIPL.

  2. The generation of mouse line with Flip deficiency in cells that express cre under the CD11c (show ITGAX ELISA Kits) promoter is reported.

  3. c-FLIPL deficiency induces the caspase (show CASP3 ELISA Kits)-mediated processing of RTN4 (show RTN4 ELISA Kits), thus affecting endoplasmic reticulum (ER) shape and coupling to mitochondria. Thus, it was concluded that c-FLIPL is a novel regulator of ER morphology and ER-mitochondria crosstalk.

  4. Acute organ failure following the loss of anti-apoptotic cellular FLICE-inhibitory protein involves activation of innate immune receptors.

  5. The results reveal a novel inhibitory role of c-FLIP in myeloid cell activation and demonstrate the unexpected anti-inflammatory activity of c-FLIP.

  6. Upon starvation, c-Flip affects lipid accumulation, ER stress and autophagy, thereby pointing to an important role of c-Flip in the adaptive response and ER stress response programs under both normal and pathological conditions.

  7. Flip preserves cardiac functions and inhibits cardiac hypertrophy partially by blocking ASK1 (show MAP3K5 ELISA Kits)/P38 (show CRK ELISA Kits) signaling.

  8. These data suggest that c-FLIP is a negative regulator of intrinsic apoptosis pathway in T lymphocytes.

  9. c-FLIPR is an important modulator of apoptosis and enforced expression leads to autoimmunity.

  10. cFLIP protein expression from one allele of cFLIP is sufficient to protect epidermal keratinocytes from cell death and a macroscopic phenotype upon acute ablation of the cFLIP locus.

Cow (Bovine) CASP8 and FADD-Like Apoptosis Regulator (CFLAR) interaction partners

  1. results indicate downregulation of cFLIP during structural luteal regression, suggesting that cFLIP plays a survival role in the bovine corpus luteum

  2. Conservation of FLIP's ability to inhibit apoptosis and to downregulate NF-kappaB (show NFKB1 ELISA Kits) activation across species.

Pig (Porcine) CASP8 and FADD-Like Apoptosis Regulator (CFLAR) interaction partners

  1. cellular-Flice like inhibitory protein (cFLIP) long form, plays an anti-apoptotic role in the granulosa cells of healthy follicles of pig ovaries [cFLIP]

  2. Intracellular remodeling with overexpression of pig c (show PIGC ELISA Kits)-FLIP in xenograft cells may decrease the innate cellular responses against xenografts, facilitating long-term xenograft survival.

  3. Intracellular remodeling with the overexpression of c-FLIP(S/L) in xenograft cells may avoid innate cellular attacks against xenografts and facilitate long-term xenograft survival.

  4. Overexpression of c-FLIP in xenograft cells may prevent innate cellular attacks against xenografts opening the window of opportunity for long-term xenograft survival.

CFLAR Antigen Profile

Antigen Summary

The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists.

Alternative names and synonyms associated with CFLAR

  • CASP8 and FADD-like apoptosis regulator a (cflara) Elisa Kit
  • CASP8 and FADD-like apoptosis regulator (CFLAR) Elisa Kit
  • CASP8 and FADD-like apoptosis regulator (cflar) Elisa Kit
  • CASP8 and FADD-like apoptosis regulator (Cflar) Elisa Kit
  • cellular FLICE-like inhibitory protein (C-FLIP) Elisa Kit
  • 2310024N18Rik Elisa Kit
  • A430105C05Rik Elisa Kit
  • c-Flip Elisa Kit
  • c-FLIPL Elisa Kit
  • c-FLIPR Elisa Kit
  • c-FLIPS Elisa Kit
  • Cash Elisa Kit
  • CASP8AP1 Elisa Kit
  • Casper Elisa Kit
  • CFLAR Elisa Kit
  • CLARP Elisa Kit
  • Clarp1 Elisa Kit
  • ENSMUSG00000072980 Elisa Kit
  • FLAME Elisa Kit
  • FLAME-1 Elisa Kit
  • FLAME1 Elisa Kit
  • Flip Elisa Kit
  • Gm9845 Elisa Kit
  • I-FLICE Elisa Kit
  • MRIT Elisa Kit

Protein level used designations for CFLAR

FLIP , CASP8 and FADD-like apoptosis regulator , flice/caspase-i inhibitory protein , cellular FLICE-like inhibitory protein , CASP8 and FADD-like apoptosis regulator-like , FADD-like anti-apoptotic molecule , FADD-like antiapoptotic molecule 1 , MACH-related inducer of toxicity , caspase homolog , caspase-eight-related protein , caspase-like apoptosis regulatory protein , caspase-related inducer of apoptosis , inhibitor of FLICE , usurpin beta , usurpin , FLICE-like inhibitory protein

373114 Danio rerio
424080 Gallus gallus
459872 Pan troglodytes
574234 Macaca mulatta
779578 Xenopus (Silurana) tropicalis
780745 Xenopus laevis
100142680 Felis catus
100393782 Callithrix jacchus
100474872 Ailuropoda melanoleuca
100589650 Nomascus leucogenys
8837 Homo sapiens
12633 Mus musculus
488471 Canis lupus familiaris
497199 Bos taurus
117279 Rattus norvegicus
100172025 Pongo abelii
414381 Sus scrofa
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