(CASP8 and FADD-Like Apoptosis Regulator (CFLAR))
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Latest Publications for our FLIP products: "Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4." in: Cell reports, Vol. 21, Issue 12, pp. 3427-3444, (2018) (PubMed).
: "The TRAIL-Induced Cancer Secretome Promotes a Tumor-Supportive Immune Microenvironment via CCR2." in: Molecular cell, Vol. 65, Issue 4, pp. 730-742.e5, (2017) (PubMed).
: "Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening." in: Breast cancer research : BCR, Vol. 16, Issue 2, pp. R41, (2014) (PubMed).
: "RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis." in: Nature, Vol. 513, Issue 7516, pp. 90-4, (2014) (PubMed).
: "Poor antibody validation is a challenge in biomedical research: a case study for detection of c-FLIP." in: Apoptosis : an international journal on programmed cell death, Vol. 18, Issue 10, pp. 1154-62, (2013) (PubMed).
: "Release of an ~55kDa fragment containing the actin-binding domain of ?-spectrin by caspase-8 during FND-induced apoptosis depends on the presence of protein 4.1." in: Archives of biochemistry and biophysics, Vol. 535, Issue 2, pp. 205-13, (2013) (PubMed).
: "Expression of c-FLIP in pulmonary metastases in osteosarcoma patients and human xenografts." in: Pediatric blood & cancer, Vol. 60, Issue 4, pp. 575-9, (2013) (PubMed).
: "Predictive value of Sp1/Sp3/FLIP signature for prostate cancer recurrence." in: PLoS ONE, Vol. 7, Issue 9, pp. e44917, (2012) (PubMed).
: "The novel Akt inhibitor API-1 induces c-FLIP degradation and synergizes with TRAIL to augment apoptosis independent of Akt inhibition." in: Cancer prevention research (Philadelphia, Pa.), Vol. 5, Issue 4, pp. 612-20, (2012) (PubMed).
: "CHOP down-regulates cFLIP(L) expression by promoting ubiquitin/proteasome-mediated cFLIP(L) degradation." in: Journal of cellular biochemistry, Vol. 113, Issue 12, pp. 3692-700, (2012) (PubMed).
Synonyms and alternative names related to FLIPCASP8 and FADD-like apoptosis regulator a (cflara), CASP8 and FADD like apoptosis regulator (CFLAR), CASP8 and FADD like apoptosis regulator (cflar), CASP8 and FADD like apoptosis regulator S homeolog (cflar.S), CASP8 and FADD-like apoptosis regulator (Cflar), 2310024N18Rik, A430105C05Rik, c-FLIP, c-Flip, c-FLIPL, c-FLIPR, c-FLIPS, CASH, Cash, CASP8AP1, Casper, cflar, CFLAR, CLARP, Clarp1, ENSMUSG00000072980, FLAME, FLAME-1, FLAME1, FLIP, Flip, Gm9845, I-FLICE, MRIT
Protein level used designations for FLIP
- CASP8 and FADD-like apoptosis regulator
- flice/caspase-i inhibitory protein
- cellular FLICE-like inhibitory protein
- CASP8 and FADD-like apoptosis regulator-like
- FADD-like anti-apoptotic molecule
- FADD-like antiapoptotic molecule 1
- MACH-related inducer of toxicity
- caspase homolog
- caspase-eight-related protein
- caspase-like apoptosis regulatory protein
- caspase-related inducer of apoptosis
- inhibitor of FLICE
- usurpin beta
- FLICE-like inhibitory protein
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