Browse our Clusterin Proteins (CLU)

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Clusterin Proteins (CLU)
On are 65 Clusterin (CLU) Proteins from 12 different suppliers available. Additionally we are shipping Clusterin Antibodies (405) and Clusterin Kits (111) and many more products for this protein. A total of 593 Clusterin products are currently listed.
40, AI893575, APO-J, ApoJ, Cli, CLU, CLU1, CLU2, D14Ucla3, DAG, GP80, gpIII, KUB1, LOC100136120, MGC53055, MGC89163, NA1/NA2, RATTRPM2B, Sgp-2, Sgp2, SP-40, SP40, Sugp-2, TRPM-2, Trpm2, TRPM2B, Trpmb, xclu, zgc:73352
list all proteins Gene Name GeneID UniProt
CLU 1191 P10909
CLU 24854 P05371
CLU 12759 Q06890

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Clusterin Proteins (CLU) by Origin

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Top referenced Clusterin Proteins

  1. Human Clusterin Protein expressed in HEK-293 Cells - ABIN2180885 : Jones, Jomary: Clusterin. in The international journal of biochemistry & cell biology 2002 (PubMed)
    Show all 6 references for 2180885

  2. Mouse (Murine) Clusterin Protein expressed in Human Cells - ABIN2007876 : Silkensen, Schwochau, Rosenberg: The role of clusterin in tissue injury. in Biochemistry and cell biology = Biochimie et biologie cellulaire 1995 (PubMed)
    Show all 2 references for 2007876

  3. Human Clusterin Protein expressed in Human Cells - ABIN2004195 : Djeu, Wei: Clusterin and chemoresistance. in Advances in cancer research 2009 (PubMed)
    Show all 2 references for 2004195

  4. Human Clusterin Protein expressed in Escherichia coli (E. coli) - ABIN1344142 : Shim, Kang, Jeon, Park, Lee, Lee, Park, Lee, Schedin, Min: Clusterin induces matrix metalloproteinase-9 expression via ERK1/2 and PI3K/Akt/NF-?B pathways in monocytes/macrophages. in Journal of leukocyte biology 2011 (PubMed)

More Proteins for Clusterin Interaction Partners

Zebrafish Clusterin (CLU) interaction partners

  1. Zebrafish clusterin is expressed in the notochord and nervous system during development. Clusterin has also role in neuronal cell death and thus, more generally, in neurodegeneration.

  2. Data show that inhibition or targeted knockdown of Notch (show NOTCH1 Proteins) signaling significantly increased clusterin mRNA expression in choroid plexus.

Human Clusterin (CLU) interaction partners

  1. Study demonstrate high concentrations of clusterin (CLU) in mucus samples and significantly reduced CLU levels in cases with endometriosis receiving contraception compared to cases with endometriosis without contraception.

  2. Risk-reducing clusterin genotypes protect against the consequences of poor vascular health on executive function performance and change in older adults without dementia.

  3. Addition of the minor allele for rs670139 (MS4A4E), rs9331896 (CLU), and rs12155159 (NME8 (show TXNDC3 Proteins)) was nominally associated with change on the DWRT, DSST, and WFT, respectively, in whites. For rs670139 and rs9331896 the association was only significant in individuals bearing at least one APOE (show APOE Proteins) 4 allele in stratified analyses.

  4. CLU expression is related to the cellular type and inversely correlated with the presence of lymph node metastases in medullary thyroid carcinoma.

  5. Melittin is capable of suppressing tumor growth and promoting gemcitabine sensitivity in pancreatic ductal adenocarcinomas by downregulating cholesterol pathway gene CLU.

  6. Data show that ELOVL7, SOCS3 (show SOCS3 Proteins), ACSL4 (show ACSL4 Proteins) and CLU were upregulated while PRKAR1A (show PRKAR1A Proteins) and ABCG1 (show ABCG1 Proteins) were downregulated in the phlegm-dampness group.

  7. Both CLU and PLXNA4 (show PLXNA4 Proteins) have been genetically associated with Alzheimer disease (AD) risk and our data thus provide a direct relationship between two AD risk genes. Our data suggest that increasing the levels of PLXNA4 (show PLXNA4 Proteins) or targeting CLU-PLXNA4 (show PLXNA4 Proteins) interactions may have therapeutic value in AD.

  8. Although further studies are required to determine how clusterin suppresses non-specific cellular uptake in phagocytes, our data suggest that clusterin plays a key role in the stealth effect of not only pegylated nanoparticles but also non-pegylated nanoparticles.

  9. the initial rapid aggregation of LDL(-) is apparently counterbalanced by the stabilizing effects of minor proteins such as apoA-I (show APOA1 Proteins) and apoJ. These results help identify key determinants for LDL aggregation, fusion and coalescence into lipid droplets in vivo.

  10. The rs9331888 "GG" genotype in patients and the "CC" genotype in controls were significantly higher in non-4 allele carriers of APOE (show APOE Proteins) The haplotype analysis showed the CLU "GCG (show GCG Proteins)" haplotype was a risk haplotype.

Mouse (Murine) Clusterin (CLU) interaction partners

  1. Both CLU and PLXNA4 (show PLXNA4 Proteins) have been genetically associated with Alzheimer disease (AD) risk and our data thus provide a direct relationship between two AD risk genes. Our data suggest that increasing the levels of PLXNA4 (show PLXNA4 Proteins) or targeting CLU-PLXNA4 (show PLXNA4 Proteins) interactions may have therapeutic value in AD.

  2. clusterin-induced TNF-alpha (show TNF Proteins) and MMP-9 (show MMP9 Proteins) up-regulation is most likely mediated via TLR4 (show TLR4 Proteins) recruitment into lipid rafts; clusterin has a role as an endogenous regulator for TLR4 (show TLR4 Proteins) signaling

  3. susceptibility to experimental pancreatitis is determined by strain and model differences with Clusterin and Pycr1 (show PYCR1 Proteins) alterations

  4. the antioxidant property of clusterin is suggested to regulate the expression of CCL20 (show CCL20 Proteins) in bronchial epithelial cells and the subsequent recruitment of inflammatory dendritic cells in the airway.

  5. these data suggest that activation of prosurvival autophagy by hypoxia in kidney cells requires CLU expression and may be a key cytoprotective mechanism of CLU in the protection of the kidney from hypoxia/ischemia-mediated injury.

  6. Taken together, our results suggest that an NCE-box within the clusterin promoter is necessary for insulin (show INS Proteins)-stimulated hepatic expression of clusterin via SREBP-1c (show SREBF1 Proteins).

  7. Overexpression of clusterin in proximal tubular epithelial cells decreased the levels of Ang II (show AGT Proteins)-stimulated fibrotic markers and AT1R (show AGTRAP Proteins).

  8. Clusterin facilitates stress-induced lipidation of LC3 (show MAP1LC3A Proteins) and autophagosome biogenesis to enhance cancer cell survival.

  9. Results suggest that regulation of clusterin expression by the lymphotoxin beta (show LTB Proteins) signaling pathway and its protein dynamics during immune response suggest a specific role of in the immune system.

  10. we have identified hypothalamic clusterin as a novel anorexigenic molecule that can potentiate central leptin (show LEP Proteins) activity.

Pig (Porcine) Clusterin (CLU) interaction partners

  1. Data demonstrate that the resistance of neonatal porcine Sertoli cells to human xenoantibody and complement-mediated lysis is associated with low expression of xenoantigen alpha-Gal and high production of the complement inhibitors clusterin and CD59 (show CD59 Proteins).

  2. These results show that clusterin expression in porcine species is found in an own, as yet unidentified cell type during postnatal developmental stages.

  3. Porcine spermatozoa may delivery CLU, PRM1 (show PRM1 Proteins) and PRM2 (show PRM2 Proteins) mRNAs to the oocyte, which may contribute to zygotic and early embryonic development.

Cow (Bovine) Clusterin (CLU) interaction partners

  1. The expression of CLU gene was significantly higher among motility-impaired crossbred bull semen compared to the good quality one.

  2. Clusterin haplotype AA may be a genetic marker on mastitis and other performance for Chinese Holstein cows.

Horse (Equine) Clusterin (CLU) interaction partners

  1. The secretion of the potential zonal marker clusterin by zonal articular chondrocytes in osteoarthritic and healthy articular cartilage, was characterized.

Clusterin (CLU) Protein Profile

Protein Summary

The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Alternate splicing results in both coding and non-coding variants.

Alternative names and synonyms associated with Clusterin (CLU)

  • clusterin-1 (LOC100136120)
  • clusterin (clu)
  • clusterin (CLU)
  • Clusterin (clus)
  • clusterin (Clu)
  • 40 protein
  • AI893575 protein
  • APO-J protein
  • ApoJ protein
  • Cli protein
  • CLU protein
  • CLU1 protein
  • CLU2 protein
  • D14Ucla3 protein
  • DAG protein
  • GP80 protein
  • gpIII protein
  • KUB1 protein
  • LOC100136120 protein
  • MGC53055 protein
  • MGC89163 protein
  • NA1/NA2 protein
  • RATTRPM2B protein
  • Sgp-2 protein
  • Sgp2 protein
  • SP-40 protein
  • SP40 protein
  • Sugp-2 protein
  • TRPM-2 protein
  • Trpm2 protein
  • TRPM2B protein
  • Trpmb protein
  • xclu protein
  • zgc:73352 protein

Protein level used designations for Clusterin Proteins (CLU)

clusterin-1 , clusterin , clusterin (complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J) , Clusterin , aging-associated protein 4 , apolipoprotein J , complement cytolysis inhibitor , complement lysis inhibitor , complement-associated protein SP-40,40 , ku70-binding protein 1 , sulfated glycoprotein 2 , testosterone-repressed prostate message 2 , dimeric acid glycoprotein , testosterone repressed prostate message 2 , testosterone-repressed prostate message , testostrone-repressed prostate message 2 , Apolipoprotein J , apo-J , clustrin , testosterone repressed prostate message , testosterone repressed prostate message-2 , glycoprotein 80 , apolipoprotein J/clusterin , CLI , CP40 , glycoprotein III , apolipoprotein J) , Sulfated glycoprotein 2

100136120 Oncorhynchus mykiss
380468 Xenopus laevis
393775 Danio rerio
448332 Xenopus (Silurana) tropicalis
464075 Pan troglodytes
677866 Macaca mulatta
100380352 Salmo salar
1191 Homo sapiens
24854 Rattus norvegicus
12759 Mus musculus
442971 Canis lupus familiaris
100008713 Oryctolagus cuniculus
100734772 Cavia porcellus
397025 Sus scrofa
280750 Bos taurus
100034172 Equus caballus
101113728 Ovis aries
395722 Gallus gallus
101836902 Mesocricetus auratus
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