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Human Clusterin Protein expressed in Escherichia coli (E. coli) - ABIN1344142
Shim, Kang, Jeon, Park, Lee, Lee, Park, Lee, Schedin, Min: Clusterin induces matrix metalloproteinase-9 expression via ERK1/2 and PI3K/Akt/NF-?B pathways in monocytes/macrophages. in Journal of leukocyte biology 2011
Zebrafish clusterin is expressed in the notochord and nervous system during development. Clusterin has also role in neuronal cell death and thus, more generally, in neurodegeneration.
Data show that inhibition or targeted knockdown of Notch (show NOTCH1 Proteins) signaling significantly increased clusterin mRNA expression in choroid plexus.
The results identify Clusterin as a new molecular partner involved in apoptotic cell efferocytosis and suggest a protective role for Clusterin in inflammation and autoimmune diseases.
CLU as novel and promising biomarker for prognosis in patients with chronic HF
FRET and co-IP assays demonstrated that Clu interacted with beta-amyloid peptide (show APP Proteins), a pathological protein of AD, which suggested a potential effect of SelR (show SEPX1 Proteins) and Abeta (show APP Proteins) with the aid of Clu. The interaction between SelR (show SEPX1 Proteins) and Clu provides a novel avenue for further study on the mechanism of SelR (show SEPX1 Proteins) in AD prevention.
The findings of this study provided further evidence for the CLU risk variant as a candidate gene for Alzheimer disease and may serve as a pre-clinical neuroimaging phenotype of late-onset Alzheimer disease.
Study demonstrate high concentrations of clusterin (CLU) in mucus samples and significantly reduced CLU levels in cases with endometriosis receiving contraception compared to cases with endometriosis without contraception.
Risk-reducing clusterin genotypes protect against the consequences of poor vascular health on executive function performance and change in older adults without dementia.
Addition of the minor allele for rs670139 (MS4A4E), rs9331896 (CLU), and rs12155159 (NME8 (show TXNDC3 Proteins)) was nominally associated with change on the DWRT, DSST, and WFT, respectively, in whites. For rs670139 and rs9331896 the association was only significant in individuals bearing at least one APOE (show APOE Proteins) 4 allele in stratified analyses.
CLU expression is related to the cellular type and inversely correlated with the presence of lymph node metastases in medullary thyroid carcinoma.
Melittin is capable of suppressing tumor growth and promoting gemcitabine sensitivity in pancreatic ductal adenocarcinomas by downregulating cholesterol pathway gene CLU.
Data show that ELOVL7, SOCS3 (show SOCS3 Proteins), ACSL4 (show ACSL4 Proteins) and CLU were upregulated while PRKAR1A (show PRKAR1A Proteins) and ABCG1 (show ABCG1 Proteins) were downregulated in the phlegm-dampness group.
Clusterin deficiency worsens renal inflammation and tissue fibrosis after ischemia-reperfusion injury in the kidney.
Both CLU and PLXNA4 (show PLXNA4 Proteins) have been genetically associated with Alzheimer disease (AD) risk and our data thus provide a direct relationship between two AD risk genes. Our data suggest that increasing the levels of PLXNA4 (show PLXNA4 Proteins) or targeting CLU-PLXNA4 (show PLXNA4 Proteins) interactions may have therapeutic value in AD.
clusterin-induced TNF-alpha (show TNF Proteins) and MMP-9 (show MMP9 Proteins) up-regulation is most likely mediated via TLR4 (show TLR4 Proteins) recruitment into lipid rafts; clusterin has a role as an endogenous regulator for TLR4 (show TLR4 Proteins) signaling
susceptibility to experimental pancreatitis is determined by strain and model differences with Clusterin and Pycr1 (show PYCR1 Proteins) alterations
the antioxidant property of clusterin is suggested to regulate the expression of CCL20 (show CCL20 Proteins) in bronchial epithelial cells and the subsequent recruitment of inflammatory dendritic cells in the airway.
these data suggest that activation of prosurvival autophagy by hypoxia in kidney cells requires CLU expression and may be a key cytoprotective mechanism of CLU in the protection of the kidney from hypoxia/ischemia-mediated injury.
Taken together, our results suggest that an NCE-box within the clusterin promoter is necessary for insulin (show INS Proteins)-stimulated hepatic expression of clusterin via SREBP-1c (show SREBF1 Proteins).
Overexpression of clusterin in proximal tubular epithelial cells decreased the levels of Ang II (show AGT Proteins)-stimulated fibrotic markers and AT1R (show AGTRAP Proteins).
Clusterin facilitates stress-induced lipidation of LC3 (show MAP1LC3A Proteins) and autophagosome biogenesis to enhance cancer cell survival.
Data demonstrate that the resistance of neonatal porcine Sertoli cells to human xenoantibody and complement-mediated lysis is associated with low expression of xenoantigen alpha-Gal and high production of the complement inhibitors clusterin and CD59 (show CD59 Proteins).
These results show that clusterin expression in porcine species is found in an own, as yet unidentified cell type during postnatal developmental stages.
Porcine spermatozoa may delivery CLU, PRM1 (show PRM1 Proteins) and PRM2 (show PRM2 Proteins) mRNAs to the oocyte, which may contribute to zygotic and early embryonic development.
The expression of CLU gene was significantly higher among motility-impaired crossbred bull semen compared to the good quality one.
Clusterin haplotype AA may be a genetic marker on mastitis and other performance for Chinese Holstein cows.
The secretion of the potential zonal marker clusterin by zonal articular chondrocytes in osteoarthritic and healthy articular cartilage, was characterized.
The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Alternate splicing results in both coding and non-coding variants.
, clusterin (complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J)
, aging-associated protein 4
, apolipoprotein J
, complement cytolysis inhibitor
, complement lysis inhibitor
, complement-associated protein SP-40,40
, ku70-binding protein 1
, sulfated glycoprotein 2
, testosterone-repressed prostate message 2
, dimeric acid glycoprotein
, testosterone repressed prostate message 2
, testosterone-repressed prostate message
, testostrone-repressed prostate message 2
, Apolipoprotein J
, testosterone repressed prostate message
, testosterone repressed prostate message-2
, glycoprotein 80
, apolipoprotein J/clusterin
, glycoprotein III
, apolipoprotein J)
, Sulfated glycoprotein 2